Hepatogenous diabetes. Current views of an ancient problem

García-Compeán, Diego; Jáquez-Quintana, Joel Omar; Maldonado-Garza, Héctor Jesús

doi:10.1016/s1665-2681(19)31805-8

Cited by 84 publications

(72 citation statements)

References 66 publications

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“…Of all the cirrhotic patients, 28.86% had DM. Further, the percentage of HCV-related LC cases among these DM cases was the highest; this result is consistent with those of a previous report [1,[3][4][5][6][7]. Despite the fact that HBV is not suggested to be a risk factor for DM, 29.3% of HBVrelated cirrhotic patients had DM in the present study.…”

Section: Discussionsupporting

confidence: 92%

“…In the study subjects, we found a significantly higher prevalence rate of DM in cirrhotic patients than in the general population. This suggested that hepatogenous diabetes may account for a certain proportion of cirrhosis cases with DM in Taiwan. DM could be a complication of hepatogenous diabetes, and the etiology of cirrhosis, that is, NAFLD, hepatitis C, hemochromatosis, and alcoholic, is crucial in this regard [1,[3][4][5][6][7]. HBV infection, however, shows conflicting evidence as to whether there is an increased prevalence of DM.…”

Section: Discussionmentioning

confidence: 99%

“…The high prevalence of glucose intolerance called hepatogenous diabetes is originally reported by Megyesi et al [4]. Since then, increasing literatures have confirmed this finding, therefore it has been suggested that up to 96% of the patients with liver cirrhosis (LC) may have glucose intolerance, and 30% could be clinically diagnosed as DM [5][6][7]. However, cirrhosis alone does not always induce DM; the etiology of liver disease and environmental factors may play a major role.…”

Section: Introductionmentioning

confidence: 95%

“…The etiology of LC is frequently associated with the prevalence of DM, such as non-alcoholic fatty liver disease (NAFLD), alcoholic hepatitis, hepatitis C virus (HCV) infection, and hemochromatosis [1,3,[5][6][7]. With regard to hepatitis B virus (HBV) infection, however, there is conflicting evidence as to whether it results in an increased prevalence of type 2 DM.…”

Section: Introductionmentioning

confidence: 99%

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The dissociation between the diabetes and both Child–Pugh score and in-hospital mortality in cirrhotic patients due to hepatitis B, hepatitis C, or alcoholic

Chen

Wang

et al. 2011

Hepatol Int

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The prevalence of diabetes was higher in cirrhotic patients in Taiwan. The prevalence of diabetes was dissociated with Child-Pugh or MELD score. The diagnosis of diabetes did not affect the renal function or in-hospital mortality in cirrhotic patients. Since the clinical outcomes of diabetes were different from cirrhotic patients to general population, it is unclear whether the treatment of diabetes and improved glycemic control will benefit cirrhotic patients.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The dissociation between the diabetes and both Child–Pugh score and in-hospital mortality in cirrhotic patients due to hepatitis B, hepatitis C, or alcoholic

Chen

Wang

et al. 2011

Hepatol Int

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“…On one hand, hyperglycemia existing for a long time can cause cellular immunity dysfunction and misadjustment in the ratio of T lymphocytes. On the other hand, the development and prognosis of hepatocellular carcinoma is related to humoral and cellular immunity [12] . HCC patients have cellular immunity dysfunction and a poor anti-tumor immune response.…”

Section: Immunity Dysfunctionmentioning

confidence: 99%

An investigation into disease progression and the correlation between diabetes mellitus and hepatocellular carcinoma

Yang¹,

Hou

Liu

et al. 2009

Clin. Oncol. Cancer Res.

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Diabetes mellitus has been associated with an increased risk of hepatocellular carcinoma in recent studies of patients. At the same time, advanced hepatocellular carcinoma itself can cause glucose intolerance and can aggravate diabetes. Diabetes mellitus inducing hepatocellular carcinoma may result in changes in the following aspects: dysfunction of organism, endocrine hormone balance and interactions, endothelins and so on. One way, diabetes mellitus may induce hepatocellular carcinoma through the effects of chemotherapeutics and other adjuvant drugs. This review outlines the relationship between diabetes mellitus and the risk of hepatocellular carcinoma as well as treatments for hepatocellular carcinoma, which may be helpful for clinicians.

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Adverse impact of carbon tetrachloride on metabolic function in mice

Liang

Liu

et al. 2019

J of Cellular Biochemistry

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Carbon tetrachloride (CCl 4 ), a potent hepatotoxin, is linked to the histopathological outcomes of inflammatory or oxidative stress, and cell death. However, further study of additional dysmetabolism induced by CCl 4 toxicant has not yet been investigated. In current study, chronical and acute exposures of CCl 4 in mice were used to unmask the biological molecular mechanism responsible for insulin-dependent metabolic disorder. In experimental methods, a number of biochemical assays were used in assessment of biological impacts on insulinproduced pancreas and insulin-responsive hepatocyte after long-and short-term exposures of CCl 4 toxicant, respectively. As a result, data from oral glucose tolerance test showed that CCl 4 exposures induced glucose tolerance and disrupted blood insulin and glucagon levels time-dependently. Meanwhile, biochemical and histocytological analyses further indicated that CCl 4 exposures significantly resulted in liver cell damage, induced abnormal changes of hepatic and skeletal glycogen synthesis. In addition, acute CCl 4 -exposed mice showed reduced functional proteins of glucose transporter 2 (GLUT2), insulin receptor β, insulin receptor substrate 1, glycogen synthase kinase 3β (GSK3β), p-AKT Ser473 associated with AKT signaling pathway in liver cells, whereas acute CCl 4 exposure downregulated the endogenous expressions of the insulin and glucagon hormonal proteins in the pancreas. Taken together, the current findings highlight that CCl 4 impaired insulin-dependent glucose homeostasis through modulating hepatocellular AKT signaling pathway in acute CCl 4 exposure and GLUT2/GSK3β pathway in chronic CCl 4 -exposed liver cells. K E Y W O R D Scarbon tetrachloride, dysmetabolism, liver, molecular pathway, pancreas

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Hepatogenous diabetes. Current views of an ancient problem

Cited by 84 publications

References 66 publications

The dissociation between the diabetes and both Child–Pugh score and in-hospital mortality in cirrhotic patients due to hepatitis B, hepatitis C, or alcoholic

The dissociation between the diabetes and both Child–Pugh score and in-hospital mortality in cirrhotic patients due to hepatitis B, hepatitis C, or alcoholic

An investigation into disease progression and the correlation between diabetes mellitus and hepatocellular carcinoma

Adverse impact of carbon tetrachloride on metabolic function in mice

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