Hepatocyte proliferation favours viral clearance in young children with chronic hepatitis B virus infection

Wang, Limin; Liu, Shuhong; Wang, Chunya; Zhu, Min; Guo, Yupeng; Zhao, Pan

doi:10.1111/apa.16572

Cited by 2 publications

(2 citation statements)

References 21 publications

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“…In our study, FHIT was a high‐frequency integrated gene among infant patients, but it has rarely been reported as one of the main target human genes in adult patients with chronic hepatitis B. FHIT is a tumor suppressor gene with roles in cell proliferation and apoptosis 23,24 . In our recently published study, we found that hepatocyte proliferation favored HBV clearance in young children with chronic HBV infection 25 . Whether and how the integration of HBV DNA into FHIT affects hepatocyte proliferation or hepatitis B prognosis deserves further study.…”

Section: Discussionmentioning

confidence: 62%

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Juveniles, young adults, and infants with hepatitis B virus infection: A genomic study

Zhang,

Li,

Liu

et al. 2024

Journal of Medical Virology

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Integration of hepatitis B virus (HBV) DNA into the human genome is recognized as an oncogenic factor and a barrier to hepatitis B cure. In the study, biopsy liver tissues were collected from adolescents and young adults with acute HBV infection younger than or equal to 35 years of age and from HBV‐infected infant patients younger than or equal to 6 months of age. A high‐throughput sequencing method was used to detect HBV DNA integration. Totally, 12 adolescents, young adults, and 6 infants were included. Among the 12 patients with acute HBV infection, immunohistochemical staining of intrahepatic hepatitis B surface antigen for all displayed negative results, and no HBV DNA integrants in the hepatocyte DNA were confirmed. All infant patients had elevated levels of alanine aminotransferase and high levels of serum HBV DNA. Numerous gene sites of hepatocyte DNA were integrated by HBV DNA for each infant patient, ranging from 120 to 430 integration sites. The fragile histidine triad gene was the high‐frequency integrated site in the intragenic region for infant patients. In conclusion, hepatocyte DNA is integrated by HBV DNA in babies with active hepatitis B but seems seldom affected among adolescents and young adults with acute HBV infection. Infantile hepatitis B should be taken seriously considering abundant HBV DNA integration events.

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Section: Discussionmentioning

confidence: 62%

“…23,24 In our recently published study, we found that hepatocyte proliferation favored HBV clearance in young children with chronic HBV infection. 25 Whether F I G U R E 5 Fragile histidine triad (FHIT) gene is the high-frequency integrated site at the intragenic region among infant patients.…”

Section: Discussionmentioning

confidence: 99%

Juveniles, young adults, and infants with hepatitis B virus infection: A genomic study

Zhang,

Li,

Liu

et al. 2024

Journal of Medical Virology

Self Cite

View full text Add to dashboard Cite

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Epidemiology, Natural History, and Outcome of Chronic Hepatitis B in Children

Huang,

Li,

Zhang

et al. 2024

Infectious Diseases &Amp; Immunity

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Hepatitis B virus (HBV) infection is a global epidemic whose prevention and control among children warrant significant attention. Despite the availability of effective vaccines, the disease continues to affect millions of children worldwide, underscoring the need for a comprehensive understanding of its epidemiology and natural history in this vulnerable population. While research on HBV in adults has advanced considerably, the natural history of HBV infection in children remains less well-defined and may differ from adult studies due to unique immunological and physiological characteristics. This article reviews the epidemiological characteristics of HBV infection in children worldwide and summarizes the research progress on the natural outcomes of children with chronic HBV infection. Furthermore, the necessity of this review stems from the critical role that early detection, monitoring, and timely intervention play in mitigating the long-term consequences of chronic hepatitis B (CHB) in children. By synthesizing current evidence and identifying knowledge gaps, we hope to inform clinical practice, guide future research directions, and ultimately improve the health outcomes of children living with HBV. In doing so, this review article offers a valuable reference for healthcare providers, researchers, and policymakers working to combat the global challenge of HBV infection among children. The aim is to provide a relevant reference for the monitoring, screening, diagnosis, and treatment of children with CHB.

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Hepatocyte proliferation favours viral clearance in young children with chronic hepatitis B virus infection

Cited by 2 publications

References 21 publications

Juveniles, young adults, and infants with hepatitis B virus infection: A genomic study

Juveniles, young adults, and infants with hepatitis B virus infection: A genomic study

Epidemiology, Natural History, and Outcome of Chronic Hepatitis B in Children

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