Hepatocellular carcinoma surveillance in non-alcoholic fatty liver disease patients

Hepatocellular carcinoma surveillance in non-alcoholic fatty liver disease – who and how?

“…It would be more accurate to assess HCC risk directly, rather than extrapolating HCC risk from fibrosis stage. Several genome-wide association studies have identified single nucleotide polymorphisms (SNPs) such as patatin-like phospholipase domain-containing protein 3 (PNPLA3) which could be linked to increased risk of HCC (21). Polygenic risk scores including these SNPs have been found to improve detection of HCC particularly in individuals with dysmetabolism, and was able to predict HCC independently of presence of severe fibrosis in NAFLD patients (22).…”