Hepatocellular Carcinoma in Children with Hepatitis B Surface Antigen.

Tazawa, Yusaku; Nishinomiya, Fujihiko; Noguchi, Hiroo; Tsuchiya, Shigeru; Hayashi, Yutaka; Abukawa, Daiki; Watabe, M.; Nakagawa, Michiko; Imaizumi, Masue; Ohi, Ryoji; Tada, Keiya; Konno, Tasuke

doi:10.1620/tjem.167.47

Cited by 7 publications

(3 citation statements)

References 23 publications

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“…Because the number of cases with HCC in our study was limited, we performed an evaluation of the literature to survey for previously published cases with HBV-related HCC with accompanying AFP measurements at diagnosis. As a result, a total of 26 pediatric cases (historical patients) were collected from 11 reports [14][15][16][17][18][19][20][21][22][23][24]. The combined data of the 26 historical patients and the 14 present patients were utilized to assess the sensitivity of AFP as a diagnostic test of HCC.…”

Section: Evaluation Of the Sensitivity Of Afp In The Diagnosis Of Hbvmentioning

confidence: 99%

Hepatocellular carcinoma in children and young patients with chronic HBV infection and the usefulness of alpha‐fetoprotein assessment

et al. 2016

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The aims of the study were to elucidate the clinical characteristics of patients who developed hepatocellular carcinoma (HCC) related to persistent HBV infection since childhood and to investigate usefulness of assessing alpha‐fetoprotein (AFP) in this population. A nationwide multicenter survey of children with chronic HBV infection was performed. Among 548 patients, 15 patients developed HCC at the median age of 15 years (range 9–36), including 13 males and 2 females. A case–control comparison showed that HBeAg seroconversion and liver cirrhosis were associated with the occurrence of HCC. Of the 15 HCC patients, 5 were treated with interferon and none of them responded to interferon therapy as compared with 12 of the 17 responders in the control group. Of the 15 patients, 10 died and 9 of the 10 who died never visited any medical facilities until diagnosis of HCC, while the remaining 5 surviving patients never stopped their clinic visits. The usefulness of AFP assessment was shown by the findings that AFP levels were elevated in all HCC cases, that elevations in AFP levels were detected prior to the diagnosis in the surviving patients, and that sensitivity of AFP as a diagnostic test for HCC was very high among 40 patients including our 14 and an additional 26 collected from the literature. HBeAg seroconversion and liver cirrhosis are associated with the occurrence of HCC. Regular measurement of AFP might be helpful to watch for the occurrence of HCC when following children and young patients with chronic HBV infection since childhood

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Section: Evaluation Of the Sensitivity Of Afp In The Diagnosis Of Hbvmentioning

confidence: 99%

Hepatocellular carcinoma in children and young patients with chronic HBV infection and the usefulness of alpha‐fetoprotein assessment

et al. 2016

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“…Hepatoblastoma develops in infants and young children, mostly under the age of 2 years (9,10), but it is seldom associated with cirrhosis and multicentric lesions (9)(10)(11). Hepatocellular carcinoma rarely develops in children (9)(10)(11)(12) and is often associated with cirrhosis from various diseases including biliary atresia, neonatal hepatitis syndrome, posthepatitic cirrhosis, and metabolic diseases including tyrosinemia type I (12)(13)(14)(15)(16)(17). Liver cirrhosis, a common complication of tyrosinemia type I, is followed by hepatocellular carcinoma after 4 years of age in the chronic form of the disease (16).…”

Section: Discussionmentioning

confidence: 99%

An Acute Form of Tyrosinemia Type I With Multiple Intrahepatic Mass Lesions

Tazawa,

Kikuchi,

Kurobane

et al. 1990

J. pediatr. gastroenterol. nutr.

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SummaryThe acute form of tyrosinemia type I usually causes severe hepatocellular dysfunction. We report a 4‐month‐old infant with hepatosplenomegaly, ascites, and multiple intrahepatic mass lesions mimicking hepatoma. A marked increase of serum α‐fetoprotein (97.6 μg/ml) and multiple small low‐density lesions in the liver demonstrated by computed tomography suggested the presence of hepatoma. The liver specimens obtained at laparatomy showed mixed nodular cirrhosis with fatty metamorphosis. Serum levels of tyrosine (6.6 mg/100ml) and methionine (5.9 mg/100 ml) were increased. Urinary organic acid analyses disclosed increased excretions of succinylacetone (1,330 mg/g creatinine) and δ‐amino‐levulinic acid (113.6 mg/g creatinine). Histological abnormalities and biochemical evidences led to the correct diagnosis. This case emphasizes the need for complete investigations of puzzling cases and warns against undue reliance on noninvasive imaging techniques.

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“…Histological examination of nontumor tissue confirmed cirrhosis in six of eight cases. Tazawa and colleagues (22) described four cases of childhood HCC from Japan; HBsAg was documented for 3-11 years before diagnosis of the tumor, and all were associated with cirrhosis in the nontumorous liver.…”

Section: Natural History and Complicationsmentioning

confidence: 99%