Hepatoprotective activity of 1,2,4-triazole-3-thione derivatives, which contains on C5 atomic carbon hydroxy(phenyl)methyl dependent

Rud, A. M.; Kaplaushenko, A. G.; Pruglo, Ye. S.; Sameliuk, Yu. G.; Frolova, Yu. S.

doi:10.24959/ubphj.18.178

Cited by 4 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Safety, tolerance to the drug, possibility of continuous intake, economical reasoning are the deciding factors in favour of choosing certain hepatoprotective remedies. The widening of hepatoprotectors' variety, caused by implementing new discoveries in biochemistry, molecular biology and nanotechnology, is on agenda for modern scientists [2,3]. Many 1,3,4-oxadiazole, 1,2,4-triazole and 1,3,4-thiadiazole derivatives are of great interest and are associated with a broad spectrum of pharmacological activities [4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Histological Study of a Corrective Influence of a Compound Potassium 2-((4-Amino-5-(Morpholinomethyl)- 4h-1,2,4-Triazol-3-Yl)thio)acetate (Pkr-173) on the State of Chicken's Liver Under Infection by Pseudomonas Aeruginosa

Vashchyk¹,

Shcherbyna²,

Парченко³

et al. 2020

Ankara Universitesi Eczacilik Fakultesi Dergisi

View full text Add to dashboard Cite

Objective: The aim of the research is the histological study of the corrective effect of the compound potassium 2((4-amino-5-(morpholinomethyl)-4H-1,2,4-triazol-3yl)thio)acetate (PKR-173) with different antibiotics on the state of chicken's liver under infection by Pseudomonas aeruginosa. Material and Method: The histological study was carried out on the levers of intact chickens (intact control); chickens that were infected by the strain of Pseudomonas aeruginosa (controlled pathology); chickens that had (before being infected by Pseudomonas aeruginosa

show abstract

Section: Introductionmentioning

confidence: 99%

Histological Study of a Corrective Influence of a Compound Potassium 2-((4-Amino-5-(Morpholinomethyl)- 4h-1,2,4-Triazol-3-Yl)thio)acetate (Pkr-173) on the State of Chicken's Liver Under Infection by Pseudomonas Aeruginosa

Vashchyk¹,

Shcherbyna²,

Парченко³

et al. 2020

Ankara Universitesi Eczacilik Fakultesi Dergisi

View full text Add to dashboard Cite

show abstract

“…Separately to the ability to proliferate, 1,2,4-triazole derivatives are able to have a cytoprotective effect. Cytoprotection is manifested in antioxidant [41][42][43][44][45], antihypoxic [46][47][48][49][50], hepatoprotective [51][52][53][54][55], neuroprotective [56][57][58][59][60] action. In particular, scientists [60] conducted an extensive review of 64 compounds that can find their application in the treatment of Alzheimer's disease.…”

Section: Cytoprotective Activity Of 124-triazolesmentioning

confidence: 99%

“…7). In the analyzed works [41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60], 40 potential antioxidants were identified, among which the authors separately Note 4 molecules; 44 compounds with antihypoxic activity were identified, of which 5 are recommended for further study. 106 potential neuroprotectors were identified, of which 7 attract special attention of scientists.…”

Section: Cytoprotective Activity Of 124-triazolesmentioning

confidence: 99%

Prospects for the search for new biologically active compounds among the derivatives of the heterocyclic system of 1,2,4-triazole.

et al. 2022

View full text Add to dashboard Cite

The authors are not native speakers of Turkish The purpose of this literature review was to systematize data from studies of the biological activity of 1,2,4-triazole derivatives with substituents in positions 4 and 5. The authors set the task of forming an idea of current directions in the selection of substitutions for 1,2,4-triazole based on research. As a result of the study, 75 literature sources were analyzed. This made it possible to form a further vector in terms of searching for biologically active structures among 1,2,4-triazole derivatives. The review develops a modern approach to the search for biologically active substances among 1,2,4-triazole derivatives. Systematized data on the nature of substituents in the core of 1,2,4-triazole, which affect a specific type of activity. The search material was selected over the past decade with the highest number of citations at the time of literature analysis.

show abstract

“…Worldwide, in 2015, approximately 257 million people lived with chronic hepatitis B virus (HBV) infection and 71 million people with chronic hepatitis C virus (HCV) infection 1. Therefore, this problem is very topical and it is sharply stands before medicine and pharmacy in general [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

The Research of 1,2,4-Triazole Derivatives Hepatoprotective Activity Under Tetracycline and Infectious Hepatitis

Shcherbyna¹,

Vashchyk²

2019

Ankara Universitesi Eczacilik Fakultesi Dergisi

View full text Add to dashboard Cite

Objective: The purpose of this work is to study the hepatoprotective properties of potassium 2-((4-amino-5-(morpholinomethyl)-4H-1,2,4-triazole-3-yl)thio)acetate on tetracycline and infectious hepatitis models in chickens. Material and Method: Biochemical examination of blood and liver serum was carried out on intact broiler chickens Cross Cobb 500. All groups of chickens were kept separately in different cages in the same room with the same microclimate parameters in accordance with the established requirements. Result and Discussion: Hepatoprotective effect of potassium 2-((4-amino-5-(morpholinomethyl)-4H-1,2,4-triazole-3-yl)thio)acetate was established as a result of research on the model of hepatitis in chickens caused by tetracycline, which was not lower than the referent drug-Thiotriazolin ®. The biochemical study results demonstrated hepatoprotective properties of the combination of the above compound with the antibiotic Saroflox ® , combination of potassium 2-((4-amino-5-(morpholinomethyl)-4H-1,2,4-triazole-3-yl) thio) acetate with classical antibiotic Enrofloxacin ® on the model of infectious hepatitis.

show abstract

Hepatoprotective activity of 1,2,4-triazole-3-thione derivatives, which contains on C5 atomic carbon hydroxy(phenyl)methyl dependent

Cited by 4 publications

References 0 publications

Histological Study of a Corrective Influence of a Compound Potassium 2-((4-Amino-5-(Morpholinomethyl)- 4h-1,2,4-Triazol-3-Yl)thio)acetate (Pkr-173) on the State of Chicken's Liver Under Infection by Pseudomonas Aeruginosa

Histological Study of a Corrective Influence of a Compound Potassium 2-((4-Amino-5-(Morpholinomethyl)- 4h-1,2,4-Triazol-3-Yl)thio)acetate (Pkr-173) on the State of Chicken's Liver Under Infection by Pseudomonas Aeruginosa

Prospects for the search for new biologically active compounds among the derivatives of the heterocyclic system of 1,2,4-triazole.

The Research of 1,2,4-Triazole Derivatives Hepatoprotective Activity Under Tetracycline and Infectious Hepatitis

Contact Info

Product

Resources

About