Hepatoblastoma: current understanding, recent advances, and controversies

Czauderna, Piotr; Garnier, Hanna

doi:10.12688/f1000research.12239.1

Cited by 65 publications

(61 citation statements)

References 32 publications

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“…Many controversies about the treatment of hepatoblastoma still remain. Neoadjuvant chemotherapy combined with surgical treatment is the standard treatment method for hepatoblastoma, and surgical treatment is the basis of comprehensive treatment (12). However, studies have found that the volume of hepatoblastoma will decrease after neoadjuvant chemotherapy, but the distance between the tumor and the main blood vessels has not been significantly reduced (13).…”

Section: Discussionmentioning

confidence: 99%

Clinical and Pathological Study of Tumor Border Invasion—Is Narrow Resection Margin Acceptable in Hepatoblastoma Surgery?

Shen

Zhao

et al. 2020

Front. Med.

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Aim: We aim to study clinically and pathologically whether narrow resection margin (<1 cm) is acceptable in hepatoblastoma surgery.Methods: A total of 42 patients who underwent surgery for hepatoblastoma were selected, and these patients were divided into two groups according to whether or not they underwent preoperative chemotherapy (CHT). The general characteristics of the patients were summarized, the resection margin distance was recorded, and the event-free survival rates were followed up. Pathologically, H&E staining and immunochemical staining were used to study the invasion distance outside the tumor capsule in the tumor border.Results: Clinically, the event-free survival rates were not significantly different between the patients with wide resection margin (>1 cm) and narrow resection margin (<1 cm) of the two groups. Pathologically, the tumor of all 42 patients had capsules surrounding the tumor. Of the patients in Group 1 (without preoperative CHT), 9% (2/22) had micrometastatic cancer nests outside the capsule, and the farthest distance from the cancer nests to the capsule was 4.6 mm. Of the patients in Group 2 (with preoperative CHT), 75% (15/20) showed residual cancer nests in the paratumor liver tissue, and the farthest distance was 9.6 mm; three and two cases, respectively, showed extracapsular intravascular microtumorous thrombi.Conclusion: Clinically and pathologically, narrow resection margin is acceptable in hepatoblastoma surgery.

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Section: Discussionmentioning

confidence: 99%

Clinical and Pathological Study of Tumor Border Invasion—Is Narrow Resection Margin Acceptable in Hepatoblastoma Surgery?

Shen

Zhao

et al. 2020

Front. Med.

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“…At the moment, there is no consensus on the need of post–liver transplant chemotherapy for HB. There are some published studies with good results regardless of the use of post‐transplant chemotherapy . Also, some other centers recommend the use of post‐transplant chemotherapy to prevent tumor recurrence and improve the survival rate…”

Section: Discussionmentioning

confidence: 99%

“…There are some published studies with good results regardless of the use of post-transplant chemotherapy. 23,24 Also, some other centers recommend the use of posttransplant chemotherapy to prevent tumor recurrence and improve the survival rate. 25 We believe it is reasonable to express some concerns on the systematic use of post-transplant chemotherapy in every HB patients, even if they show a clear and sustained descent in post-transplant AFP levels.…”

Section: Discussionmentioning

confidence: 99%

Prognostic factors for event‐free survival in liver transplantation for hepatoblastoma: A single‐center experience

Lauferman

Halac

Aredes

et al. 2019

Pediatric Transplantation

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Hepatoblastoma (HB) is the most common malignant liver tumor in children. Twenty percent of the cases may remain unresectable after neoadjuvant chemotherapy and, for these patients, liver transplant (LT) is an accepted therapeutic option. To analyze the risk factors to event‐free survival (EFS) that influence the clinical outcome of patients with HB receiving LT, we retrospectively analyzed 21 patients with HB who underwent LT between January 1, 2005, and May 1, 2018. Overall survival (OS) was 90%. The univariate analysis shows that the AFP level at the time of LT was associated with a higher risk of EFS. With a ROC curve analysis, we established a cutoff point value of AFP levels at 16 000 ng/dL, with a sensitivity of 71.43% and a specificity of 85.71%. Multivariate analysis showed that patients with higher values of pretransplant AFP (>16 000 ng/dL) had a significantly higher risk of EFS than those transplanted with lower levels (HR: 10.180; 95% CI: 1.54‐66.97; P = .02). Efforts should be made to improve the selection of candidates for LT for unresectable HB, aiming at a better definition of chemoresistance as a risk factor of poor outcomes.

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“…In the liver, the Wnt pathway is essential for homeostasis, embryogenesis, development, maturation, and regeneration [9]. It is also associated with several pathological conditions such as cirrhosis [10], hepatoblastoma [11,12], and hepatocellular carcinoma (HCC) [13]. Currently, several Wnt molecules with potential pharmacological value are being explored for future therapeutic interventions [14,15].…”

Section: Manuscript To Be Reviewedmentioning

confidence: 99%

Peer Review #2 of "Wnt signaling in liver disease: emerging trends from a bibliometric perspective (v0.2)"

2019

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Background: The Wnt signaling pathway, an evolutionarily conserved molecular transduction cascade, has been identified to play a pivotal role in various physiological and pathological processes of the liver, including homeostasis, regeneration, cirrhosis, and hepatocellular carcinoma. In this study, we aimed to use a bibliometric method to evaluate the emerging trends on Wnt signaling in liver diseases. Methods: Articles were retrieved from the Web of Science Core Collection (WoSCC). We used a bibliometric software, CiteSpace V 5.3.R4, to analyze the active countries or institutions in the research field, the landmark manuscripts, important subtopics, and evolution of scientific ideas. Results: In total, 1,768 manuscripts were published, and each was cited 33.12 times on average. The U.S. published most of the manuscripts, and the most active center was the University of Pittsburgh. The top 5 landmark papers were identified by four bibliometric indexes including citation, burstness, centrality, and usage 2013. The clustering process divided the whole area into 9 research subtopics, and the two major important subtopics were "liver zonation" and "hepatocellular carcinoma". Using the "Partof-Speech" technique, 1,743 terms representing scientific ideas were identified. After 2008, the bursting phrases were "liver development" , "progenitor cells," "hepatic stellate cells", "liver regeneration", "liver fibrosis", "epithelial-mesenchymal transition" and etc. Conclusion: Using bibliometric methods, we quantitatively summarized the advancements and emerging trends in Wnt signaling in liver diseases. These bibliometric findings may pioneer the future direction of this field in the next few years, and further studies are needed.

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Hepatoblastoma: current understanding, recent advances, and controversies

Cited by 65 publications

References 32 publications

Clinical and Pathological Study of Tumor Border Invasion—Is Narrow Resection Margin Acceptable in Hepatoblastoma Surgery?

Clinical and Pathological Study of Tumor Border Invasion—Is Narrow Resection Margin Acceptable in Hepatoblastoma Surgery?

Prognostic factors for event‐free survival in liver transplantation for hepatoblastoma: A single‐center experience

Peer Review #2 of "Wnt signaling in liver disease: emerging trends from a bibliometric perspective (v0.2)"

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