Hepatopancreatic amylase activity as a function of warm-adaptation in a fresh-water field crab

Krishnamoorthy, R. V.; Reddy, V Venkata

doi:10.1007/bf02138720

Cited by 6 publications

(3 citation statements)

References 10 publications

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“…The values of neutrophil, platelet and lymphocyte, monocyte, LDH and ALP values can be easily obtained with minimally invasive procedures. Recently, these markers have been evaluated in many studies to predict the prognosis in patients with various types of cancer including hepatocellular carcinoma, renal cell carcinoma, lung cancer, urinary cancer and colorectal cancer 36–41. These markers such as NLR, PLR and MLR are believed to reflect the interplay between the systemic inflammatory responses with the tumor microenvironment.…”

Section: Discussionmentioning

confidence: 99%

<p>The prognostic value of pretreatment inflammatory biomarkers in primary angiosarcoma</p>

Wang¹,

Wu²,

An³

et al. 2019

CMAR

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BackgroundRecent studies have suggested a significant relationship between inflammatory indexes such as the neutrophil-to-lymphocyte ratio (NLR) and survival outcomes in various cancers. The aim of the present study was to evaluate the prognostic value of 6 pretreatment inflammatory markers in patients with primary angiosarcoma (AS) which is a rare and highly malignant type of soft tissue sarcoma.MethodsFifty-six patients diagnosed with primary AS at West China Hospital between August 2009 and July 2016 were retrospectively enrolled. The value of each biomarker was calculated for its correlation with patients’ overall survival.ResultsThe low tumor grade, tumor size <5 cm, metastatic status, surgical treatment and low level of monocyte-to-lymphocyte ratio, NLR and lactate dehydrogenase (LDH) were correlated with better survival outcome in univariate analyses. In multivariate analyses, high levels of NLR (HR 2.673, 95% CI 1.253–5.703, p=0.011) and LDH (HR 2.964, 95% CI 1.464–5.998, p=0.003) were selected as independent prognostic factors.ConclusionThis study identifies the elevated pretreatment levels of NLR and LDH as prognostic markers in patients with primary AS.

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Section: Discussionmentioning

confidence: 99%

<p>The prognostic value of pretreatment inflammatory biomarkers in primary angiosarcoma</p>

Wang¹,

Wu²,

An³

et al. 2019

CMAR

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“…Inflammatory biomarkers, such as white blood cell counts and acute phase proteins, have repeatedly been shown to have prognostic value [19]. Prognostic markers of systemic inflammation, such as d-NLR, NLR and LMR, are associated with disease outcomes in a variety of tumors, and are readily available and inexpensive [20][21][22][23][24][25][26][27]. In our study, the variables of prognostic value were ALB, PLT and LDH, as independent indicators for sporadic BL.…”

Section: Discussionmentioning

confidence: 61%

A novel prognostic index for sporadic Burkitt lymphoma in adult patients: a real-word multicenter study

et al. 2022

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Background Adult sporadic Burkitt lymphoma (BL) is a rare but highly aggressive subtype of lymphoma which lacks its own unique prognostic model. Systemic inflammatory biomarkers have been confirmed as prognostic markers in several types of malignancy. Our objective was to explore the predictive value of pretreatment inflammatory biomarkers and establish a novel, clinically applicable prognostic index for adult patients with sporadic BL. Methods We surveyed retrospectively 336 adult patients with newly diagnosed sporadic BL at 8 Chinese medical centers and divided into training cohort (n = 229) and validation cohort (n = 107). The pretreatment inflammatory biomarkers were calculated for optimal cut-off value. The association between serum biomarkers and overall survival (OS) was analyzed by Kaplan–Meier curves and Cox proportional models. The risk stratification was defined based on normal LDH level, Ann Arbor stage of I and completely resected abdominal lesion or single extra-abdominal mass < 10 cm. Results and conclusions Univariate and multivariate analyses revealed that platelets< 254 × 109/L, albumin< 40 g/L, lactate dehydrogenase≥334 U/L independently predicted unfavorable OS. We used these data as the basis for the prognostic index, in which patients were stratified into Group 1 (no or one risk factor), Group 2 (two risk factors), or Group 3 (three risk factors), which were associated with 5-year OS rates of 88.1, 72.4, and 45%, respectively. In the subgroup analysis for high-risk patients, our prognostic model results showed that high-risk patients with no more than one adverse factor presented a 5-year survival rate of 85.9%, but patients with three adverse factors had a 5-year survival rate of 43.0%. Harrell’s concordance index (C-index) of the risk group score was 0.768. Therefore, the new prognostic model could be used to develop risk-adapted treatment approaches for adult sporadic BL.

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“…In ammatory biomarkers, such as white blood cell counts and acute phase proteins, have repeatedly been shown to have prognostic value (20). Prognostic markers of systemic in ammation, such as d-NLR, NLR and LMR, are associated with disease outcomes in a variety of tumors, and are readily available and inexpensive (21)(22)(23)(24)(25)(26)(27)(28). In our study, the variables of prognostic value were ALB, PLT and LDH, as independent indicators for sporadic BL.…”

Section: Discussionmentioning

confidence: 99%

A Novel Prognostic Index for Sporadic Burkitt Lymphoma in Adult Patients: A Real-Word Multicenter Study

Chen

Fang

Zhang

et al. 2021

Preprint

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Background: Adult sporadic Burkitt lymphoma (BL) is a rare but highly aggressive subtype of lymphoma which lacks its own unique prognostic model. Systemic inflammatory biomarkers have been confirmed as prognostic markers in several types of malignancy. Our objective was to explore the predictive value of pretreatment inflammatory biomarkers and establish a novel, clinically applicable prognostic index for adult patients with sporadic BL. Methods: We surveyed retrospectively 336 adult patients with newly diagnosed sporadic BL at 8 Chinese medical centers and divided into training cohort (n=229) and validation cohort (n=107). The pretreatment inflammatory biomarkers were calculated for optimal cut-off value. The association between serum biomarkers and overall survival (OS) was analyzed by Kaplan–Meier curves and Cox proportional models.Results and Conclusions: Univariate and multivariate analyses revealed that platelets<254×109/L, albumin<40g/L, lactate dehydrogenase≥334U/L independently predicted unfavorable OS. We used these data as the basis for the prognostic index, in which patients were stratified into Group 1 (no or one risk factor), Group 2 (two risk factors), or Group 3 (three risk factors), which were associated with 5-year OS rates of 88.1%, 72.4%, and 45%, respectively. In the subgroup analysis for high-risk patients, our prognostic model results showed that high-risk patients with no more than one adverse factor presented a 5-year survival rate of 85.9%, but patients with three adverse factors had a 5-year survival rate of 43.0%. Harrell’s concordance index (C-index) of the risk group score was 0.768. Therefore, the new prognostic model could be used to develop risk-adapted treatment approaches for adult sporadic BL.

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Hepatopancreatic amylase activity as a function of warm-adaptation in a fresh-water field crab

Cited by 6 publications

References 10 publications

<p>The prognostic value of pretreatment inflammatory biomarkers in primary angiosarcoma</p>

<p>The prognostic value of pretreatment inflammatory biomarkers in primary angiosarcoma</p>

A novel prognostic index for sporadic Burkitt lymphoma in adult patients: a real-word multicenter study

A Novel Prognostic Index for Sporadic Burkitt Lymphoma in Adult Patients: A Real-Word Multicenter Study

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