Hepatobiliary Scintigraphy

Tülchinsky, Mark

doi:10.1007/3-540-30005-8_9

Diagnostic Nuclear Medicine

2006

DOI: 10.1007/3-540-30005-8_9

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Hepatobiliary Scintigraphy

Mark Tülchinsky¹

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Cited by 2 publications

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“…Since the beginning of the COVID-19 global pandemic, many US nuclear medicine physicians and technologists have collectively written 4 petitions to the FDA, emphasizing the safety advantages of 99m Tc-CNP during the pandemic times 6,7 . Liquid aerosols were well known to facilitate the spread of the virus.…”

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Ventilation Scintigraphy With Radiolabeled Carbon Nanoparticulate Aerosol (Technegas)

et al. 2022

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Invented and first approved for clinical use in Australia 36 years ago, Technegas is the technology that enabled ventilation scintigraphy with 99m Tc-labeled carbon nanoparticles ( 99m Tc-CNP). The US Food and Drug Administration (FDA) has considered this technology for more than 30 years but only now is getting close to approving it. Meanwhile, more than 4.4 million patients benefited from this technology in 64 countries worldwide. The primary application of 99m Tc-CNP ventilation imaging is the diagnostic evaluation for suspicion of pulmonary embolism using ventilation-perfusion quotient (V/Q) imaging. Because of 99m Tc-CNP's long pulmonary residence, tomographic imaging emerged as the preferred V/Q methodology. The FDA-approved ventilation imaging agents are primarily suitable for planar imaging, which is less sensitive. After the FDA approval of Technegas, the US practice will likely shift to tomographic V/Q. The 99m Tc-CNP use is of particular interest in the COVID-19 pandemic because it offers an option of a dry radioaerosol that takes approximately only 3 to 5 tidal breaths, allowing the shortest exposure to and contact with possibly infected patients. Indeed, countries where 99m Tc-CNP was approved for clinical use continued using it throughout the COVID-19 pandemic without known negative viral transmission consequences. Conversely, the ventilation imaging was halted in most US facilities from the beginning of the pandemic. This review is intended to familiarize the US clinical nuclear medicine community with the basic science of 99m Tc-CNP ventilation imaging and its clinical applications, including common artifacts and interpretation criteria for tomographic V/Q imaging for pulmonary embolism.

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Ventilation Scintigraphy With Radiolabeled Carbon Nanoparticulate Aerosol (Technegas)

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O’Connor¹,

Maher²

2012

American Journal of Roentgenology

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Hepatobiliary Scintigraphy

Cited by 2 publications

References 118 publications

Ventilation Scintigraphy With Radiolabeled Carbon Nanoparticulate Aerosol (Technegas)

Ventilation Scintigraphy With Radiolabeled Carbon Nanoparticulate Aerosol (Technegas)

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