Hepatocellular adenoma among adult survivors of childhood and young adult cancer

Abstract

Hepatocellular adenoma (HCA) is a rare benign epithelial neoplasm with potential for hemorrhage, rupture, or malignant transformation. Reported annual incidence of HCA is approximately 1/1,000,000. We identified twelve cases of HCA among adults with a history of childhood or young adult cancer. The most common cancer diagnosis was leukemia (N=4). Five had undergone allogeneic hematopoietic stem cell transplant with total body irradiation. All eleven females had prior estrogen therapy; the male case was hypogonadal. This report suggests childhood and young adult cancer survivors may be at increased risk for HCA, but further investigation is needed.

Incidence of and Risk Factors for Histologically Confirmed Solid Benign Tumors Among Long-term Survivors of Childhood Cancer

“…Other site-specific analyses [13][14][15] were hampered by small numbers of cases; several known radiosensitive tissues were represented (eg, salivary, thyroid, and parathyroid glands). In line with a recent US report among 1296 CCSs (6 cases [0.5%]), 28 we identified 4 (0.1%) liver adenomas.…”

Human hepatocellular adenoma as a promising cell source for bioartificial liver systems

“…HCA is a rare monoclonal benign liver tumor, which originates in the epithelium and usually develops within a healthy liver (18). HCA is more prevalent in females than in males and the use of oral contraceptives and anabolic steroids are established risk factors for the disease (19).…”

Pediatric Hepatocellular Adenomas: What Is Known and What Is New?

“…Glycogen storage diseases, in particular types I and III, have been shown to have a younger incidence of HCAs, multifocal tumors, and a higher risk of rupture compared to adenomas in the general pediatric population [15]. Among the acquired conditions, pediatric HCAs have been reported with the Fontan procedure [16], secondary to androgen therapy prior to hematopoietic stem cell transplantation [17], as a late complication of prior cancer therapy [18], and as a potential complication of oxcarbazepine therapy for seizure disorder [19]. All age groups are affected in children, including rare cases of prenatally detected tumors [20].…”