Hepatocyte growth factor (HGF) in patients with acute brucellosis

Özden, Mehmet; Kalkan, Ahmet; Demirdag, Kutbettin; Kılıç, Süleyman; Denk, Affan; Yuce, Pinar

doi:10.1080/00365540410019110

Cited by 5 publications

(6 citation statements)

References 12 publications

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“…That may be explained by Guillén et al 25 who showed that hepatocyte synthesis of CRP is independent from HGF during acute-phase reactions. However, this was contrary to many studies which found a significant positive correlation between them in many infections e.g in pneumonia including being a therapeutic predictor 12 , in acute Brucellosis in which both of them were significantly correlated and significantly declined after treatment 26 .…”

Section: Discussioncontrasting

confidence: 92%

Ascitic Hepatocyte Growth Factor as a marker for Diagnosis of Spontaneous Bacterial Peritonitis in Cirrhotic Patients

Sorour

Ahmed

Marzaban

et al. 2019

Egyptian Journal of Medical Microbiology

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Background: Spontaneous bacterial peritonitis (SBP) is a common and potentially lethal complication of decompensated cirrhosis. Hepatocyte growth factor (HGF) is a protein produced by mesenchymal cells, and regulated by different physiological and pathological conditions e.g pregnancy, aging and infections. Objective: This study evaluated ascitic HGF as a local marker in diagnosis of SBP. Methodology: Eighty cirrhotic ascitic patients were divided equally into 40 patients with SBP and 40 without. All involved patients were subjected to assay of ascitic HGF using ELISA technique. Results: Ascitic HGF was significantly related to SBP (P=0.000). The sensitivity and specificity of HGF for differentiating SBP were 80 and 82.5%, respectively, at a cut-off value of 2981.34 pg/ml. There was a significant positive correlation between ascitic HGF and TLC (P=0.018), and transaminases; AST and ALT (P =0.007 and P=0.023 respectively). Conclusion: Ascitic HGF is a reliable minimally invasive biomarker for diagnosis of SBP in cirrhotic patients.

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Section: Discussioncontrasting

confidence: 92%

Ascitic Hepatocyte Growth Factor as a marker for Diagnosis of Spontaneous Bacterial Peritonitis in Cirrhotic Patients

Sorour

Ahmed

Marzaban

et al. 2019

Egyptian Journal of Medical Microbiology

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“…Normal koşularda sağlıklı bireylerde serum veya plazmada CRP çok düşük konsantrasyonlarda (100 mg/ml'den küçük) bulunur. İmmünokompetan hastalarda infl amatuar reaksiyonun ya da doku hasarının başlamasından 4-6 saat sonra CRP düzeyi yükselmeye başlar, 24-48 saat içinde zirve değerleri bazal değerlerinin 100-1000 katına çıkar ve yarı ömrü yetişkinlerde yaklaşık 19, yenidoğanlarda 12 saattir (3,9,10). Bakteriyel infeksiyonların akut evresinde CRP düzeyleri orta derece ya da fazla miktarda yükselirken, viral infeksiyonlarda normal ya da hafi f artmış olarak saptanmaktadır (11).…”

