2024
DOI: 10.1111/jre.13237
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Hepatocyte growth factor is protective in early stage but bone‐destructive in late stage of experimental periodontitis

Xiaomin Zhao,
Weijia Liu,
Zhicong Wu
et al.

Abstract: Background and ObjectiveClinical studies found high levels of hepatocyte growth factor (HGF) expression in patients with periodontitis. Studies suggest that HGF plays an important role in periodontitis, is involved in inflammation, and modulates alveolar bone integrity in periodontitis. This study aims to investigate the effects and mechanisms of HGF in the progression of experimental periodontitis.MethodsWe used silk thread ligation to induce periodontitis in HGF‐overexpressing transgenic (HGF‐Tg) and wild‐ty… Show more

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