Hepatopreventive properties of hydroxytyrosol and mannitol-rich extracts obtained from exhausted olive pomace using green extraction methods

Contreras, María del Mar; Gómez‐Cruz, Irene; Feriani, Anouar; Alwasel, Saleh; Harrath, Abdel Halim; Romero, Inmaculada; Castro, Eulógio; Tlili, Nizar

doi:10.1039/d2fo00888b

Cited by 6 publications

(8 citation statements)

References 69 publications

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“…Besides the antioxidant capacity of olive phenolic compounds in biological and food systems [84,85], olive phenolic compounds present a wide range of pharmacological properties, as reviewed in [12,86]. As an example, Tab.…”

Section: Phenolic Compoundsmentioning

confidence: 99%

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Towards the Integral Valorization of Olive Pomace‐Derived Biomasses through Biorefinery Strategies

Gómez‐Cruz,

del Mar Contreras,

Romero

et al. 2024

ChemBioEng Reviews

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The olive oil sector generates a high quantity of biomasses every year, especially in the Mediterranean region. Olive pomace is the main one, but depending on the extraction and subsequent processing, other derived biomass by‐products are generated like pâté, exhausted olive pomace, olive stone, and residual pulp. Their sustainable valorization is crucial. Therefore, this review first conceptualizes the current situation of the olive oil sector and describes these biomasses from a qualitative and quantitative point of view. Second, information on the bioactive compounds they present, the technologies used for their extraction, and examples of applications for their extracts is provided. Third, since the extraction of bioactive compounds will generate new residual biomasses, this review takes a step forward by integrating the extraction step in biorefinery cascading schemes. It also analyzes the benefits of this integration, the contribution to a circular (bio)economy, and the achievement of sustainable development goals.

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Section: Phenolic Compoundsmentioning

confidence: 99%

“…The extraction will reduce the complexity of the original biomass, concentrating the compounds of interest. At the same time, the solid fraction will be enriched in non-nutritive components such as lignin, cellulose, and hemicellulose [85]. Tab.…”

Section: Examples Of Industrial Applications Of Olive Bioactive Compo...mentioning

confidence: 99%

Towards the Integral Valorization of Olive Pomace‐Derived Biomasses through Biorefinery Strategies

Gómez‐Cruz,

del Mar Contreras,

Romero

et al. 2024

ChemBioEng Reviews

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“…The phenolic profiles were acquired using two methodologies, one using high-performance liquid chromatography (HPLC) and UV detection and the other based on HPLC-quadrupole time-of-flight (QTOF)-mass spectrometry (MS), according to a previous study [15]. The former analysis was performed in a Prominence UFLC chromatograph (Shimadzu Corporation, Kyoto, Japan) using a BDS HYPERSIL column (C18 with 5 µm particle size; dimensions, 4.6 mm × 250 mm) (Thermo Fisher Scientific Inc., Waltham, MA, USA).…”

Section: Phenolic Content Composition and Antioxidant Assaysmentioning

confidence: 99%

“…The former analysis was performed in a Prominence UFLC chromatograph (Shimadzu Corporation, Kyoto, Japan) using a BDS HYPERSIL column (C18 with 5 µm particle size; dimensions, 4.6 mm × 250 mm) (Thermo Fisher Scientific Inc., Waltham, MA, USA). The gradient conditions and mobile phases were in accordance with previous studies [14,15]. The commercial standards of trans-resveratrol and trans-ε-viniferin were obtained from Extrasynthese (Genay, France) and used for quantification in the aforementioned chromatographic conditions at 280 nm.…”

Section: Phenolic Content Composition and Antioxidant Assaysmentioning

confidence: 99%

Grapevine Shoot Extract Rich in Trans-Resveratrol and Trans-ε-Viniferin: Evaluation of Their Potential Use for Cardiac Health

Contreras,

Feriani,

Gómez-Cruz

et al. 2023

Foods

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A grapevine shoot extract (GSE) was obtained using ultrasound-assisted extraction and characterized. The main phenolic constituents were identified as stilbenoids. Among them, trans-resveratrol and trans-ε-viniferin stood out. The GSE was administered to an isoproterenol-induced myocardial injury animal model. The extract alleviated the associated symptoms of the administration of the drug, i.e., the plasma lipid profile was improved, while the disturbed plasma ion concentration, the cardiac dysfunction markers, the DNA laddering, and the necrosis of myocardial tissue were diminished. This effect could be related to the anti-oxidative potential of GSE associated with its antioxidant properties, the increased levels of endogenous antioxidants (glutathione and enzymatic antioxidants), and the diminished lipid peroxidative markers in the heart. The results also revealed angiotensin-converting enzyme (ACE)-inhibitory activity, which indicated the potential of GSE to deal with cardiovascular disease events. This work suggests that not only trans-resveratrol has a protective role in heart function but also GSE containing this biomolecule and derivatives. Therefore, GSE has the potential to be utilized in the creation of innovative functional ingredients.

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“…HT shows anti-fibrotic and anti-inflammatory effects by regulating oxidative stress in the liver (24). HT has also been shown to have a protective effect against liver damage (25). Another study has shown a combined HT and Vitamin E application to reduce fibrosis associated with non-alcoholic fatty liver disease (26).…”

Section: Introductionmentioning

confidence: 99%

Effect of Hydroxytyrosol on Prdx6 Expression in Diabetic Rat Liver

ALMALI,

KARACOR,

SOYLU

2023

Düzce Tıp Fakültesi Dergisi

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Aim: Oxidative stress caused by hyperglycemia, which is the most important complication of diabetes mellitus, causes liver damage. Hydroxytyrosol is a polyphenolic compound abundant in olive oil that protects the liver against oxidative damage. Peroxiredoxin 6 (Prdx6) is an anti-oxidative enzyme known to exist in the liver. The aim of this study was to investigate the effect of hydroxytyrosol on Prdx6 expression in diabetes-induced liver injury. Material and Methods: Male Wistar rats were grouped into four as the control group (n=10), hydroxytyrosol group (n=10), streptozotocin group (n=10), and hydroxytyrosol+streptozotocin group (n=10). Blood glucose levels of the animals were measured after streptozotocin injection and at the end of the experiment. The general structure of the liver was examined with a hematoxylin-eosin stain. Prdx6 protein expression was determined with an immunohistochemical method. Results: In the streptozotocin+hydroxytyrosol group, blood glucose level was found to be lower when compared with the streptozotocin group (p

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Hepatopreventive properties of hydroxytyrosol and mannitol-rich extracts obtained from exhausted olive pomace using green extraction methods

Abstract: Exhausted olive pomace (EOP) is produced in the olive-pomace oil extractors as by-product. However, the obtention of bioactive compounds from EOP can reinsert it into the economy as a new...

Cited by 6 publications

References 69 publications

Towards the Integral Valorization of Olive Pomace‐Derived Biomasses through Biorefinery Strategies

Towards the Integral Valorization of Olive Pomace‐Derived Biomasses through Biorefinery Strategies

Grapevine Shoot Extract Rich in Trans-Resveratrol and Trans-ε-Viniferin: Evaluation of Their Potential Use for Cardiac Health

Effect of Hydroxytyrosol on Prdx6 Expression in Diabetic Rat Liver

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