Hepatocellular Carcinoma and Hepatitis C Virus

Wang, Shenghan; Yeh, Shiou–Hwei; Chen, Pei‐Jer

doi:10.1007/978-4-431-56101-9_4

Cited by 3 publications

(4 citation statements)

References 182 publications

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“…28 44 Marital status was also noted to be a significant predictor of NPC survival, with married individuals having a lower mortality risk in comparison to single individuals with NPC, which matched previously reported studies on the topic. 24 Expectedly, women were found to have greater survival odds than male patients which validates earlier studies that found that female sex was protective against mortality risk due to biological factors rather than behavioral sex disparities. 45 46…”

Section: Discussionsupporting

confidence: 83%

“…34 Specific to NPC, there has been one study that examined the influence of insurance coverage on NPC survival rate, focusing on marital status in relation to insurance coverage and survival rate and finding that having both insurance and a spouse results in a significantly better 5-year NPC survival rate. 24 The current analysis expands on the literature by focusing specifically on health insurance status, while controlling for possible confounders, in various stages of NPC.…”

Section: Discussionmentioning

confidence: 99%

“…21 22 23 In addition, one study examined marital status in relation to insurance type and survivability of NPC, but did not analyze tumor stage as a factor in survivability in relation to insurance. 24 This study seeks to assess the association between health insurance coverage and survival outcomes while also examining specific factors such as cancer stage that may affect prognosis within a U.S. population diagnosed with NPC using the Surveillance, Epidemiology, and End Results (SEER) program database (2007–2016).…”

Section: Introductionmentioning

confidence: 99%

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Health Insurance Coverage and Survival Outcomes among Nasopharyngeal Carcinoma Patients: A SEER Retrospective Analysis

Diaz

Bujnowski

Chen

et al. 2022

J Neurol Surg B Skull Base

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Objectives Insurance coverage plays a critical role in head and neck cancer care. This retrospective study examines how insurance coverage affects nasopharyngeal carcinoma (NPC) survival in the United States using the Surveillance, Epidemiology, and End Results (SEER) program database. Design, Setting, and Participants A total of 2,278 patients aged 20 to 64 years according to the International Classification of Diseases for Oncology (ICD-O) codes C11.0–C11.9 and ICD-O histology codes 8070–8078 and 8080–8083 between 2007 and 2016 were included and grouped into privately insured, Medicaid, and uninsured groups. Log-rank test and multivariable Cox's proportional hazard model were performed. Main Outcome Measures Tumor stage, age, sex, race, marital status, disease stage, year of diagnosis, median household county income, and disease-specific survival outcomes including cause of death were analyzed. Results Across all tumor stages, privately insured patients had a 59.0% lower mortality risk than uninsured patients (hazard ratio [HR]: 0.410, 95% confidence interval [CI]: [0.320, 0.526], p < 0.01). Medicaid patients were also estimated to have 19.0% lower mortality than uninsured patients (HR: 0.810, 95% CI: [0.626, 1.048], p = 0.108). Privately insured patients with regional and distant NPC had significantly better survival outcomes compared with uninsured individuals. Localized tumors did not show any association between survival and type of insurance coverage. Conclusion Privately insured individuals had significantly better survival outcomes than uninsured or Medicaid patients, a trend that was preserved after accounting for tumor grade, demographic and clinicopathologic factors. These results underscore the difference in survival outcomes when comparing privately insured to Medicaid/uninsured populations and warrant further investigation in efforts for health care reform.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Health Insurance Coverage and Survival Outcomes among Nasopharyngeal Carcinoma Patients: A SEER Retrospective Analysis

Diaz

Bujnowski

Chen

et al. 2022

J Neurol Surg B Skull Base

View full text Add to dashboard Cite

show abstract

“…Hepatitis C virus (HCV), a hepatotropic RNA virus with a prevalence of about 3% worldwide, causes serious liver damage, including liver fibrosis, liver cirrhosis and hepatocellular carcinoma. 1 Generally, HCV is divided into six major genotypes (types 1–6), and the JFH-1 strain of HCV belongs to genotype 2a and is the first HCV strain that can produce HCV particles in Huh7 cells. 2 At present, the main factors of HCV infection are the unsterile medical procedures and unsafe injection drugs used in countries with high HCV prevalence.…”

Section: Introductionmentioning

confidence: 99%