Hepatocellular carcinoma (HCC) in non-cirrhotic liver: clinical, radiological and pathological findings

Martino, Michele Di; Saba, Luca; Bosco, Sandro; Rossi, Massimo; Miles, Kirchin; Miscio, Rossella Di; Lombardo, Concetta Valentina; Tamponi, E; Piga, M.; Catalano, Carlo

doi:10.1007/s00330-014-3173-2

Cited by 50 publications

(48 citation statements)

References 34 publications

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“…Di Martino et al [44] demonstrated that noninvasive diagnostic criteria of HCC are present in 90% of cases and that the HCC in non-cirrhotic patients shows a similar pattern of enhancement as HCC in cirrhotic patients. Based on these results it would be reasonable to apply non-invasive diagnostic criteria for HCC in non-cirrhotic patients if they have high levels of α-fetoprotein.…”

Section: [35]mentioning

confidence: 99%

Radiological diagnosis of hepatocellular carcinoma in non-cirrhotic patients

Castan¹,

Navarro²,

Sarría³

et al. 2017

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Section: [35]mentioning

confidence: 99%

Radiological diagnosis of hepatocellular carcinoma in non-cirrhotic patients

Castan¹,

Navarro²,

Sarría³

et al. 2017

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“…However, the noncirrhotic study groups were composed of patients with liver fibrosis of different degrees with single or multiple tumors, and a wide range of clinical manifestations. Moreover, most reports about HCC on noncirrhotic liver have described surgical and/or pathologic findings,with few studies on clinical and imaging findings …”

Section: Introductionmentioning

confidence: 99%

“…Moreover, most reports about HCC on noncirrhotic liver have described surgical and/or pathologic findings, 5,7 with few studies on clinical and imaging findings. [10][11][12] Ultrasonography (US) is now the most important diagnostic tool for the liver, and contrast-enhanced US (CEUS) currently allows detailed observation of liver tumors. 13,14 The purpose of the present study was to retrospectively evaluate the clinical, pathological, and US findings of HCC developed in normal liver.…”

Section: Introductionmentioning

confidence: 99%

Hepatocellular carcinoma in otherwise sonographically normal liver

Naganuma¹,

Ishida

Ogawa

et al. 2018

J of Clinical Ultrasound

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Purpose Hepatocellular carcinoma (HCC) on normal liver is very rare. The goal of this study was to determine the clinical manifestations and the role of ultrasonography (US) in the diagnosis of HCC arising in normal liver. Methods The clinical data and US findings in 12 cases of surgically resected HCC in normal liver were retrospectively analyzed. Results The patients were asymptomatic, had no hepatocarcinogenic factor, and hepatic function tests were almost normal in most cases. HCCs were large, encapsulated, and solitary, and there were predominantly well‐differentiated or moderately differentiated in most cases. US showed a hypoechoic rim and lateral shadowing, suggestive of peritumoral capsule formation, and on contrast‐enhanced US (CEUS), the tumor was hyperenhanced in arterial phase and washed out in postvascular phase, revealing typical HCC findings. Conclusions US raises suspicion of HCC by showing lateral shadowing on grayscale ultrasound and hypervascularity on CEUS of the lesion.

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“…In patients with cirrhosis, the 5 year cumulative occurrence of HCC is between 5-30% depending on the causes of the disease, and associated cirrhosis is seen in 80-90% of patients with HCC (2,3). Due to the growing population of obesity and other metabolic syndromes, there is an increasing incidence of HCC due to non-alcoholic fatty infiltration liver disease; the incidence of HCC continues to grow in spite of the hepatitis B and C viruses' infection being prevented by the development of vaccines and anti-viral therapies (4,5). The fact that the classic imaging features could yield a definite diagnosis and the probability of needle track seeding are limiting the necessity of liver biopsy (6).…”

Section: Introductionmentioning

confidence: 99%