Hepatocyte Growth Factor Is a Better Indicator of Therapeutic Response than C-Reactive Protein within the First Day of Treatment in Pneumonia

Abednazari, Hossein; Xu, Jun; Millinger, Eva; Brudin, Lars; Forsberg, Pia; Nayeri, Fariba

doi:10.1159/000094868

Cited by 9 publications

(12 citation statements)

References 33 publications

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“…During chronic inflammation, HGF may have the ability to bind to c-Met but be unable to induce cell signalling due to deficient ligation to the co-receptor HSPG. HGF is produced rapidly after injury and ongoing damage, acting as an acute phase protein, and our present data is in agreement with our previous observations that HGF may be a more sensitive marker for monitoring the effect of treatment than CRP [35] (Table 2). Furthermore, knock-out mice lacking the HGF gene do not survive [36], and HGF administration has been used to inhibit and treat several injuries, thus acting as a potent growth factor [10].…”

Section: Discussionsupporting

confidence: 93%

Differences in the expression of hepatocyte growth factor in acute and chronic bowel inflammation—Implications for diagnosis?

Lönn¹,

Nakka²,

Olsson³

et al. 2013

ABB

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Background: Hepatocyte growth factor (HGF) acts as an acute phase protein with regenerative properties. HGF is produced systemically and locally during inflammation but exhibits decreased binding affinity to heparan sulphate proteoglycan (HSPG)/glycosaminoglycan during chronic inflammation. We previously observed a high faecal concentration and binding affinity of HGF to HSPG during acute gastroenteritis. High faecal concentrations of calprotectin and HGF have been reported in chronic inflammatory bowel disease (IBD). Methods: Stool samples from patients with ulcerative colitis in remission (n = 11) or exacerbation (n = 5), microscopic colitis (n = 11), colon cancer (n = 6), or acute gastroenteritis caused by Clostridium difficile (n = 20), as well as healthy controls (n = 7), were analysed for the presence of HGF by ELISA, surface plasmon resonance, SDS-PAGE, and Western blot. Then in two patients with ulcerative colitis exacerbation and C. difficile infection, the expression of HGF and calprotectin was studied in colonic biopsies. Results: The faecal concentration of HGF was significantly higher in patients with ulcerative colitis compared to the other groups. The binding affinity to dextran was lower in all groups compared to acute inflammation. HGF receptor binding was similar across groups. In a patient with concomitant C. difficile infection and distal ulcerative colitis, HGF was highly expressed in the part of the bowel unaffected by ulcerative colitis, but no expression was found at the site of chronic inflammation. In the patient with total colitis the biopsies showed low expression of HGF. The areas with chronic inflammation exhibited infiltrating calprotectin-stained neutrophils. Conclusion: HGF is produced locally during inflammation of the bowel. The HGF produced during acute inflammation or exacerbations of chronic inflammation by the unaffected area shows binding affinity to glucosaminoglycans. Measuring HGF binding in faeces and biopsies may be a tool for differentiating between acute and chronic bowel inflammation, which should be assessed thoroughly in future studies.

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Section: Discussionsupporting

confidence: 93%

Differences in the expression of hepatocyte growth factor in acute and chronic bowel inflammation—Implications for diagnosis?

Lönn¹,

Nakka²,

Olsson³

et al. 2013

ABB

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“…Our results from the present study show that monitoring of HGF concentrations predicted the effect of anti-biotic treatment in lung infections with high sensitivity. These results are in agreement with our previous observations [14] [15] and show that monitoring HGF during pneumonia might be a reasonable approach to evaluate therapy. Further studies are needed to determine if HGF has a role in the evaluation of empiric antibiotic treatment in infections caused by multiple resistant microorganisms.…”

Section: Parametersupporting

confidence: 93%

“…It was our belief that this property of HGF could be used to predict the efficacy of treatment by monitoring the status of injury, as indicated by changes in HGF concentration. A previous study by us showed that changes in HGF concentration could function as a therapeutic marker in pneumonia [13]- [15]. In the present study, we investigated whether this might apply to other infectious diseases.…”

