2015
DOI: 10.1016/j.jceh.2015.04.001
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Hepatocellular Carcinoma Without Cirrhosis Presenting With Hypercalcemia: Case Report and Literature Review

Abstract: Background: Hepatocellular carcinoma (HCC) in non-cirrhotic livers is an uncommon finding and can present insidiously in patients. Another uncommon finding in HCC, and one of poor prognosis, is the presence of paraneoplastic diseases such as hypercalcemia. We report a case of a 66-year-old previous healthy Filipina woman who after routine laboratory evaluation was discovered to have hypercalcemia as the first sign of an advanced HCC without underlying cirrhosis. Because of the patient's relative lack of sympto… Show more

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Cited by 13 publications
(11 citation statements)
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“…Other symptoms include abdominal distention, weight loss, malaise, anorexia, fatigue, chronic diarrhea, jaundice, chest pain and fever of unknown origin[4,83,84]. Non-cirrhotic HCC can also present in the form of paraneoplastic syndrome of hypercalcemia or hypoglycemia[82,85]. FLC has been known to present with gynecomastia, recurrent deep vein thrombosis, Budd-Chiari syndrome, non-bacterial thrombotic endocarditis, fulminant liver failure or encephalopathy[10].…”
Section: Clinical Featuresmentioning
confidence: 99%
“…Other symptoms include abdominal distention, weight loss, malaise, anorexia, fatigue, chronic diarrhea, jaundice, chest pain and fever of unknown origin[4,83,84]. Non-cirrhotic HCC can also present in the form of paraneoplastic syndrome of hypercalcemia or hypoglycemia[82,85]. FLC has been known to present with gynecomastia, recurrent deep vein thrombosis, Budd-Chiari syndrome, non-bacterial thrombotic endocarditis, fulminant liver failure or encephalopathy[10].…”
Section: Clinical Featuresmentioning
confidence: 99%
“…Acting through a common PTH/PTH-rP receptor, PTH-rP inhibits calcium excretion from the kidney and promotes bone resorption leading to hypercalcemia [3]. As shown in studies investigating the prevalence and prognosis of different paraneoplastic syndromes in HCC, HHM can be found in 4-8% of HCC [4]. HHM has rarely been reported in patients with cholangiocarcinoma (CC) and represents a marker of poor prognosis of the disease [59].…”
Section: Discussionmentioning
confidence: 99%
“…In primary tumors of the liver, hypercalcemia is a highly uncommon event [1]. It is discussed in 4.5% to 8% of the literature for hepatocellular carcinoma (HCC) [1].…”
Section: Introductionmentioning
confidence: 99%
“…In primary tumors of the liver, hypercalcemia is a highly uncommon event [1]. It is discussed in 4.5% to 8% of the literature for hepatocellular carcinoma (HCC) [1]. Cholangiocellular carcinoma (CCC) is even more rarely reported to be associated with a paraneoplastic syndrome with hypercalcemia and only a few case reports have been published so far [212], mainly in Asian patients [38,10,11] (Table 1).…”
Section: Introductionmentioning
confidence: 99%
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