Hepatocellular carcinoma and fetal hemoglobin.

Mori, Wataru

doi:10.2739/kurumemedj.26.205

Cited by 1 publication

(1 citation statement)

References 14 publications

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“…Patients with inherited bone marrow failure syndromes (Diamond-Blackfan anemia, dyskeratosis congenita, Fanconi anemia, Shwachman-Diamond syndrome) often have increased HbF as part of their 'stressed' hematopoiesis that also includes macrocytosis and erythropoietin levels higher than predicted by their degree of anemia [10]. Rarely, increased HbF levels have been observed in solid tumors including choriocarcinoma, adenocarcinoma of the lung and hepatoma [11][12][13][14].…”

Section: Discussionmentioning

confidence: 99%

Blessing in disguise; a case of Hereditary Persistence of Fetal Hemoglobin

Shaukat

Pudal

Yassin

et al. 2018

Journal of Community Hospital Internal Medicine Perspectives

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Fetal Hemoglobin (HbF, α2γ2) is produced from the eighth week of gestation, constitutes 60 – 80 % of total hemoglobin by birth, which is then replaced with adult Hemoglobin A1 (HbA1: α2β2) by 6–12 months. Hereditary Persistence of Fetal Hemoglobin (HPFH) is a rare benign asymptomatic genetic disorder where the HbF persists, and incidentally discovered on screening for other hemoglobinopathies. In adults, the variation in HbF levels could also be associated with other disease states, including hemoglobinopathies, leukemias and bone marrow failure syndromes. Here we present a case of a young asymptomatic female with the incidental finding of HPFH who was misdiagnosed as the sickle cell disease. It is important to have awareness about HPFH and should be distinguished from other causes of elevated HbF.

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Section: Discussionmentioning

confidence: 99%