Hepatocellular carcinoma with ring calcification mimicking hydatid disease: a case report

Matsunaga, Yutaro; Ariizumi, Shun‐ichi; Shibuya, Go; Uemura, Shuichiro; Kato, Takuya; Yazawa, Takehisa; Yamashita, Satoshi; Omori, Akiko; Higuchi, Ryota; Takahashi, Yutaka; Kotera, Yoshihito; Egawa, Hiroto; Yamamoto, Masakazu

doi:10.1186/s40792-020-00927-5

Cited by 4 publications

(4 citation statements)

References 21 publications

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“…Therefore, the relationship and mechanism need to be further explored. During treatment of these diseases, misdiagnosis between hepatic hydatid disease and HCC occurs often, which needs more cautious when diagnosing (16). The patient survived for 5 years after surgery already, we believe that we can do more, but we failed for the patient's own factors.…”

Section: Discussionmentioning

confidence: 93%

Hepatocellular Carcinoma Complicated by Echinococcal Cyst: A Case Report

Guo

Song

et al. 2022

Front. Surg.

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Hepatocellular carcinoma (HCC), combined with hepatic hydatid disease, is a rare clinical case, having certain specificity in clinical diagnosis and treatment. We report a case of HCC combined with hepatic hydatid disease treated in our clinic to arouse the attention of clinicians to the disease. A 54-year-old female patient was admitted to the clinic on October 31, 2016 because of “Intermittent upper abdominal pain and discomfort for 1 month.” Abdominal CT in the previous hospital showed liver space-occupying lesions, and hepatic hydatid disease should be considered. The patient had a history of hepatitis B virus (HBV) infection since childhood but has not received antiviral treatment. She did have a history of life in pastoral areas. Laboratory examination results were as follows: alpha-fetoprotein (AFP) 1,210 ng/ml, HBV DNA: 5.32E + 3 IU/ml. Casoni test was positive. Enhanced CT of abdomen suggestion was: malignant liver tumor, hepatic hydatid disease. Gastroscopy and colonoscopy showed no abnormalities. She underwent an operation on November 10, 2016. Segment 5, 8 of hepatic, echinococcus internal capsule, and cholecyst were all removed. She took albendazole (0.4 g/day) for 6 months and oral entecavir (0.5 mg/day) antiviral treatment for a long time after surgery. From May 2017 to October 2019, a total of 5 cycles of transarterial chemotherapy embolization (TACE) were performed. The patient underwent surgical treatment, followed by TACE, antiviral therapy, and sequential albendazole treatment. The AFP level increased significantly, but there was no obvious recurrence of HCC in imaging.

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Section: Discussionmentioning

confidence: 93%

Hepatocellular Carcinoma Complicated by Echinococcal Cyst: A Case Report

Guo

Song

et al. 2022

Front. Surg.

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“…Calcified granulomas also tend to develop in the lungs. Gallstones develop in the gallbladder, but calcified cysts caused by Echinococcosis usually affect the liver and are also located in the right upper abdominal quadrant (Matsunaga et al, 2020). Most urinary stones form in the kidneys or bladder, but phleboliths usually form in the pelvic veins (Luk et al, 2017), and enteroliths are in the bowel (Salelkar et al, 2011), that is, in a location similar to that in which urinary stones may be found.…”

Section: Discussionmentioning

confidence: 99%

SEM technology for the analysis of tiny calcified remains from a pre‐Hispanic burial from El Hierro (Canary Islands)

Ordóñez,

Suárez‐Toste,

Cockerill

et al. 2023

Archaeometry

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Scanning Electron Microscopy (SEM) coupled with energy‐dispersive X‐ray spectroscopy (EDX) enables the determination of the composition and structure of tiny calcified remains occasionally recovered during burial excavations. To deepen the practical application of this technique, we performed SEM/EDX analysis on three different tiny mineralized, roughly rounded structures with a diameter of less than 5 mm, recovered from a pre‐Hispanic collective funerary cave from El Hierro (Canary Islands) and a mineral spherulite of similar size and outer aspect. After SEM imaging and spectroscopic analysis, we conclude that the three samples represent a sesamoid bone, a kidney stone, and a possible case of sialolithiasis. In contrast, the spherulite is a mineral formation composed of calcium carbonate. Our data confirm SEM analysis's usefulness in identifying small, mineralized remains recovered during burial excavations and its contribution to studying past populations. However, we are aware that taphonomic changes may alter, at least partially, the structure and/or elemental composition of archaeological samples, obscuring differential diagnosis.

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“…As the detection of calcifications is difficult in a MRI examination, an additional CT examination is recommended in all problematic cases. Although HCC may rarely be partly calcified, the distribution and morphology of the calcification, especially if they are seen in thick necrotic debris, should indicate a degenerated, inactive form of CE [ 19 ]. The difficulties in a preoperative diagnosis in patients with concomitant HCC and CE were also pointed out in previous studies.…”

Section: Discussionmentioning

confidence: 99%

Hepatocellular Carcinoma Presenting Simultaneously with Echinococcal Cyst Mimicking a Single Liver Lesion in a Non-Cirrhotic Patient: A Case Report and Review of the Literature

et al. 2022

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A coexistance of liver cystic echinococcosis (CE) and hepatocellular carcinoma (HCC) is very rare. HCC is the leading cause of cancer-related mortality worldwide, while CE is a globally endemic zoonosis caused by the cestode tapeworm Echinococcus granulosus. The association between these two diseases is still not well-defined. A preoperative diagnosis may be challenging, especially if HCC and CE present as a single lesion and if atypical imaging features are present. Herein, we present a case of the patient that was initially diagnosed as an extensive necrotic tumor in the left liver lobe and highly suspicious of being HCC associated with peritumoral hematoma. Left hemihepatectomy was performed, and the histopathological findings showed the collision of two lesions: a hydatid cyst and HCC.

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Hepatocellular carcinoma with ring calcification mimicking hydatid disease: a case report

Cited by 4 publications

References 21 publications

Hepatocellular Carcinoma Complicated by Echinococcal Cyst: A Case Report

Hepatocellular Carcinoma Complicated by Echinococcal Cyst: A Case Report

SEM technology for the analysis of tiny calcified remains from a pre‐Hispanic burial from El Hierro (Canary Islands)

Hepatocellular Carcinoma Presenting Simultaneously with Echinococcal Cyst Mimicking a Single Liver Lesion in a Non-Cirrhotic Patient: A Case Report and Review of the Literature

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