Hepatocellular carcinoma: Defining the place of surgery in an era of organ shortage

Bartlett, Adam; Heaton, Nigel

doi:10.3748/wjg.14.4445

Cited by 17 publications

(6 citation statements)

References 71 publications

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“…For many years liver transplantation and partial hepatectomy have been considered as the main forms of curative treatment. 35 Liver transplantation is theoretically the best option for HCC, as it permits both radical resection of the primary tumor and treatment of the underlying liver disease, with 70 per cent 5-year survival and a recurrence rate below 15 per cent. 17,[36][37][38] OLT, however, is unavailable worldwide and the shortage of liver donors induces a steadily increasing waiting time that sharply deteriorates the results of OLT when analyzed according to intention to treat.…”

Section: Discussionmentioning

confidence: 99%

Does Surgical Resection Have a Role in the Treatment of Large or Multinodular Hepatocellular Carcinoma?

Ramacciato

Mercantini

Petrucciani

et al. 2010

The American Surgeon™

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Several effective treatments are available for patients with small solitary hepatocellular carcinomas (HCCs). Conversely, the management of patients with large or multinodular HCCs is controversial, and the role of surgical resection is not well defined. Between 2000 and 2006, 51 patients with large or multinodular HCC underwent liver resection. Clinicopathologic and follow-up data were prospectively collected and retrospectively reviewed. The perioperative and long-term outcomes were analyzed. Univariate and multivariate analysis of prognostic factors were conducted. Although 20 patients had multinodular HCCs, 31 had large solitary tumors. Perioperative mortality occurred in eight patients and complications in 15. In patients with large solitary tumors, 5-year disease-free and overall survival were 41.3 per cent and 56.1 per cent, respectively. Those with multinodular HCCs demonstrated 5-year disease-free and overall survival rates of 0 per cent and 33.6 per cent, respectively. Liver resection can result in long-term survival in select patients with large or multinodular HCCs, even in select patients with impaired liver function. Large solitary HCCs seem to have better prognoses than multinodular tumors, with lower recurrence and higher survival rates after surgery. Randomized controlled trials comparing resection to other treatment modalities are indicated to determine optimal patient management.

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Section: Discussionmentioning

confidence: 99%

Does Surgical Resection Have a Role in the Treatment of Large or Multinodular Hepatocellular Carcinoma?

Ramacciato

Mercantini

Petrucciani

et al. 2010

The American Surgeon™

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“…Surgery is the only cure for HCC. The decision to resect or transplant is often determined by the experience of the transplantation centre and by the availability of donor organs (11).…”

Section: Liver Tumoursmentioning

confidence: 99%

What is New in Liver Surgery?

Höckerstedt

2011

Scand J Surg

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“…Hepatocellular carcinoma (HCC) is the most common primary liver cancer in the world and its incidence is steadily increasing [1,2] Surgical resection is the most appropriate treatment for patients with resectable HCC and good hepatic reserve function [3]. Liver transplantation, conversely, is offered to patients with unresectable HCC or tumors associated with more advanced liver cirrhosis [2].…”

Section: Introductionmentioning

confidence: 99%

Expansion of the criteria for living donor liver transplantation for hepatocellular carcinoma

Lee

Suh

2016

Current Opinion in Organ Transplantation

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Hepatocellular carcinoma: Defining the place of surgery in an era of organ shortage

Cited by 17 publications

References 71 publications

Does Surgical Resection Have a Role in the Treatment of Large or Multinodular Hepatocellular Carcinoma?

Does Surgical Resection Have a Role in the Treatment of Large or Multinodular Hepatocellular Carcinoma?

What is New in Liver Surgery?

Expansion of the criteria for living donor liver transplantation for hepatocellular carcinoma

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