Hepatoid carcinoma of the pancreas

Paner, Gladell P.; Thompson, Karen; Reyes, Cesar V.

doi:10.1002/(sici)1097-0142(20000401)88:7<1582::aid-cncr12>3.0.co;2-a

Cited by 94 publications

(93 citation statements)

References 11 publications

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“…In addition, the fact that cells with features of both acinar/islet cells and hepatocytes were found in the pancreas of rats treated with hypolipidemic drugs could make the presumption that acinar/intermediate cells were precursor cells for hepatocytes. 9 Paner et al 12 reviewed 5…”

Section: Discussionmentioning

confidence: 99%

“…This is supported by the close proximity and common embryonic origin (foregut endoderm) of the liver and pancreas. 6,12 However, since hepatoid carcinoma can be developed in other germ-layer origins of organs, cellular transdifferentiation is a more primordial explanation. The prognosis of hepatoid carcinoma of the pancreas could not be established due to the lack of cases.…”

Section: Discussionmentioning

confidence: 99%

“…Although hepatoid carcinoma of the gastrointestinal tract generally shows poor prognosis, 4 out of 9 cases did not have poor outcome; that is, after the initial diagnosis, 1 survived for 14 months, 1 for 48 months, and the other 2 for 8.5 years and 28 months. 6,[12][13][14] However, their biologic aggressiveness can be predicted through massive lymphatic and venous invasion at the time of diagnosis, resulting in liver and lymph nodes metastasis. Moreover, florid proliferation within local veins mimics the behavior of HCC.…”

Section: Discussionmentioning

confidence: 99%

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Hepatoid Carcinoma of the Pancreas Combined with Neuroendocrine Carcinoma

Jung

Kim

et al. 2010

Gut Liver

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Hepatoid carcinoma is a primary extrahepatic carcinoma whose morphology, immunohistochemistry, and behavior are similar to those of hepatocellular carcinoma. The most common sites of extrahepatic carcinoma are the stomach and ovary, but nine cases of hepatocellular differentiation of the pancreas have been reported in the literature. We report another case of hepatoid carcinoma of the pancreas that was associated with the development of a pancreatic endocrine carcinoma in a 46-year-old man. Serum alpha-fetoprotein (AFP) was elevated to 262.49 IU/mL and radiological examinations revealed a mass measuring 7.5 cm in diameter in the head of the pancreas. He underwent a conventional Whipple operation, and light microscopy showed adenocarcinoma that was immunopositive for AFP, hepatocyte antigen, cytokeratin, chromogranin, synaptophysin, and alpha-1 antichymotrypsin. Although hepatoid differentiation was not shown unequivocally histologically, other immunohistochemistry findings supported the diagnosis of hepatoid carcinoma combined with neuroendocrine carcinoma. The patient was healthy and had no evidence of recurrence at 4 months after the surgery. This report describes why hepatoid carcinoma should be considered as a differential diagnosis of a pancreatic mass, especially when serum AFP is elevated. (Gut Liver 2010;4:98-102)

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Hepatoid Carcinoma of the Pancreas Combined with Neuroendocrine Carcinoma

Jung

Kim

et al. 2010

Gut Liver

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“…7 Only a few cases have been reported and most also have areas with a more common direction of differentiation, particularly ductal adenocarcinoma. 7,[46][47][48][49][50] Medullary carcinoma is a malignant epithelial neoplasm characterized by poor differentiation, pushing borders, a syncytial growth pattern and necrosis ( Figure 12). 51,52 Most are microsatellite instable (MSI þ ), and immunolabeling will often reveal the loss of the expression of one of the DNA mismatch repair proteins, Mlh1 and Msh2.…”

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confidence: 99%

Pancreatic adenocarcinoma: update on the surgical pathology of carcinomas of ductal origin and PanINs

2007

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Pancreatic cancer is the fourth leading cause of cancer death in the US. Most pancreatic cancers are infiltrating ductal adenocarcinomas. The careful application of well-defined morphologic criteria can be used to differentiate between infiltrating ductal adenocarcinoma and reactive glands. While most pancreatic cancers are ductal adenocarcinomas, a number of histologically defined variants have been described. These are important to recognize because they have distinct clinical pathologic features. Pancreatic intraepithelial neoplasia (PanIN) is the presumed precursor lesion to infiltrating ductal adenocarcinoma, and PanIN lesions can mimic infiltrating cancer.

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“…(1,2) Exclusive hepatocytic differentiation is extremely rare. In the pancreas, hepatoid carcinomas are regarded as a heterogeneous group of tumors with or without another histological component, and carcinomas with pure hepatocytic features have been designated variously as hepatoid carcinoma or ectopic hepatocellular carcinoma.…”

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confidence: 99%

Hepatoid microcarcinoma of the pancreas: A case report and review of the literature

Huang¹,

Chang²,

Yeh³

et al. 2012

Biomed J

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Hepatoid differentiation in pancreatic carcinoma is a rare phenomenon. It occurs either as a pure form or as a component with other subtypes. Herein, we report a 52-year-old man with an ampullary large cell neuroendocrine carcinoma presenting with obstructive jaundice for 2 months. A 0.5-cm nodule was found in the pancreatic head. Morphologically, the nodule was composed of exclusively hepatocytic tumor cells and sinusoids with dysplastic cytology and capsular invasion. The patient did not have a hepatic mass or ectopic normal liver tissue. This is the first reported case of ampullary large cell neuroendocrine carcinoma coinciding with a pancreatic hepatoid microcarcinoma. The clinicopathological features of pancreatic hepatoid carcinomas and their histogenesis are discussed. (Chang Gung Med J 2012;35:285-91)

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Hepatoid carcinoma of the pancreas

Cited by 94 publications

References 11 publications

Hepatoid Carcinoma of the Pancreas Combined with Neuroendocrine Carcinoma

Hepatoid Carcinoma of the Pancreas Combined with Neuroendocrine Carcinoma

Pancreatic adenocarcinoma: update on the surgical pathology of carcinomas of ductal origin and PanINs

Hepatoid microcarcinoma of the pancreas: A case report and review of the literature

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