Hepatocellular carcinoma in non-cirrhotic versus cirrhotic liver: a clinico-radiological comparative analysis

Jamwal, Rupie; Krishnan, Venkatram; Kushwaha, Dinesh Singh; Khurana, Rajat

doi:10.1007/s00261-020-02561-z

Cited by 18 publications

(13 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present study showed that the majority of HCC nodules arose in the right lobe (72.7%%) with a ratio of predisposition for right-left lobe involvement of almost 3:1, a result that is consistent with that found in the literature (57-68%) [18,33,34]. Moreover, a particularly interesting result was that only 2.8% of the nodules were in the caudate lobe.…”

Section: Discussionsupporting

confidence: 92%

Segmental Distribution of Hepatocellular Carcinoma in Cirrhotic Livers

et al. 2022

View full text Add to dashboard Cite

Background: To evaluate the segmental distribution of hepatocellular carcinoma (HCC) according to Couinaud’s anatomical division in cirrhotic patients. Methods: Between 2020 and 2021, a total of 322 HCC nodules were diagnosed in 217 cirrhotic patients who underwent computed tomography (CT) or magnetic resonance imaging (MRI) for the evaluation of suspicious nodules (>1 cm) detected during ultrasound surveillance. For each patient, the segmental position of the HCC nodule was recorded according to Couinaud’s description. The clinical data and nodule characteristics were collected. Results: A total of 234 (72.7%) HCC nodules were situated in the right lobe whereas 79 (24.5%) were detected in the left lobe (p < 0.0001) and only 9 nodules were in the caudate lobe (2.8%). HCC was most common in segment 8 (n = 88, 27.4%) and least common in segment 1 (n = 9, 2.8%). No significant differences were found in the frequencies of segmental or lobar involvement considering patient demographic and clinical characteristics, nodule dimension, or disease appearance. Conclusions: The intrahepatic distribution of HCC differs among Couinaud’s segments, with segment 8 being the most common location and segment 1 being the least common. The segmental distribution of tumour location was similar to the normal liver volume distribution, supporting a possible correlation between HCC location and the volume of hepatic segments and/or the volumetric distribution of the portal blood flow.

show abstract

Section: Discussionsupporting

confidence: 92%

Segmental Distribution of Hepatocellular Carcinoma in Cirrhotic Livers

et al. 2022

View full text Add to dashboard Cite

show abstract

Section: Diagnosismentioning

confidence: 99%

“…Few studies evaluated clinico-radiological characteristics in NCHCC and found that they differ compared to CHCC[ 86 ]. Time of contrast washout correlates with histopathological grade in HCC[ 86 ]. US is rarely used for diagnosis of the NCHCC due to its non-specific findings, especially for tumors which are less than 2 cm in size, obesity and background of cirrhosis[ 87 ].…”

Section: Diagnosismentioning

confidence: 99%

“…Patients with NCHCC can present with large tumor size lesions, solitary mass (with or without satellite lesions)[ 90 ]. They can have well-defined margins with mosaic pattern of enhancement, complete capsule and delayed washout on the CT[ 86 ]. This in comparison to CHCC which showed smaller lesions, ill-defined margins, heterogeneous enhancement, no capsule and portal venous phase washout (Table 2 ).…”

Section: Diagnosismentioning

confidence: 99%

See 1 more Smart Citation

Non-cirrhotic hepatocellular carcinoma in chronic viral hepatitis: Current insights and advancements

Perisetti

Goyal

Thandassery

et al. 2021

WJG

View full text Add to dashboard Cite

Primary liver cancers carry significant morbidity and mortality. Hepatocellular carcinoma (HCC) develops within the hepatic parenchyma and is the most common malignancy originating from the liver. Although 80% of HCCs develop within background cirrhosis, 20% may arise in a non-cirrhotic milieu and are referred to non-cirrhotic-HCC (NCHCC). NCHCC is often diagnosed late due to lack of surveillance. In addition, the rising prevalence of non-alcoholic fatty liver disease and diabetes mellitus have increased the risk of developing HCC on non-cirrhotic patients. Viral infections such as chronic Hepatitis B and less often chronic hepatitis C with advance fibrosis are associated with NCHCC. NCHCC individuals may have Hepatitis B core antibodies and occult HBV infection, signifying the role of Hepatitis B infection in NCHCC. Given the effectiveness of current antiviral therapies, surgical techniques and locoregional treatment options, nowadays such patients have more options and potential for cure. However, these lesions need early identification with diagnostic models and multiple surveillance strategies to improve overall outcomes. Better understanding of the NCHCC risk factors, tumorigenesis, diagnostic tools and treatment options are critical to improving prognosis and overall outcomes on these patients. In this review, we aim to discuss NCHCC epidemiology, risk factors, and pathogenesis, and elaborate on NCHCC diagnosis and treatment strategies.

show abstract

“…To the editor, I read with interest the article titled "Hepatocellular carcinoma in non-cirrhotic versus cirrhotic liver: a clinico-radiological comparative analysis" published in this issue [1]. The authors have reported interesting and relevant results.…”

mentioning

confidence: 99%

Differences in the characteristics of hepatocellular carcinoma between cirrhotic and non-cirrhotic livers

Gupta

2020

Abdom Radiol

View full text Add to dashboard Cite

Hepatocellular carcinoma in non-cirrhotic versus cirrhotic liver: a clinico-radiological comparative analysis

Cited by 18 publications

References 35 publications

Segmental Distribution of Hepatocellular Carcinoma in Cirrhotic Livers

Segmental Distribution of Hepatocellular Carcinoma in Cirrhotic Livers

Non-cirrhotic hepatocellular carcinoma in chronic viral hepatitis: Current insights and advancements

Differences in the characteristics of hepatocellular carcinoma between cirrhotic and non-cirrhotic livers

Contact Info

Product

Resources

About