Hepatocellular carcinoma and liver tumors in South African children

Moore, Samuel W.; Millar, A. J. W.; Hadley, G. P.; Ionescu, Gabriel; Kruger, Mariana; Poole, Janet; Stones, David; Wainwright, Linda; Chitnis, Milind; Wessels, G.

doi:10.1002/cncr.20398

Cited by 51 publications

(48 citation statements)

References 60 publications

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“…HCC is one of the most common malignant tumors in China, however, the etiological factors of HCC in China differ from those in the developed countries (Moore et al, 2004). HCC in China is commonly associated with hepatitis B (Zhiqiang et al, 2004), and a large proportion of the HCC patients in China are commonly accompanied by other chronic liver diseases (Cao et al, 2009;Jiang et al, 2009;Lam and Poon, 2008).…”

Section: Discussionmentioning

confidence: 99%

Expression of apolipoprotein M in human hepatocellular carcinoma tissues

Jiang

Luo

et al. 2011

Acta Histochemica

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SummaryThe present study examined mRNA levels and protein mass of apolipoprotein M (apoM) in human hepatocellular carcinoma (HCC) tissues and in its adjacent tissues. Plasma apoM levels in these HCC patients were also determined and compared to the normal subjects. The mean level of plasma apoM in the HCC patients was 0.61±0.30 OD*mm -2 , which was significantly higher than that in the normal subjects 0.37±0.07 OD*mm -2 (P<0.01). However, both apoM mRNA levels and apoM protein mass in the HCC tissues were significantly lower than in its adjacent tissues (P<0.05). It is concluded that human hepatocellular carcinoma tissues had less capacity to produce apoM than the adjacent non-tumor tissues. However, the plasma apoM levels were higher in the HCC patients than in normal subjects, which suggested that tumor-adjacent tissues or extra-hepatic apoM production in the HCC patients may contribute to the higher plasma apoM levels in these patients. The clinical significance of apoM in relation to HCC needs further investigation.

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Section: Discussionmentioning

confidence: 99%

Expression of apolipoprotein M in human hepatocellular carcinoma tissues

Jiang

Luo

et al. 2011

Acta Histochemica

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“…Criteria of surgical resection for patients with HCC were 1 patients with tumor involving no more than 3 Healey's segments, 2 Child-Turcotte-Pugh (CTP) class A with less than 25% retention of indocyanine green 15 minutes after injection, and 3 no main portal vein trunk involvement or distant metastasis. Liver transplantation was considered in patients fulfilling the Milan criteria with coexisting CTP class B or C cirrhosis.…”

Section: Treatmentmentioning

confidence: 99%

Selecting an optimal staging system for hepatocellular carcinoma

Hsu

Hsia

Huang

et al. 2010

Cancer

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BACKGROUND: Selecting an appropriate staging system is crucial to predict the outcome of patients with hepatocellular carcinoma (HCC). The optimal prognostic model for HCC is under intense debate. This study investigated the prognostic ability of the 5 currently used staging systems, Barcelona Clinic Liver Cancer (BCLC), Cancer of the Liver Italian Program (CLIP), Japan Integrated Scoring (JIS) system, tumor-node-metastasis (TNM), and Tokyo score, for HCC. METHODS: Between 2002 and 2008, 1713 prospectively enrolled HCC patients were compared for their longterm survival by using the Akaike information criterion (AIC) according to the staging or scoring methods of these 5 models. RESULTS: The mean and median follow-up duration was 18 and 14 months, respectively. Among all patients, the CLIP staging system had the lowest AIC value in comparison with other systems in the Cox proportional hazards model, followed by the Tokyo score, JIS score, BCLC staging system, and TNM staging system. Patients undergoing curative treatment had a significantly better survival in comparison with patients undergoing noncurative treatment (P < .001). When the predictive accuracy of the staging systems was analyzed according to treatment strategy, the CLIP staging system had the lowest AIC value and remained the best prognostic model in patients undergoing curative (801 patients) and noncurative (912 patients) treatment. CONCLUSIONS: The CLIP staging system is the best long-term prognostic model for HCC in a cohort of patient with early to advanced stage of HCC. Its predictive accuracy is independent of the treatment strategy. Selecting an optimal staging system is helpful in improving the design of future clinical trials.

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“…Sarcomas are the third most common malignant primary hepatic tumors, comprising approximately 6% of hepatic malignancies in childhood [18]. For example, Moore et al [8] reported 194 cases of malignant primary hepatic tumors in children. Of these patients, 58% had HB, 35% had HCC, and 5% had sarcomas of the liver (including 6 poorly differentiated sarcomas, 2 rhabdomyosarcomas, 1 angiosarcoma, and 1 mesenchymal carcinoma).…”

Section: Discussionmentioning

confidence: 99%