2023
DOI: 10.1002/mnfr.202200562
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Hepatoenteric Protective Effect of Melanin from Inonotus hispidus on Acute Alcoholic Liver Injury in Mice

Abstract: Scope Alcoholic liver disease (ALD) is a common disease with a high incidence. Because traditional drugs have obvious side effects, it is desired to find more effective drugs. Methods and results This study investigates the effects of melanin from Inonotus hispidus fruiting bodies (IHFM) on acute alcoholic injury mice and detects the protective mechanisms via the gut–microbiota–liver axis. The results show that IHFM alleviates mouse liver injury by enhancing alcohol metabolism capacity, reducing inflammation r… Show more

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Cited by 5 publications
(3 citation statements)
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“…The study on the protecting mechanism of Inonotus hispidus against acute alcoholic liver injury additionally mentioned its ability to upregulate L. johnsonii abundance to safeguard mice from acute alcoholic liver injury [85]. A similar potential mechanism of action was additionally seen in the BaWeiBaiDuSan (BWBDS) protection against sepsis-induced liver injury (SILI) in mice [11].…”
Section: Liver Diseasesmentioning
confidence: 95%
“…The study on the protecting mechanism of Inonotus hispidus against acute alcoholic liver injury additionally mentioned its ability to upregulate L. johnsonii abundance to safeguard mice from acute alcoholic liver injury [85]. A similar potential mechanism of action was additionally seen in the BaWeiBaiDuSan (BWBDS) protection against sepsis-induced liver injury (SILI) in mice [11].…”
Section: Liver Diseasesmentioning
confidence: 95%
“…Indeed, in the medical realm, eumelanin has already been explored as thermo-and/or photostabilizers, [45][46][47] bioremediation, [48][49][50] matrix for bactericidal systems, 51 controlled drug delivery, 52,53 photothermal therapeutic agent, [54][55][56] and reduced inammation. 57,58 Eumelanin also showed photoconversion 59 and energy storage capabilities. [60][61][62][63] For instance, using an eumelanin anode (0.6 g of active material) along with a manganese oxide cathode could sustain 5 mW of power for 20 hours.…”
Section: Eumelanin In Focusmentioning
confidence: 99%
“…Indeed, in the medical realm, eumelanin has already been explored as thermo- and/or photostabilizers, 45–47 bioremediation, 48–50 matrix for bactericidal systems, 51 controlled drug delivery, 52,53 photothermal therapeutic agent, 54–56 and reduced inflammation. 57,58…”
Section: Eumelanin In Focusmentioning
confidence: 99%