Hepatocellular carcinoma with indolent T-lymphoblastic proliferation

Exuberant cortical thymocyte proliferation mimicking T-lymphoblastic lymphoma within recurrent large inguinal lymph node masses of localized Castleman disease

“…In addition, these recurrent masses had identical histologic features (major CD and minor T-lymphoblastic components), suggesting that the coexistence of these two components may be related or share some underlying common pathogenic mechanism. (3) Unlike the previous 6 reported cases [7][8][9][10][11], our patient had no concomitant malignant neoplasm, and is alive and well without any radio-or chemotherapy and no recurrence after 5 years.…”

“…In previous reports, small lymphocytes associated with the T lymphoblasts were described in 8 of 12 patients [3,4,[7][8][9][11][12][13], with "an immunophenotypic pattern suggesting thymocyte maturation" [3]. Our case showed small T lymphoblasts histologically and immunophenotypically consistent with the normal intermediate stage of thymocyte differentiation, and mature T lymphocytes were admixed with the T lymphoblasts.…”

“…Moreover, of all 13 reported patients thus far, including ours, the mass was resected in 6 [7][8][9][10]12]. Notably, in 6 of 6 patients with a resected mass, the T-lymphoblastic component was small and occurred as an incidental finding and not causative of the mass [7][8][9][10]12].…”

Follicular dendritic cell sarcoma with immature T-cell proliferation

“…The origin of the immature T cells in nonlymphomatous conditions is obscure [7][8][9][10]. Physiologically, TdT + T cells are only present in the thymus and bone marrow, and CD4 + / CD8 + /TdT + precursor T cells are confined to the thymic cortex.…”

“…Shallow and deep cytoplasmic indentations in the tumor cell nuclei were seen by electron microscopy (inset).TdT + /CD1a + immature T cells and an association with MG. The other 2 cases were of immature T-cell infiltration in hepatocellular carcinoma (Wang et al[7], Shin et al[8]). In addition, 2 unusual examples of masslike nonneoplastic Tlymphoblastic proliferations in the oropharynx have been reported.…”