Hepatocellular carcinoma presenting as a huge intra-abdominal mass: A case report

Abstract

Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver and is generally associated with hepatitis B or C virus-related cirrhosis. A giant intra-abdominal HCC mass that fills nearly the whole abdomen is not often reported in the literature. In this report, we present a case in which a patient with hepatitis B developed a giant intra-abdominal mass that originated from segment three of the liver and infiltrated the stomach and transverse colon. We were able to resect the tumor without leaving any tumor tissue behind. Although HCC presenting as a huge mass with invasion of the gastrointestinal tract is uncommon, this pathology should be considered in the differential diagnosis of giant intra-abdominal masses. The case presented here also indicates that surgical resection is possible in selected patients.

Hepatocellular Carcinoma with Gastrointestinal Involvement: A Systematic Review

“…Sites of the lower part of the gastrointestinal tract, such as the colon, jejunum, ileum and rectum were also less affected. In exceptional cases, a liver tumor can simultaneously involve more than one segment of the GI tract [7,51,58,59,65,66,80].…”

Hepatic resection for two giant hepatocellular carcinoma after oral direct-acting antiviral therapy: Is there a relationship?

“…direct-acting antiviral drugs questioned the impact of those drugs on the occurrence or recurrence of HCC in patients with HCV related cirrhosis. [3,[7][8][9] Such finding was not seen in other cases treated with interferon-based regimens, and this endorsed specialists to propose that those drugs may play a significant role in the development of HCC. [3,8,9] On the other hand, other studies have reported the opposite effect of direct-acting antiviral drugs on HCC occurrence or recurrence.…”

“…[3,[7][8][9] Such finding was not seen in other cases treated with interferon-based regimens, and this endorsed specialists to propose that those drugs may play a significant role in the development of HCC. [3,8,9] On the other hand, other studies have reported the opposite effect of direct-acting antiviral drugs on HCC occurrence or recurrence. [10,11] The relationship between direct-acting antiviral agents and HCC occurrence or recurrence and the underlying possible mechanisms remain controversial and there is no enough evidence to prove or disprove this relationship.…”