Section: İrdelemeunclassified

Levels of Acute Phase Reactants in Patients with Acute Brucellosis

Ulug¹,

Can-Uluğ²,

Selek³

2010

Klimik Dergisi

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ÖzetAmaç: İnfeksiyon, doku hasarı, immünolojik tepkimeler ve inflamatuar süreç organizmada kısa sürede ortaya çıkan ve genel olarak akut faz yanıtı denen sistemik bir yanıta yol açar. Bu çalışmada akut brusellozlu hastalarda C-reaktif protein (CRP), ferritin ve fi brinojen gibi akut faz reaktanlarının düzeyinin saptanması amaçlanmıştır. Yöntemler: Bu çalışma, İnfeksiyon Hastalıkları ve Nöroloji Kliniklerinde, Nisan 2007 ve Ağustos 2008 tarihleri arasında izlenen 48 akut bruselloz olgusu (27 kadın, 21 erkek) ve 42 sağlıklı (22 kadın, 20 erkek) kişiden oluşan kontrol grubuyla yapılmıştır. Bulgular: Brusellozlu hastalarda albümin düzeyleri, kontrol grubuna göre istatistiksel olarak daha düşük (p<0.001), CRP ve ferritin düzeyleri ise daha yüksek bulunmuştur (p<0.001 ve p=0.03). Sonuçlar: Akut brusellozlu hastalarda serum CRP ve ferritin düzeyinin arttığı, albümin düzeyinin ise azaldığı tespit edilmiştir. Klimik Dergisi 2010; 23(2): 48-50.Anahtar Sözcükler: Bruselloz, akut faz reaktanları, C-reaktif protein, ferritin. AbstractObjective: Infection, tissue damage, immunologic reactions and the infl ammatory process rapidly cause a systemic response in the organism, generally termed as acute phase response. The aim of this study was to evaluate the levels of acute phase reactants such as C-reactive protein (CRP), ferritin and fi brinogen in patients with acute brucellosis. Methods: This study was carried out in 48 patients (27 female, 21 male) with acute brucellosis who were followed at the Departments of Infectious Diseases and Neurology, between April 2007 and August 2008, and in 42 healthy controls (22 female, 20 male). Results: Serum albumin levels signifi cantly decreased (p<0.001), whereas CRP and ferritin levels signifi cantly increased (p<0.001 and p=0.03) in patients with acute brucellosis. Conclusions: It was concluded that serum levels of CRP and ferritin increased, while albumin decreased in patients with acute brucellosis. Klimik Dergisi 2010; 23(2): 48-50.

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“…The results of the present study suggest that HGF may also be useful to assess the efficacy of azithromycin administration to MP patients. HGF has previously been used to evaluate the effectiveness of treatment in patients with acute brucellosis and acute myocardial infarction (48,49). Though this suggests that HGF is a general indicator for inflammation or the immune response the results of the present study indicated that HRP had a higher sensitivity and specificity than CRP in assessing efficacy of azithromycin treatment of MP.…”

Section: Mp Severity ------------------------------------------------mentioning

confidence: 50%

Hepatocyte growth factor can guide treatment of Mycoplasma pneumoniae pneumonia in children

Liu

Wang

Yao³

2020

Exp Ther Med

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The objective of the present study was to explore the role of hepatocyte growth factor (HGF) in directing treatment of Mycoplasma pneumoniae pneumonia (MP). Serum levels of HGF were assessed using ELISA in 65 pediatric patients with MP, 42 with bacterial pneumonia and 30 healthy controls. Serum levels of C-reactive protein (CRP), the standard guide for MP treatment, were also examined in severe and non-severe MP. The sensitivity and specificity of HGF and CRP in assessing the outcome of azithromycin treatment of MP were compared using receiver operating characteristic curves. HGF levels were elevated in MP and bacterial pneumonia patients compared with healthy controls. HGF levels were also significantly higher in severe MP than in non-severe MP. HGF showed higher sensitivity and specificity than CRP in assessing outcomes of azithromycin treatment of MP. The results of the present study indicated that HGF may be used to detect severe MP and to direct its management. Furthermore, HGF may be better predictive marker to assess the effectiveness of azithromycin treatment of MP than CRP.

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Hepatocyte growth factor (HGF) in patients with acute brucellosis

Cited by 5 publications

References 12 publications

Ascitic Hepatocyte Growth Factor as a marker for Diagnosis of Spontaneous Bacterial Peritonitis in Cirrhotic Patients

Ascitic Hepatocyte Growth Factor as a marker for Diagnosis of Spontaneous Bacterial Peritonitis in Cirrhotic Patients

Levels of Acute Phase Reactants in Patients with Acute Brucellosis

Hepatocyte growth factor can guide treatment of Mycoplasma pneumoniae pneumonia in children

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