Hepatocyte nuclear factor 4 a (HNF4α): A perspective in cancer

Qu, Ningxin; Luan, Ting; Liu, Naiquan; Kong, Chenhui; Xu, Le; Yu, Hong; Kang, Ye; Han, Ye

doi:10.1016/j.biopha.2023.115923

Cited by 2 publications

(1 citation statement)

References 103 publications

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“…These ndings underscore Cisd2 as a promising therapeutic target to decelerate liver aging. In addition, studies have consistently indicated that reduced HNF4α expression is associated with diverse liver pathological conditions, underscoring its role in preserving liver homeostasis 46,47 . A study by Melis et al 48 demonstrated HNF4α downregulation in chronic liver diseases, while Lu et al 18 emphasized its crucial role in preventing the onset of fatty liver and maintaining lipid metabolism.…”

Section: Discussionmentioning

confidence: 99%

The Synergistic Impact of Probiotic Supplementation and High-intensity Interval Training on Dyslipidemia and the Liver Longevity Genes in Ovariectomized Rats

Abbaspour,

Karimzadhagh,

Bayat

et al. 2024

Preprint

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Objective: This study aimed to explore the synergistic impact of supplementing with local probiotic consumption and engaging in high-intensity interval training (HIIT) on liver health. The focus was particularly on targeting the revitalization genes Cisd2 and Hnf4α and improving dyslipidemia. Methods: In this study, forty ovariectomized (OVX) Wistar rats were divided into five groups: one control, sham surgery, and four ovariectomized (OVX) groups receiving either 1 ml of synthesized local probiotic or engaged in HIIT at 90-95% VO2 max for eight weeks and finally co-treatment of exercise and probiotics. Following the interventions, protein expressions were measured using Western blotting, and assessments of lipid profiles were conducted using colorimetric analysis and enzyme-linked immunosorbent assay. Results: Western blot analysis demonstrated a notable increase in Cisd2 and Hnf4a levels following the co-administration of HIIT and probiotics compared to the OVX + Vehicle group (P=0.001). Furthermore, the analysis revealed a significant decrease in weight, WC, visceral fat, BMI, TG, TC, and LDL-C concentrations, coupled with increased HDL-C (P = 0.001). Conclusion: Our study indicates the efficacy of combined HIIT and lactobacillus probiotic treatment in elevating liver longevity markers of Cisd2 and Hnf4a and mitigating factors associated with obesity and dyslipidemia.

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Section: Discussionmentioning

confidence: 99%

The Synergistic Impact of Probiotic Supplementation and High-intensity Interval Training on Dyslipidemia and the Liver Longevity Genes in Ovariectomized Rats

Abbaspour,

Karimzadhagh,

Bayat

et al. 2024

Preprint

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Long Non-Coding RNAs in Kidney Injury: A Comprehensive Review

Bhat,

Shanbhag

2024

JPDMHD

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Kidney injury, a global health challenge, necessitates a nuanced understanding of molecular intricacies for effective interventions. Long non-coding RNAs (lncRNAs), once dismissed as transcriptional noise, now emerge as pivotal players in orchestrating renal health. Dysregulation of specific lncRNAs like TUG1, MALAT1, H19, and NEAT1 provides molecular signatures, distinguishing physiological states from pathological conditions. In acute kidney injury (AKI), TUG1 and MALAT1 regulate apoptosis, inflammation, and fibrosis. Chronic kidney disease (CKD) involves lncRNAs like H19 and NEAT1 modulating cell proliferation and apoptosis. Beyond diagnostics, lncRNAs actively shape inflammation, apoptosis, and fibrosis, positioning them as master regulators in the intricate ballet of kidney health. Recent strides in research, coupled with cutting-edge genomics and bioinformatics tools, highlight their roles and therapeutic potential. Challenges in understanding their intricate roles and interactions necessitate the exploration of promising avenues, including single-cell RNA sequencing and artificial intelligence, paving the way for personalized interventions and regenerative medicine in kidney diseases.

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Hepatocyte nuclear factor 4 a (HNF4α): A perspective in cancer

Cited by 2 publications

References 103 publications

The Synergistic Impact of Probiotic Supplementation and High-intensity Interval Training on Dyslipidemia and the Liver Longevity Genes in Ovariectomized Rats

The Synergistic Impact of Probiotic Supplementation and High-intensity Interval Training on Dyslipidemia and the Liver Longevity Genes in Ovariectomized Rats

Long Non-Coding RNAs in Kidney Injury: A Comprehensive Review

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