Hepatocellular enzyme glutathione S‐transferase alpha and intrahepatic cholestasis of pregnancy

Joutsiniemi, Titta; Leino, Riitta; Timonen, Susanna; Pulkki, Kari; Ekblad, Ulla

doi:10.1080/00016340802468316

Cited by 6 publications

(2 citation statements)

References 20 publications

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“…A longitudinal study comparing serum levels from ICP, control and pruritus gravidarum cases demonstrated higher GSTA in ICP at all gestations from 24 wk to term [67] . A recent study confirmed that GSTA levels are elevated in ICP cases [68] , and the authors of both studies proposed that it may be a useful tool for early diagnosis of the condition.…”

Section: Lfts In Icpmentioning

confidence: 86%

Intrahepatic cholestasis of pregnancy

Geenes

Williamson

2009

WJG

545

490

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Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder characterized by maternal pruritus in the third trimester, raised serum bile acids and increased rates of adverse fetal outcomes. The etiology of ICP is complex and not fully understood, but it is likely to result from the cholestatic effects of reproductive hormones and their metabolites in genetically susceptible women. Equally unclear are the mechanisms by which the fetal complications occur. This article reviews the epidemiology, clinical features, diagnosis, etiology and management of ICP.

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Section: Lfts In Icpmentioning

confidence: 86%

Intrahepatic cholestasis of pregnancy

Geenes

Williamson

2009

WJG

545

490

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“…Elevation of plasma level of α-GST may be an early indicator of liver damage. Different studies considered the plasma level of α-GST is an actual indicator of the integrity of the hepatocyte [19] or biomarker of liver damage, for example, in hepatic ischemia/reperfusion injury after liver resection [20], cases of rejection of liver transplant [21], liver damage after hepatectomy [22], biliary atresia [23], intrahepatic cholestasis of pregnancy [24], acute drug-induced hepatotoxicity [25], subclinical hepatic injury after anesthesia [26], hepatocellular damage during polymicrobial sepsis [27], or in patients with cystic fibrosis [28] and in chronic alcohol abusers [29]. …”

Section: Discussionmentioning

confidence: 99%

Significance of Serum Alpha-Glutathione S-Transferase Assessment in Hepatitis C Patients with Different Alanine Aminotransferase Patterns

Abdel-Moneim

Sliem

2011

Gastroenterol Res

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BackgroundAlpha-Glutathione S-transferase (α-GST) is a liver enzyme which showed properties making it useful in assessment of liver cell damage. A number of studies demonstrated its early elevation in different hepatic insults, but its pattern in HCV was controversial. Consequently, we planned this work to study the significance of Serum Alpha-Glutathione S-Transferase (α-GST) assessment in hepatitis C patients with different alanine aminotransferase (ALT) patterns.MethodsSixty-five untreated male patients with history of hepatitis C virus (HCV) positive antibodies and 21 healthy age- and sex-matched control subjects were enrolled in this study. Sera were collected for confirmation of the presence of HCV antibodies (by ELISA) as well as for assessment of the levels of α-GST, ALT, aspartate aminotransferase, alkaline phosphatase, gamma glutamyl-transferase, total proteins, albumin and HCV RNA. HCV RNA was detected by the reverse transcription polymerase chain reaction (RT-PCR). Based on ALT level, patients were divided into three groups. Twelve patients with normal ALT levels (NALT), 29 with near normal ALT levels (NNALT), and 24 with high ALT levels (HALT). All data were statistically analyzed for significance and correlation as well as sensitivity, specificity, positive and negative predictive values.ResultsThe mean value of α-GST in HCV patients was significantly higher compared to the control with 82% sensitivity, 85% specificity, 98% positive predictive value and 63% negative predictive value. These results were more or less similar to the results of ALT and higher than the results of all the other assayed liver function tests. The sensitivity, and positive and negative predictive values of α-GST were lower than aminotransferases, but higher than the other assayed liver function tests in NNALT and HALT groups. Nevertheless, in NALT, these parameters were higher for α-GST than all the other assayed liver function tests including aminotransferases.ConclusionsAssay of α-GST has an adjuvant in evaluation of liver cell damage in HCV patients. However, its role is much more valuable in patients with normal aminotransferases for early detection of liver cell damage.

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