2016
DOI: 10.3892/ijmm.2016.2708
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Hepatocyte growth factor inhibits hypoxia/reoxygenation-induced activation of xanthine oxidase in endothelial cells through the JAK2 signaling pathway

Abstract: Vascular endothelial cells (ECs) appear to be one of the primary targets of hypoxia/reoxygenation (H/R) injury. In our previous study, we demonstrated that hepatocyte growth factor (HGF) exhibited a protective effect in cardiac microvascular endothelial cells (CMECs) subjected to H/R by inhibiting xanthine oxidase (XO) by reducing the cytosolic Ca2+ concentration increased in response to H/R. The precise mechanisms through which HGF inhibits XO activation remain to be determined. In the present study, we exami… Show more

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Cited by 7 publications
(5 citation statements)
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“…Zhang et al . () reported similar findings of decreased XDH activity with inhibition of JAK2 in endothelial cells. The JAK/STAT pathway is also involved in metabolic reprogramming and resistance to therapies in solid tumors (Bourgeais et al ., ; Quintás‐Cardama and Verstovsek, ; Thomas et al ., ; Wang et al ., ; Yu and Jove, ).…”
Section: Resultssupporting
confidence: 65%
See 1 more Smart Citation
“…Zhang et al . () reported similar findings of decreased XDH activity with inhibition of JAK2 in endothelial cells. The JAK/STAT pathway is also involved in metabolic reprogramming and resistance to therapies in solid tumors (Bourgeais et al ., ; Quintás‐Cardama and Verstovsek, ; Thomas et al ., ; Wang et al ., ; Yu and Jove, ).…”
Section: Resultssupporting
confidence: 65%
“…() and Zhang et al . (), JAK2 inhibitors help to deactivate XDH and increase the efficacy of inhibition of XDH by allopurinol.…”
Section: Resultsmentioning
confidence: 99%
“…By accumulating calcium, these two processes can significantly increase the O 2 ·– formation. Finally, H 2 O 2 can be produced by catalyzing O 2 ·– with superoxide dismutase and finally drained from the cell. …”
Section: Resultsmentioning
confidence: 99%
“…melitensis 16M infection resulted in higher cell apoptosis, suggesting that AIR domain were involved in cell apoptosis. The dynamics of ROS determines the different reactions of cells in response to the same signal and inherent ROS levels can determine the sensitivity of certain cells to a particular signal[34]. In our current findings, the ratio of Bax/Bcl-2 in the I-A, O-A, and OA-IA groups was significantly higher than in the control group, indicating that Bcl-2 can inhibit ROS induction, which is consistent with previous research results[35].…”
Section: Discussionmentioning
confidence: 99%