Hepatoid adenocarcinoma—Clinicopathological features and molecular characteristics

Li, Ming; Mei, Yanxia; Wen, Jihang; Jiao, Yurong; Pan, Qiangrong; Kong, Xianglong; Li, Jun

doi:10.1016/j.canlet.2023.216104

Cited by 17 publications

(12 citation statements)

References 107 publications

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“…AFP can also be used as an important reference index for post-treatment follow-up of HAS patients. A clear diagnosis before surgery is the primary prerequisite for formulating a correct treatment plan, and enhancement CT and MRI scans are important imaging method for the diagnosis of HAS [1,10,11]. In this patient, the lesions in the antrum and liver were clearly observed on preoperative CT, and the arterial phase enhancement was evident.…”

Section: Discussionmentioning

confidence: 74%

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Hepatoid Adenocarcinoma of the Stomach with Liver and Pulmonary Metastases: A Case Report and Literature Review

Peng,

Zeng,

Qiao

et al. 2024

J Biomed Res Environ Sci

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Hepatoid Adenocarcinoma of the Stomach (HAS) is a rare unique subtype of Gastric Cancer (GC) with a low incidence but a high mortality rate. We report a female case of 67-years-old with APF producing hepatoid adenocarcinoma of the gastric antrum with liver and lung metastases. Abdominal CT of the patient showed multiple liver masses, which were considered as metastatic tumors and proved to be adenocarcinoma by pathological examination of a biopsy. The gastroscopy revealed antral ulcer complicated with bleeding. The biopsy results of hepatoid adenocarcinoma were consistent with the results of liver masses. Moreover, α-Fetoprotein (AFP) increased sharply to 86332 ng/mL. Thus, the diagnosis of gastric hepatoid adenocarcinoma with liver metastasis was established. In terms of treatment, liver TACE embolization was performed first, followed by radical gastrectomy and resection of liver tumor. During the operation, multiple small tumors (less than 5cm in diameter) in the liver were treated by radiofrequency ablation. The patient recovered well after surgery, with a rapid decline in AFP. Postoperative CT indicated the presence of bioactive tumors in the liver and new tumors in the lung. Lung puncture pathology suggests tumor metastasis. Liver and lung were treated with radiofrequency ablation and SOX (Oxaliplatin and Tegacil) chemotherapy. There was no significant recurrence 20 months after surgery, and personalized systematic treatment for this patient was effective. Standard treatment for gastric hepatoid adenocarcinoma has not yet been established, and personalized systematic therapy is the preferred treatment.

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Section: Discussionmentioning

confidence: 74%

“…the stomach (HAS, 63%), followed by the ovaries (10%), lungs (5%), gallbladder (4%), pancreas (4%), uterus (4%) and urinary bladder (3%) [1]. The total incidence of HAS, reported by two studies, was only 1.0% (45/4426) [2] and 0.73% (6/817) [3].…”

Section: Introductionmentioning

confidence: 99%

Hepatoid Adenocarcinoma of the Stomach with Liver and Pulmonary Metastases: A Case Report and Literature Review

Peng,

Zeng,

Qiao

et al. 2024

J Biomed Res Environ Sci

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“…A recent study summarized 39 cases of colorectal HACs reported over the last 30 years (11). In the colon or rectum, 46.2% were located in the right hemicolon, 25.6% in the left hemicolon, and 23.1% in the rectum (11,12).…”

Section: Discussionmentioning

confidence: 99%

Giant hepatoid adenocarcinoma of the transverse colon in an 84- year-old woman: A case report and review of the literature

Lin,

Wang,

Wang

et al. 2024

Preprint

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Background: Hepatoid adenocarcinoma (HAC) is a rare extrahepatic tumor. The most common origin of HAC was the stomach (63%). HACs originating from the colon or rectum are rare. Case presentation: We present a case of an 84-year-old Chinese woman diagnosed with a giant hepatoid adenocarcinoma with chief complaint of a large abdominal mass. A plain CT scan of the region showed an irregularly thickened transverse colon wall with a length of approximately 15 cm in the intestine. The patient underwent an extended right hemicolectomy and partial small intestinal resection. The patient successfully recovered and was discharged. Conclusion: HACs are less likely to occur in the colorectum. We recommend that surgeons intervene aggressively if the patient’s condition permits.

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“…>50 % of HAC/AED cases occur in the stomach, but rarely in other organs including the pancreas [ [6] , [7] , [8] , [9] , [10] ]. However, the frequency of extragastric HAC (EGHAC) is much lower than that of GHAC.…”

Section: Discussionmentioning

confidence: 99%

A case of pancreatic ductal adenocarcinoma with enteroblastic, neuroendocrine, and squamous differentiation with p53 overexpression and loss of Rb expression

Kodama,

Tani,

Yamane

et al. 2024

International Journal of Surgery Case Reports

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Hepatoid adenocarcinoma—Clinicopathological features and molecular characteristics

Cited by 17 publications

References 107 publications

Hepatoid Adenocarcinoma of the Stomach with Liver and Pulmonary Metastases: A Case Report and Literature Review

Hepatoid Adenocarcinoma of the Stomach with Liver and Pulmonary Metastases: A Case Report and Literature Review

Giant hepatoid adenocarcinoma of the transverse colon in an 84- year-old woman: A case report and review of the literature

A case of pancreatic ductal adenocarcinoma with enteroblastic, neuroendocrine, and squamous differentiation with p53 overexpression and loss of Rb expression

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