Hepatoprotective Activity of Aqueous Ethanolic Extract of Chamomile capitula in Paracetamol Intoxicated Albino Rats

Abstract

Hepatoprotective activity of aqueous ethanolic extract of Chamomile recutita capitula against paracetamol induced hepatic damage in albino rats was observed. In the present study the effect of aqueous ethanolic extract of Chamomile recutita capitula on blood and liver glutathione, Na + K + -ATPase activity, serum marker enzymes, serum bilirubin, glycogen and thiobarbutiric acid reactive substances against paracetamol induced damage in rats have been studied to find out the possible mechanism of hepatoprotection. It was observed that extract of chamomile has reversal effects on the levels of above-mentioned parameters in paracetamol hepatotoxicity. The extract of capitula of chamomile functions as a hepatoprotective agent and this hepatoprotective activity of chamomile may be due normalization of impaired membrane function activity.

Identification of the Therapeutic Effects of Gamma-Irradiated Chamomile Aqueous Extract Against Alcohol Induced Hepato-nephrotoxicity in Rats

“…This was associated, however, with a remarkable elevation of total proteins, albumin, and globulin levels of the group of rats that received ethanol alone. These results agreed with those of Gupta and Misra (2006) who concluded that chamomile extract functions as a hepatoprotective agent cause a reduction of the elevated serum levels of ALT and AST and this activity may be due to normalization of impaired membrane function activity. Najla et al (2012) studied the effect of hypoglycemic of chamomile leave extract and observed that the activity of AST, ALT and ALP and the values of urea, creatinine and uric acid were reduced after chamomile treatment in diabetic rats.…”

The histological effects of Moringa extract on mercury induced hepatotoxicity in adult wistar rats

“…Liver protective herbal drugs contain a variety of chemical constituents like phenols, coumarins, lignans, essential oil, monoterpenes, caro tinoids, glycosides, flavonoids, organic acids, lipids, alkaloids and xanthenes 6,7 , this may be present in the Moringa oleifera and so responsible for this effect.…”

In Vitro Evaluation of Antioxidant Potential and in Vivo Studies for Preclinical Toxicity With Hepatoprotective Activity of Safoof-E-Akseer-E-Jigar

“…The hepatotoxicity in these animals was induced by Paracetamol. [20,21,22,23,24,25,26] The rats were divided into four groups each consist of six rats. [14,15,18,19,27] The control group was given only sterile normal saline.…”