Hepatocellular carcinoma metastasis to the lacrimal gland: A case report

Chen, Hua; Li, Jinpeng; Wang, Lijun; Cong, Ning; Shi, Congcong; Song, Jukun; Bu, Wenzhe

doi:10.3892/ol.2014.2191

Cited by 11 publications

(4 citation statements)

References 10 publications

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“…Its distant metastases are rare; however, bony metastases were noted in one patient [ 5 ]. There is only one case in the literature of a solitary lacrimal gland tumor from metastatic HCC [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

Retinal and vitreous metastases from hepatocholangiocarcinoma

et al. 2017

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BackgroundTo report a case of metastatic hepatocholangiocarcinoma to the vitreous and retina.Case presentationA 70-year-old male, who was recently diagnosed with hepatocholangiocarcinoma, was complaining of floaters in his right eye over the past 5 months and was referred to the Liverpool Ocular Oncology Centre. On presentation, his visual acuity in the right eye was 6/24. Fundus exam revealed a whitish, unilateral, full-thickness retinal lesion at the inferotemporal arcade of his right eye, with vitreous infiltration and subretinal fluid. The patient underwent 25G pars plana vitrectomy with biopsy, resection of the lesion and intravitreal bevacizumab injection. Histopathology testing of the surgical specimens confirmed the diagnosis of metastatic carcinoma to the eye. Two months postoperatively his visual acuity had improved to 6/7.5 and there was no sign of active disease in his right eye, while 9 months postoperatively his visual acuity decreased to 6/9.5 due to developing nuclear sclerotic cataract in his right eye.ConclusionThe current report presents the first case of a hepatocholangiocarcinoma metastasis to the vitreous and retina.

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Section: Discussionmentioning

confidence: 99%

Retinal and vitreous metastases from hepatocholangiocarcinoma

et al. 2017

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“…Orbital metastases in the lacrimal sac region, while very rare, have previously been described as arising from hepatocellular carcinoma and renal cell carcinoma primaries 16,17 . Orbital metastases originating from other primary cancers-including breast, prostate, lung, skin, parotid, colon, kidney, thyroid, and neuroblastoma-have been described [18][19][20] .…”

Section: Discussionmentioning

confidence: 99%

Orbital Mass as First Presentation of Metastatic p16-Positive Oropharyngeal Squamous Cell Carcinoma

et al. 2017

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We describe a case in which a 67-year-old man was diagnosed with a metastatic recurrence of p16-positive oropharyngeal squamous cell carcinoma after presenting with a medial orbital mass in the region of the nasolacrimal apparatus. A review of the literature revealed that metastasis to the orbit from any malignancy is an uncommon occurrence, and no cases of p16-positive oropharyngeal squamous cell carcinoma have previously been reported. Our case highlights the importance of maintaining a high index of suspicion during surveillance visits with such patients.

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“…To the authors' knowledge, only 24 cases have been described. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] Herein, the authors review lacrimal gland metastatic disease and describe the first known case from a primary anorectal SCC. In this patient with human immunodeficiency virus, an HPV-driven tumor hematogenously spread to the lacrimal gland in the form of diffuse intravascular tumor deposits that did not erupt in the lacrimal parenchyma to create a discrete mass lesion.…”

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confidence: 99%

Lacrimal Gland Intravascular Micrometastasis From a Human Papillomavirus-Driven Anorectal Squamous Cell Carcinoma With a Review of Metastatic Disease to the Lacrimal Gland

Neerukonda

Freitag

Stagner

et al. 2020

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Purpose: To document a unique case of anorectal squamous cell carcinoma that was metastatic to the microvasculature of the lacrimal gland in a patient with human immunodeficiency virus and to review previously reported cases of metastases to the lacrimal gland. Methods: Both a retrospective chart review and comprehensive literature review were performed. The unusual histopathologic pattern of the current case was illustrated with immunohistochemical studies (CD31, D2-40, pancytokeratin, p16, and p63) and in situ hybridization studies for high-risk human papillomavirus types 16 and 18. Results: The authors describe the first case of metastatic anorectal squamous cell carcinoma to the lacrimal gland. Only 24 cases of metastatic disease to the lacrimal gland have been reported, the majority from breast carcinomas. The metastasis did not form a macroscopic lesions, instead was composed of microscopic intravascular and intraparenchymal tumor deposits, a subtle phenomena. Immunohistochemistry confirmed the presence of the intravascular neoplastic cells. p16 served as a surrogate marker for human papillomavirus-associated squamous cell carcinoma and was confirmed with in situ hybridization for human papillomavirus 16 and 18. This testing, combined with the clinical history, defined the diagnosis and confirmed human papillomavirus as the tumor driver. Conclusions: Metastases to the lacrimal gland remain rare, but clinicians and pathologists alike must be attuned to the possibility of subtle microscopic foci of tumor as a pattern of metastasis in scenarios without a discrete mass-forming lesion, as this may portend a poor prognosis.

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Hepatocellular carcinoma metastasis to the lacrimal gland: A case report

Cited by 11 publications

References 10 publications

Retinal and vitreous metastases from hepatocholangiocarcinoma

Retinal and vitreous metastases from hepatocholangiocarcinoma

Orbital Mass as First Presentation of Metastatic p16-Positive Oropharyngeal Squamous Cell Carcinoma

Lacrimal Gland Intravascular Micrometastasis From a Human Papillomavirus-Driven Anorectal Squamous Cell Carcinoma With a Review of Metastatic Disease to the Lacrimal Gland

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