Hepatocyte growth factor (HGF/SF) in Alzheimer's disease

Alleviation of Aβ-induced cognitive impairment by ultrasound-mediated gene transfer of HGF in a mouse model

“…In AD cases, HGF was immunostained near both astrocytes and microglial cells. 43 Astrocytes expressed HGF 43, and HGF induced actin reorganization and chemokinesis in astrocytes. 44 As astrocytes play an important role in central nervous system regeneration, 45 HGF may have more potent neuroprotective actions.…”

“…11 In a previous report, HGF concentration was reported to be increased in the cerebrospinal fluid of AD patients. 43 The authors suggested that the increase in cerebrospinal fluid HGF corresponded to white matter damage. In contrast, HGF level in the brain was decreased after Ab(1-40) injection in our model.…”

Schizophrenia-Like Features in Transgenic Mice Overexpressing Human HO-1 in the Astrocytic Compartment

“…(1) For standard perfusion, mouse brains were fixed by transcardial perfusion as previously described (Fenton et al, 1998) with minor modifications. Briefly, the animals were deeply anesthetized with rodent mixture containing ketamine, xylazine, acepromazine, and saline and perfused with 200 ml of ice-cold saline followed by 250 ml of cold 4% paraformaldehyde in 0.1 M PBS, pH 7.4, for light-microscopic analysis, or cold 2.5% glutaraldehyde in 0.1 M sodium cacodylate buffer, pH 7.5, containing 0.1% CaCl 2 for transmission electron microscopy (TEM).…”

Stage specificity of novel growth factor expression during development of proliferative vitreoretinopathy

“…7,10,11 In the case of platelet-derived growth factor, all three substrate forms (PDGF-AA, PDGF-BB, PDGF-AB) 12,8 have been identified, with PDGF-AA recently believed to play critical role in PVR development. 13 The receptors for these growth factors, as well as the mRNA sequences which code for them, have been located in RPE 9,[14][15][16] and glial cells 9,17 using immunohistochemistry and in situ hybridization.…”