Hepatocellular carcinoma with situs inversus totalis and polysplenia syndrome

Li, Tao; Wang, Lu; Chen, Rongxin; Ye, Qing–Hai; Sun, Hui‐Chuan; Qin, Lun–Xiu; Tang, Zhao–You

doi:10.1111/j.1478-3231.2007.01597.x

Cited by 9 publications

(10 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most of the patients were having normal sr. bilirubin and other liver function tests at the time of presentation, except one where very high bilirubin (44.5 nmol/L) [21]. The diagnostic serum marker for HCC, AFP was higher in 9 cases and normal in 4 patients including our patient.…”

Section: Hcc With Sitmentioning

confidence: 43%

“…The patients were aged from 37 to 85 years, which include 9 males and 4 females. The variety of presentations in these patients include asymptomatic [20,21], abdominal pain [10,[22][23][24], abdominal lump [4,10,13,22], cirrhosis with ascites [25], hypoglycaemia with convulsion [4] and azospermia with bronchiectasis [13].…”

Section: Hcc With Sitmentioning

confidence: 99%

“…Conventional or CT angiography was done in all the cases, 7 patients have normal mirror image presentation, but others have anomalous left hepatic vessels [3,10], common hepatic artery [25] and IVC continuous as hemiazygos vein [21].…”

Section: Hcc With Sitmentioning

confidence: 99%

See 2 more Smart Citations

Situs Inversus Totalis (SIT) with Hepatocellular Carcinoma (HCC): A Rare Case Report and Review of 12 Other Cases

et al. 2012

View full text Add to dashboard Cite

Hepatocellular carcinoma (HCC) is the seventhmost common malignancy in males and ninth in females with incidence of one million new cases every year. Situs inversus totalis (SIT) is a rare congenital condition, in which there is a mirror-image transposition of both the abdominal and thoracic viscera. There are very few reported cases of HCC developing in people with SIT. In this review, we present a new case of HCC with SIT, and a review of literatures published between 1983 and 2011 on it. The literatures in English were searched through PubMed and Google Scholar, while those in Japanese language were accessed through J-EAST and translated in English with the help of Google translator on 22 April 2012. There are 6 English and 6 Japanese literatures showing 12 published cases, of which 10 cases were from Japan, 1 from Taiwan and 1 from China. Our case is probably the first case in the world beyond these regions. The articles containing adequate information, such as patient age and sex, investigations, diagnosis, type of congenital anomalies and methods of surgery, were reviewed. On reviewing the literature, we observed that clinical manifestations, laboratory findings and etiology correlate well with HCC, while anomalous hepatic vascularity correlates well with SIT. The reason for high incidence of HCC with SIT in Japan is not well correlated, but may be explained by higher incidence of SIT. All varieties of hepatic resection were feasible in cases of SIT.

show abstract

Section: Hcc With Sitmentioning

confidence: 43%

Section: Hcc With Sitmentioning

confidence: 99%

See 1 more Smart Citation

Situs Inversus Totalis (SIT) with Hepatocellular Carcinoma (HCC): A Rare Case Report and Review of 12 Other Cases

et al. 2012

View full text Add to dashboard Cite

show abstract

“…The coexistence of HCC in a patient with situs ambiguous with pS is exceptional. Our search of the english literature published up to 2012 found only one such case [5] and one suspected case [6] (Table 1). Regarding the suspected case, despite a diagnosis of HCC with situs inversus totalis and polysplenia syndrome, this case may actually be categorized as situs ambiguous with pS because it was associated with azygos vein continuation of the IVC with absence of the retro-hepatic IVC.…”

Section: Discussionmentioning

confidence: 97%

“…To our knowledge, as of 2012, only one other such case [5] and one suspected case [6] had been reported in the english literature. We report the first known case of a patient with situs ambiguous with pS, who underwent anatomical hepatic resection of the reversed liver for HCC.…”

mentioning

confidence: 80%

Hepatic resection for hepatocellular carcinoma in a patient with situs ambiguous with polysplenia: report of a case

et al. 2014

View full text Add to dashboard Cite

We report a case of successful resection of hepatocellular carcinoma (HCC) in a patient with situs ambiguous with polysplenia (PS), a rare congenital anomaly. A 62-year-old Japanese man was admitted to our hospital for investigation and treatment of a hepatic tumor. Imaging studies revealed two HCCs, 2.5 and 0.7 cm in diameter, in the anterior section and segment 3 of the reversed liver, respectively. He also had multiple spleens in the right side of the abdomen, right side of the stomach, and duodenum, as well as azygous continuation of the inferior vena cava (IVC) with absence of the retro-hepatic IVC, a truncated pancreas, rare variation of the hepatic artery, and dextrocardia. We performed anterior sectionectomy of the liver and partial resection of segment 3. We found only two previous reports of HCC in patients with situs ambiguous with PS, but our patient is the first to have undergone anatomical hepatic resection of the reversed liver. Accurate anatomical assessment is essential during surgery on such patients.

show abstract

Polysplenia syndrome: a review of the relationship with viscero-atrial situs and the spectrum of extra-cardiac anomalies

et al. 2013

View full text Add to dashboard Cite

Polysplenia syndrome is classified as one of the situs ambiguous or heterotaxy syndromes and is classically termed left isomerism or bilateral left-sidedness. However, polysplenia is a controversial and complex entity with no fixed pathognomonic features but rather a broad spectrum of abnormalities. In many published case series, polysplenia was neither associated with viscero-atrial heterotaxy nor with duplication of left-sided structures. The relationship between polysplenia and viscero-atrial situs is not clear. Several recent case reports describe the association of polysplenia with situs inversus totalis or with pancreatic; venous and other anomalies or with several types of malignancy. This article provides the reader with a review of the literature as well as our own experience aiming at better understanding of the polysplenia syndrome, its relationship with viscero-atrial situs and the spectrum of associated extra-cardiac anomalies.

show abstract

Hepatocellular carcinoma with situs inversus totalis and polysplenia syndrome

Cited by 9 publications

References 7 publications

Situs Inversus Totalis (SIT) with Hepatocellular Carcinoma (HCC): A Rare Case Report and Review of 12 Other Cases

Situs Inversus Totalis (SIT) with Hepatocellular Carcinoma (HCC): A Rare Case Report and Review of 12 Other Cases

Hepatic resection for hepatocellular carcinoma in a patient with situs ambiguous with polysplenia: report of a case

Polysplenia syndrome: a review of the relationship with viscero-atrial situs and the spectrum of extra-cardiac anomalies

Contact Info

Product

Resources

About