Section: Discussionmentioning

confidence: 86%

“…We also showed that HGF concentration increased in serum and exhaled-breath condensate in patients with pneumonia [13] and that the amount of HGF decreased markedly within 48 hours of initiation of the appropriate antibiotic therapy [14]. In another study, we showed that HGF predicted the results of antibiotic therapy better than CRP did within 24 hours of initiation of pneumonia treatment [15]. In the present study, we compared the ability of HGF (compared with body temperature, CRP and PCT) to predict the efficacy of antibiotic treatment within 24 hours of treatment initiation in 51 patients with varying infectious diseases.…”

Section: Introductionmentioning

confidence: 74%

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Hepatocyte Growth Factor Is a Reliable Marker for Efficient Anti-Bacterial Therapy within the First Day of Treatment

Abednazari¹,

Brudin²,

Almroth³

et al. 2014

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Rapid diagnosis and choice of appropriate antibiotic treatment might be life-saving in serious infectious diseases. Still the available markers that can evaluate and monitor the diagnosis and treatment are few. Hepatocyte growth factor (HGF) has been studied as a potent regenerative factor produced and released during injuries such as infectious diseases. Monitoring of HGF levels might predict therapy results better than C-reactive protein (CRP) within the first day of treatment in pneumonia. For further investigation of previous observations we aimed to study HGF as a first-day marker in over-representing infectious diseases in comparison to procalcitonin (PCT), CRP and body temperature. Fifty-one patients with community acquired infectious diseases were included consequently at admittance and the serum samples were collected before and within 18 -24 hours of treatment. HGF levels decreased significantly in case of efficient antibiotic therapy and HGF was shown to be better than PCT, CRP and body temperature to evaluate treatment. In patients with pneumonia, monitoring of HGF was most reasonable. HGF might be used as a therapeutic marker within the first day of empiric antibiotic treatment during infection.

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“…It has been shown that HGF is accounted for by malign cell transformation, proliferation, invasion, and metastasis of cancer cells (12,13). It has been reported that HGF levels are increased in sepsis, inflammatory pulmonary diseases, and pneumonia (14,15). Although HGF levels in serum and local fluids have been particularly investigated in acute and chronic inflammatory diseases, there are a limited number of studies on HGF levels and its prognostic value in infectious diseases.…”

Section: Introductionmentioning

confidence: 99%

Investigation of hepatocyte growth factor and proinflammatory cytokine levels in patients with febrile neutropenia

Özden

Gödekmerdan²,

Ilhan³

et al. 2013

Turk J Med Sci

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Three acylhydrazone-based compounds were designed as novel neutral sensors for anions, and synthesized by simple steps in good yields. Their anion recognition properties were studied by UV-vis and 1 H-NMR spectroscopy. The results showed that the receptors 1, 2, and 3 all had a better selectivity for F − and CH 3 COO − , but no evident binding with Cl − , Br − , I − , NO − 3 , H2 PO − 4 , or HSO − 4 . The results indicated that anion recognition was achieved via convergent hydrogen bond interactions from acylhydrazone functionality on the side arms. The UV-vis data indicated that a 1:1 stoichiometry complex was formed between compounds 1, 2, or 3 and anions. The binding and selectivity were also tuned by the change of the place of the nitro group attached to the phenyl. Moreover, receptor 3 can act as the colorimetric sensor for such anions as F − and CH 3 COO − , and the recognition mechanism and binding mode were discussed.

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Hepatocyte Growth Factor Is a Better Indicator of Therapeutic Response than C-Reactive Protein within the First Day of Treatment in Pneumonia

Cited by 9 publications

References 33 publications

Differences in the expression of hepatocyte growth factor in acute and chronic bowel inflammation—Implications for diagnosis?

Differences in the expression of hepatocyte growth factor in acute and chronic bowel inflammation—Implications for diagnosis?

Hepatocyte Growth Factor Is a Reliable Marker for Efficient Anti-Bacterial Therapy within the First Day of Treatment

Investigation of hepatocyte growth factor and proinflammatory cytokine levels in patients with febrile neutropenia

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