Hepatoid carcinoma of the ovary: A case report and review of the literature

Abstract

Abstract. Hepatoid carcinoma of the ovary is a type of tumor resembling hepatocellular carcinoma that arises from the ovary. Hepatoid carcinoma patients are predominantly elderly females ranging between 35 and 78 years of age, with an average age of 56 years. It was suggested that, microscopically, bile canalicular structures are rare, but among nine cases examined for bile canalicular structures, four demonstrated a positive result. Here, we report a case of a 55-year-old female who presented to the Second Xiangya Hospital, Changsha, China, with lower abdominal pain, abdominal distention and increasing abdominal girth. The patient underwent total hysterectomy, bilateral salpingo-oophorectomy, omentectomy, tumor debulking and postoperative chemotherapy. A mass in the left ovary measuring approximately 11 cm in diameter was identified. Microscopic and immunohistochemical results suggested that it was a hepatoid carcinoma of the left ovary.

Recurrent ovarian undifferentiated carcinoma resembling hepatoid morphology treated with pegylated liposomal doxorubicin and bevacizumab

“…Of the 33 previously reported cases of primary HCO, both strictly and broadly defined, 14 (>40%) have been described from East Asian countries, including Japan, Korea, Taiwan, and China . One explanation for this regional bias may be that there are environmental or ethnic epidemiological factors at play .…”

Hepatoid Carcinoma of the Ovary: Clinical, Histopathologic, and Immunophenotypic Features

“…Hepatoid carcinoma of the ovary presents at a median age of 57 years (range, 35-78 years), with most patients showing elevated levels of circulating AFP (20 of 22; 90.9%) and/or CA125 (14 of 22; 63.6%). [1][2][3][4][5][6][7][8][9][10][12][13][14][15][16][17][18][19][20][21] Increased serum carcinoembryonic (CEA) and inhibin levels have been demonstrated in 3 and 1 individual cases, respectively. 3,7,10,12 The overwhelming majority of affected women present with disseminated disease involving the pelvis, peritoneum, and invading adjacent organs (Table).…”

“…6,7,18 Median size is 12 cm (range, 5.1-35 cm), and there is bilateral ovarian involvement in 23.8% of cases (5 of 21). 1,3,12,13,17 Microscopically, the most common architectural patterns are solid sheets and trabeculae (Figure 1, A), with occasional neoplasms showing glands and papillary structures. 1,5,10 Most HCOs are monophasic and display a classic hepatoid cytomorphology.…”

Hepatoid Carcinoma of the Pancreas: Case Report, Next-Generation Tumor Profiling, and Literature Review

“…These rare neoplasms, and they may arise in a variety of extrahepatic sites, including the stomach, pancreas, lung, gallbladder, ovary, and colon [1, 2, 3, 4, 5, 6]. The first case reported by Ishikura et al [7] was of a gastric neoplasm with such characteristics.…”