Hepatocyte SREBP signaling mediates clock communication within the liver

Guan, Dongyin; Bae, Hosung; Zhou, Dishu; Chen, Ying; Jiang, Chunjie; La, Cam Mong; Xiao, Yang; Zhu, Kexin; Hu, Wenxiang; Trinh, Trang Minh; Li, Panpan; Xiong, Ying; Cai, Bolin; Jang, Cholsoon; Lazar, Mitchell A.

doi:10.1172/jci163018

Cited by 8 publications

(7 citation statements)

References 67 publications

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“…The hepatocyte clock plays a vital role in sustaining rhythmic gene expression patterns in immune cells. Specifically, hepatocyte‐specific knockout of Rev‐erbs leads to marked changes in the rhythmic gene expression profiles of nonparenchymal liver cells, with macrophages being notably affected 124 . Hepatocyte‐targeted Rev‐erbs knockdown disrupts the rhythmicity of genes linked to the vitamin D receptor signaling pathway, a pathway known to mitigate liver inflammation and steatosis.…”

Section: Circadian Regulation Of Non‐immune Cell Functionmentioning

confidence: 99%

“…Hepatocyte‐targeted Rev‐erbs knockdown disrupts the rhythmicity of genes linked to the vitamin D receptor signaling pathway, a pathway known to mitigate liver inflammation and steatosis. It also enhances the circadian rhythmicity of genes associated with inflammatory responses in macrophages 124–126 . The interplay between hepatocytes and macrophages, facilitated by mediators including hepatocyte‐derived sterol regulatory‐element binding protein (SREBP) cleavage‐activating protein and a range of polypeptides, plays a critical role in the transmission of circadian rhythmic signals 124 .…”

Section: Circadian Regulation Of Non‐immune Cell Functionmentioning

confidence: 99%

“…Specifically, hepatocyte‐specific knockout of Rev‐erbs leads to marked changes in the rhythmic gene expression profiles of nonparenchymal liver cells, with macrophages being notably affected. 124 Hepatocyte‐targeted Rev‐erbs knockdown disrupts the rhythmicity of genes linked to the vitamin D receptor signaling pathway, a pathway known to mitigate liver inflammation and steatosis. It also enhances the circadian rhythmicity of genes associated with inflammatory responses in macrophages.…”

Section: Circadian Regulation Of Non‐immune Cell Functionmentioning

confidence: 99%

“…It also enhances the circadian rhythmicity of genes associated with inflammatory responses in macrophages. 124 , 125 , 126 The interplay between hepatocytes and macrophages, facilitated by mediators including hepatocyte‐derived sterol regulatory‐element binding protein (SREBP) cleavage‐activating protein and a range of polypeptides, plays a critical role in the transmission of circadian rhythmic signals. 124 In conclusion, circadian clocks are integral to the regulation of gene expressions and cellular functions in hepatocytes, underscoring their role in maintaining hepatic and systemic physiological balance.…”

Section: Circadian Regulation Of Non‐immune Cell Functionmentioning

confidence: 99%

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The role of circadian clock in regulating cell functions: implications for diseases

Lin,

He,

Cai

et al. 2024

MedComm

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The circadian clock system orchestrates daily behavioral and physiological rhythms, facilitating adaptation to environmental and internal oscillations. Disruptions in circadian rhythms have been linked to increased susceptibility to various diseases and can exacerbate existing conditions. This review delves into the intricate regulation of diurnal gene expression and cell function by circadian clocks across diverse tissues. . Specifically, we explore the rhythmicity of gene expressions, behaviors, and functions in both immune and non‐immune cells, elucidating the regulatory effects and mechanisms imposed by circadian clocks. A detailed discussion is centered on elucidating the complex functions of circadian clocks in regulating key cellular signaling pathways. We further review the circadian regulation in diverse diseases, with a focus on inflammatory diseases, cancers, and systemic diseases. By highlighting the intimate interplay between circadian clocks and diseases, especially through clock‐controlled cell function, this review contributes to the development of novel disease intervention strategies. This enhanced understanding holds significant promise for the design of targeted therapies that can exploit the circadian regulation mechanisms for improved treatment efficacy.

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Section: Circadian Regulation Of Non‐immune Cell Functionmentioning

confidence: 99%

Section: Circadian Regulation Of Non‐immune Cell Functionmentioning

confidence: 99%

Section: Circadian Regulation Of Non‐immune Cell Functionmentioning

confidence: 99%

Section: Circadian Regulation Of Non‐immune Cell Functionmentioning

confidence: 99%

See 2 more Smart Citations

The role of circadian clock in regulating cell functions: implications for diseases

Lin,

He,

Cai

et al. 2024

MedComm

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“…It is also not surprising that all three factors can directly regulate the synthesis, elimination, and fusion dynamics of mitochondria (110,160,161). SREBP1, an essential regulator of cholesterol and fatty acid metabolism, has recently been shown to mediate circadian remodeling and maladaptive response to the over-nutritional environment of non-alcoholic fatty liver disease, which is a major risk of liver cancer (162).…”

Section: Metabolismmentioning

confidence: 99%

E-box binding transcription factors in cancer

2023

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E-boxes are important regulatory elements in the eukaryotic genome. Transcription factors can bind to E-boxes through their basic helix-loop-helix or zinc finger domain to regulate gene transcription. E-box-binding transcription factors (EBTFs) are important regulators of development and essential for physiological activities of the cell. The fundamental role of EBTFs in cancer has been highlighted by studies on the canonical oncogene MYC, yet many EBTFs exhibit common features, implying the existence of shared molecular principles of how they are involved in tumorigenesis. A comprehensive analysis of TFs that share the basic function of binding to E-boxes has been lacking. Here, we review the structure of EBTFs, their common features in regulating transcription, their physiological functions, and their mutual regulation. We also discuss their converging functions in cancer biology, their potential to be targeted as a regulatory network, and recent progress in drug development targeting these factors in cancer therapy.

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Liver as a nexus of daily metabolic cross talk

Litwin,

Koronowski

2024

International Review of Cell and Molecular Biology

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Hepatocyte SREBP signaling mediates clock communication within the liver

Cited by 8 publications

References 67 publications

The role of circadian clock in regulating cell functions: implications for diseases

The role of circadian clock in regulating cell functions: implications for diseases

E-box binding transcription factors in cancer

Liver as a nexus of daily metabolic cross talk

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