2022
DOI: 10.1016/j.biomaterials.2022.121527
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Hepatocellular carcinoma organoid co-cultures mimic angiocrine crosstalk to generate inflammatory tumor microenvironment

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Cited by 44 publications
(32 citation statements)
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“…In addition, co-culture of cells of a specific type within TME with tumor organoids can also help partially characterize TME. This has been successful in some tumor organoids (53,55,56).…”
Section: The Disadvantage and Perspective Of Hcc Organoids For Target...mentioning
confidence: 99%
“…In addition, co-culture of cells of a specific type within TME with tumor organoids can also help partially characterize TME. This has been successful in some tumor organoids (53,55,56).…”
Section: The Disadvantage and Perspective Of Hcc Organoids For Target...mentioning
confidence: 99%
“…Further, MCTS models comprising cancer cells and HUVEC or other endothelial cells can better reveal possible antiangiogenic activity, which increases metastasis compared to in vitro monolayer cultures. It was shown that 3D co-cultures of patient-derived xenograft organoids or HCC cells with endothelial cells increase the expression of CXCL16, IL-8, and MCP-1, indicating effective HCC cell-endothelial cells interactions in the 3D model (36). Interactions in the in vitro coculture of peripheral blood mononuclear cells (PBMCs) with HCC cells and non-HCC hepatocytes increase antigen presentation by HCC hepatocytes and activate PBMCs, leading to apoptosis of activated CD8+ T cells.…”
Section: Challenges In Using Model Systems To Recapitulate Liver Diseasementioning
confidence: 99%
“…While tumour organoids have offered insight into how TAMs may act as friend or foe, caution must be taken when optimising the culture conditions (especially the external growth factor/cytokine supply), as they might shift the phenotypes of many cell types and mask the true effect of tumour–immune interaction. Future organoid-based TAM research may detail how TAMs cause T cell dysfunction [ 99 ], tumour cell inflammation, metabolic derangements [ 100 ], and increased angiogenesis [ 101 , 102 ] (discussed below). In fact, an M1–M2 dichotomy may be an oversimplification for TAMs in vivo, which can possess markers for both M1 and M2 at the same time [ 103 ].…”
Section: Translational Immuno-oncology Research With Organoidsmentioning
confidence: 99%