Hepatocellular Carcinoma in Asia: A Challenging Situation

Jafri, Wasim; Kamran, Muhammad

doi:10.5005/jp-journals-10018-1292

Cited by 34 publications

(26 citation statements)

References 101 publications

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“…Hepatocellular carcinoma (HCC) is the sixth most common cancer globally and the third leading cause of death related to cancer in Asia 1 . Curative treatments are only feasible in the early stages of HCC, however, the limitations of current surveillance methods lead to a high proportion of HCC being detected at late stages 2 .…”

Section: Introductionmentioning

confidence: 99%

Praeruptorin A reduces metastasis of human hepatocellular carcinoma cells by targeting ERK/MMP1 signaling pathway

Yang

et al. 2020

Environmental Toxicology

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Praeruptorin A (PA) is one of the active ingredients found in the dried root of Peucedanum praeruptorum Dunn, has been reported to possess anticancer effects against various types of cancer. However, the effect of PA on human hepatocellular carcinoma (HCC) remains uncleared. In this study, our results indicated that PA did not induce cytotoxicity or alter cell cycle distribution in human HCC cells (Huh‐7, SK‐Hep‐1, and PLC/PRF/5 cells). Instead, PA inhibited the migration and invasion of human HCC cells while downregulating the expression of matrix metalloproteinase‐1 (MMP1) and activating the extracellular signal‐regulated kinase (ERK) signaling pathways. Furthermore, blocking the ERK signaling pathway through siERK restored the expression of MMP1 and the invasive ability of PA‐treated HCC cells. In conclusion, our results demonstrate the antimetastatic activity of PA against human HCC cells, supporting its potential as a therapeutic agent of HCC treatments.

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Section: Introductionmentioning

confidence: 99%

Praeruptorin A reduces metastasis of human hepatocellular carcinoma cells by targeting ERK/MMP1 signaling pathway

Yang

et al. 2020

Environmental Toxicology

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“…A male predominance of HBV-related HCC is prevalent, in common with other regions in the world. As a risk factor for the development of HBV-related HCC, aflatoxin can induce early development of HBV-related HCC in some Asian populations [94] . Another notable finding is the development of progressive liver disease, including HCC, in HBeAg-negative chronic HBV-infected patients.…”

Section: Target Populationmentioning

confidence: 99%

Hepatitis B-related hepatocellular carcinoma: surveillance strategy directed by immune-epidemiology

Anugwom¹,

Allaire²,

Akbar³

et al. 2021

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Hepatitis B infection (HBV) is one of the most common causes of hepatocellular carcinoma (HCC) worldwide. The age of occurrence, prognosis and incidence vary dramatically depending on the region of the world. This geographic variation is largely dependent on the contrasting incidence of HBV, age of transmission of the virus, the timing of integration into the human genome, and different HBV genotypes, as well as environmental factors. It results in a wide difference in viral interaction with the immune system, genomic modulation and the consequent development of HCC in an individual. In this review, we describe many factors implicated in HCC development, provide insight regarding at-risk populations and explain societal recommendations for HCC surveillance in persons living with HBV in different continents of the world.

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“…Intensive work has been conducted to identify HCC risk factors (eg, Hepatitis virus infections, non-alcoholic fatty liver disease and obesity, smoking and alcohol as well as the genetic background) and to implement preventive measurements. 2 At present, despite considerable progress in HCC prevention, diagnosis and intervention, only 20% of the patients survive more than one year after diagnosis. 3 A number of serological biomarkers have been widely used in diagnosis of HCC, [4][5][6] such as alpha-fetoprotein (AFP), alpha-L-fucosidase (AFU), gamma-glutamyl transferase (GGT), des-gamma-carboxy prothrombin (DCP), glypican-3 (GPC3) and golgi glycoprotein 73 (GP73).…”

Section: Introductionmentioning

confidence: 99%

High Expression of LINC01268 is Positively Associated with Hepatocellular Carcinoma Progression via Regulating MAP3K7

Jin

et al. 2021

OTT

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Objective As one of the most common neoplastic diseases, hepatocellular carcinoma (HCC) has a high morbidity and mortality, which seriously threatens human health and places a heavy burden on society and medical care. At present, effective early diagnosis, prognosis and treatment of HCC are limited. Altered gene expression patterns of lncRNA are associated with the occurrence, development and prognosis of various malignancies, including HCC. The aim of this study was to investigate the correlation between the expression of LINC01268 and HCC, and to elucidate the potential underlying molecular mechanism. Methods Expression level and localization of LINC01268 in human liver cancer cells and HCC tissues were investigated using RT-qPCR and fluorescent in situ hybridization (FISH), respectively. Correlation of expression levels of LINC01268 and MAP3K7 with differentiation and poor overall patient survival of HCC were analyzed using in house collected and publicly available HCC tissue data. RT-qPCR and Western blot were applied to inspect the effects of depletion and overexpression of LINC01268 on MAP3K7 expression. HCC cell proliferation and apoptosis were also investigated by simultaneous overexpression of LINC01268 and knockdown of MAP3K7, in order to delineate that MAP3K7 is a downstream effector of LINC01268. Results In this study, we identified that LINC01268 was highly expressed in HCC cell lines and tissues. High LINC01268 expression level was associated with lower HCC nodule number, moderate/poor differentiation and poor overall survival. Knockdown of LINC01268 inhibited the proliferation of HCC cells, which was enhanced by overexpression of LINC01268. Co-expression analysis implied an interaction between LINC01268 and MAP3K7. Similar to LINC01268, MAP3K7 was highly expressed in HCC cells, and positively correlated with moderate/poor differentiation as well as poor prognosis. Knockdown of LINC01268 in HCC cell lines led to reduction of MAP3K7 at both mRNA and protein levels. Phenotypic effects due to LINC01268 overexpression in HCC cells were reversed by knockdown of MAP3K7. Conclusion Taken together, the abnormal high expression of LINC01268 is associated with HCC progression via regulating MAP3K7, suggesting LINC01268 as a novel marker for HCC prognosis and potentially a new therapeutic target.

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Hepatocellular Carcinoma in Asia: A Challenging Situation

Cited by 34 publications

References 101 publications

Praeruptorin A reduces metastasis of human hepatocellular carcinoma cells by targeting ERK/MMP1 signaling pathway

Praeruptorin A reduces metastasis of human hepatocellular carcinoma cells by targeting ERK/MMP1 signaling pathway

Hepatitis B-related hepatocellular carcinoma: surveillance strategy directed by immune-epidemiology

High Expression of LINC01268 is Positively Associated with Hepatocellular Carcinoma Progression via Regulating MAP3K7

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