Hepatomas in Atlantic tomcod <i>Microgadus tomcod</i> (Walbaum) collected in the Hudson River estuary in New York

Smith, Charlie E.; Peck, Thomas H.; Klauda, Ronald J.; McLaren, J. B.

doi:10.1111/j.1365-2761.1979.tb00173.x

Cited by 95 publications

(26 citation statements)

References 4 publications

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“…In natural waters, it is difficult to isolate substances which alone are capable of inducing neoplasia formation. For the epizootics of hepatic neoplasias in the Baltic Sea (Falkmer et al 1977), Duwamish River (Washington, USA) (Pierce et al 1978), and the Hudson River estuary (New York, USA) (Smith et al 1979), PCBs (polychlorinated biphenyls) were the substances initially blamed for causing the disease. What seemed to be particularly strong evidence was provided by the case of the myxine hepatomas.…”

Section: Z Wmentioning

confidence: 99%

Liver anomalies in dab Limanda limanda from the southern North Sea with special consideration given to neoplastic lesions

Kranz¹,

Dethlefsen²

1990

Dis. Aquat. Org.

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Section: Z Wmentioning

confidence: 99%

Liver anomalies in dab Limanda limanda from the southern North Sea with special consideration given to neoplastic lesions

Kranz¹,

Dethlefsen²

1990

Dis. Aquat. Org.

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“…PAH have been implicated in the etiology of papillomas and epidermal carcinomas in bottom-dwelling freshwater brown bullheads Ictalurus nebulosus (Harshbarger 1981, Baumann et al 1982, Black 1983b, Baumann & Harshbarger 1985 and white suckers Catostomus con]-mersoni (Sonstegard 1977). PAH have also been implicated as the etiological agent of hepatic neoplasia in fish from highly polluted sites (Smith et al 1979. Malins et al 1987.…”

Section: Introductionmentioning

confidence: 99%

Epizootic papillomas in Prown bullheads Ictalurus nebulosus from Silver Stream reservoir, New York

Bowser¹,

Wolfe²,

Reimer³

et al. 1991

Dis. Aquat. Org.

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ABSTRACT. Fish from Silver Stream reservoir in Newburgh, New York (USA) were examined in 1985 and 1986 following reports by fishermen who had found a high prevalence of skin lesions in brown bullheads Ictalurus nebulosus caught in the reservoir Oral and skin papillomas were found in 43.2 % and 60.0 O/o of the brown bullheads from these respective samplings, whereas no papillomas were found in yellow bullheads I. natalis. No viral particles could be idenuied by electron microscopy in the lesions nor were cytopathic effects observed in primary cell cultures of tumor cells or from coculti\ration of these cells with an established brown bullhead cell line. Extracts of the sediment from the reservoir contained known promutagens but the concentrations of these compounds were low and similar to those found at reference sites considered to be non-contaminated. Nevertheless a positive response in the Ames assay of the extracts of the sediment was recorded. Elevated levels of chromium, copper, manganese, lead and vanadium were found in the sediments and copper, manganese, nickel, strontium and lead were elevated in the water. The pH of the interstitial water was 4.5. It is unlikely that any of these parameters was the sole causative factor in the etiology of the papillomas.

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“…These patterns are identical to those well known to occur in the liver neoplasms impaired by considerable anthropogenic input of various hepatotoxin, carcinogenic and/or carcinogenic promoters. [9][10][11][12][13][14][15][16] The time-course observation of the uptake and elimination of BHT showed that BHT was rapidly absorbed into the fish body through the digestive tract, distributed to various tissues by blood, taken to the liver, and then carried away to the alimentary tract with bile. The uptake pathway of BHT in Japanese eel was similar to those of nonylphenol ethoxylated, sodium linear alkylbenzene sulfonate and sodium alkylsulfate in fish.…”

Section: Resultsmentioning

confidence: 99%

Toxicity and Excretion of Butylated Hydroxytoluene (BHT) through Feed in Japanese Eel.

Hwang

Tsai

多摩夫³

et al. 1992

NIPPON SUISAN GAKKAISHI

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Attempts were made to elucidate sublethal responses of Japanese eel Anguilla japonica exposed to feed to which BHT had been added. The Japanese eel were administered BHT sublethal levels such as 0.02-1.6% BHT in their diet for 12 weeks. The symptoms of liver enlargement were commonly found in the fish group fed diet with BHT. However, this symptom would be alleviated when the fish were switched to the BHT-free diet. The pathological symptoms in hepatocyte induced by BHT were observed under microscope. The lesions indicated that the enlarged hepatocytes had hyperplasia, eosinophilia and, megalocytic hepatosis. The excretion of 14C-BHT in Japanese eel administered orally was also examined. The radioactivity was quickly distributed in the tissues at the beginning. The radioactivity was high in the bile of fish. 14C-BHT in the bile of fish increased with time, reached a maximum level at the 3rd day, and then decreased gradually.As previously described,1) butylated hydroxytoluene (BHT) has been widely used as an antioxidant for fish meal and feed in Taiwan.Judging from the ecotoxicological viewpoint, enlargement of the hepatopancreas was reported in common carp when they were fed a diet with supplemental BHT. The enlarged hepatopancreas had outstanding pathological symptoms of heavy steatosis, eosinophilia, and megalocytic hepatosis.1) Further, the level of BHT in common carp and rainbow trout was found to be high in the gall bladder and adipose tissue.2)In Taiwan, Japanese eel Anguilla japonica is a popular species of aquaculture and its artificial feed is mainly made from fish meal. The Japanese eel belongs to a species of high lipid content. To compare with common carp, the responses of Japanese eel to BHT are studied after oral administration of BHT through feed. Further, the physiological disposition of BHT in Japanese eel was also studied by using a labelled compound, 14C-BHT. Materials and MethodsFive hundred specimens of Japanese eel were obtained from Fwu Sow Marine Products Co. LTD., R. O. C. The fish were acclimated in several

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Hepatomas in Atlantic tomcod Microgadus tomcod (Walbaum) collected in the Hudson River estuary in New York

Cited by 95 publications

References 4 publications

Liver anomalies in dab Limanda limanda from the southern North Sea with special consideration given to neoplastic lesions

Liver anomalies in dab Limanda limanda from the southern North Sea with special consideration given to neoplastic lesions

Epizootic papillomas in Prown bullheads Ictalurus nebulosus from Silver Stream reservoir, New York

Toxicity and Excretion of Butylated Hydroxytoluene (BHT) through Feed in Japanese Eel.

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