Hepatoprotective activity of Eclipta alba against carbon tetrachloride-induced hepatotoxicity in albino rats

Beedimani, Ravindra S.; Shetkar, Shivkumar

doi:10.18203/2319-2003.ijbcp20150045

Cited by 4 publications

(2 citation statements)

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“…Pre- and post-treatment with 80% methanol extract at the dose of 600mg/kg largely modulated the severity of CCl4. In line with this, another Hepatoprotective study of the plant Eclipta alba against carbon tetrachloride-induced hepatotoxicity in albino rats showed that in the CCl4 administered Group: ALT, AST, ALP, total serum bilirubin were increased significantly whereas, administration of aqueous extract of E. alba at a dose of 250 mg/kg body weight showed statistically significant improvement in the serum ALT, AST, ALP, total serum bilirubin levels (44)…”

Section: Discussionmentioning

confidence: 68%

Phytochemical Screening, Investigation of the toxic and hepatoprotective effect of leaves ofPrunus africana-using mice model

Dabe,

Kefale,

Addo

et al. 2024

Preprint

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Purpose: Liver disease is a growing public health problem both in developing and developed countries. Allopathic medicines available for liver disease are not accessible and affordable for 3rd world countries, like Ethiopia. There is a need to search for alternative therapy, in which herbals are widely used in traditional medicine and promising for the development of effective and less costly treatment. As a result, this study aimed to screen phytochemicals and investigate the toxic and hepatoprotective effects of Prunus africana which is traditionally used in Benchi sheko and Sheka Zones, Southwest Ethiopia. Methods: Methanolic extracts of Prunus africana, were used to evaluate the toxicity and hepatoprotective activity in both male and female swiss Albino Mice. Liver injury was induced by carbon tetrachloride (CCl4). The toxicity and hepatoprotective activity were examined biochemically, histologically, and through the analysis of the general features of the study animals. The phytochemical composition was screened qualitatively using standard chemical tests for secondary metabolites. The results were expressed as Mean ± SD, and differences at P < 0.05 were considered significant. Differences between the experimental and control groups were analyzed using one-way analysis of variance (ANOVA) followed by Dunnett's T-test to determine their level of significance. Results: The extract of Prunus africana revealed positive for the presence of flavonoids and Saponins but negative for Anthraquinone glycoside. The current study showed that the median oral lethal dose of the plant was greater than 5000mg/kg. The general behavior of the animal and organ weight, gross morphology, and the biochemical and histological parameters confirmed that the Methanolic leaves extract of this plant is safe during the sub-acute toxicity tests with a dose of 600 and 1800mg/kg. Methanolic extract before and after the CCl4 administration caused a significant reduction in the values of Alanine transaminase, Aspartate transaminase, Alkaline phosphatase, and bilirubin (P<0.05) almost comparable to the standard drug Silymarine. The hepatoprotective activity was supported by histopathological examination of the liver tissue of control and treated animals. Conclusion: The methanolic extract of Prunus africana at the test doses did not show significant toxicity. The results of this study also demonstrate that the extract was effective for the prevention of CCl4-induced hepatic damage in Mice. This study thus justifies that, the use of Prunus africana in the treatment of liver diseases and points out that this plant warrants further detailed investigation as a promising hepatoprotective agent.

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Section: Discussionmentioning

confidence: 68%

Phytochemical Screening, Investigation of the toxic and hepatoprotective effect of leaves ofPrunus africana-using mice model

Dabe,

Kefale,

Addo

et al. 2024

Preprint

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“…T. cordifolia (leaf, stem and root), Momordica charantia L. (fruit), M. arvensis (leaves), Lawsonia inermis L. (leaves), E. officinalis, Eclipta alba (L.) Hassk. (leaves), Clitoria ternatea L. (leaves), Cassia angustifolia M. Vahl (leaves), Argemone mexicana L. (leaves), Abrus precatorius L. (seeds) normalized elevated levels of AST, ALT, ALP and bilirubin in vivo (Battu and Kumar, 2009; Beedimani and shetkar, 2015 ; Bhuvaneswari et al, 2014 ; Kavitha and Geetha, 2018 ; Kowti et al, 2013 ; Mohamed et al, 2017 ; Nithianantham et al, 2011 ; Shanmugasundaram et al, 2010 ; Sourabie et al, 2012; Zahra et al, 2012 ). The fruits of Solanum xanthocarpum Schrad.…”

Section: Role Of Natural Products In the Management Of Post-covid Complicationsmentioning

confidence: 99%

Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications

et al. 2022

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Background : The worldwide corona virus disease outbreak, generally known as COVID-19 pandemic outbreak resulted in a major health crisis globally. The morbidity and transmission modality of COVID-19 appear more severe and uncontrollable. The respiratory failure and following cardiovascular complications are the main pathophysiology of this deadly disease. Several therapeutic strategies are put forward for the development of safe and effective treatment against SARS-CoV-2 virus from the pharmacological view point but till date there are no specific treatment regimen developed for this viral infection. Purpose : The present review emphasizes the role of herbs and herbs-derived secondary metabolites in inhibiting SARS-CoV-2 virus and also for the management of post-COVID-19 related complications. This approach will foster and ensure the safeguards of using medicinal plant resources to support the healthcare system. Plant-derived phytochemicals have already been reported to prevent the viral infection and to overcome the post-COVID complications like parkinsonism, kidney and heart failure, liver and lungs injury and mental problems. In this review, we explored mechanistic approaches of herbal medicines and their phytocomponenets as antiviral and post-COVID complications by modulating the immunological and inflammatory states. Study design : Studies related to diagnosis and treatment guidelines issued for COVID-19 by different traditional system of medicine were included. The information was gathered from pharmacological or non-pharmacological interventions approaches. The gathered information sorted based on therapeutic application of herbs and their components against SARSCoV-2 and COVID-19 related complications. Methods : A systemic search of published literature was conducted from 2003 to 2021 using different literature database like Google Scholar, PubMed, Science Direct, Scopus and Web of Science to emphasize relevant articles on medicinal plants against SARS-CoV-2 viral infection and Post-COVID related complications. Results : Collected published literature from 2003 onwards yielded with total 625 articles, from more than 18 countries. Among these 625 articles, more than 95 medicinal plants and 25 active phytomolecules belong to 48 plant families. Reports on the therapeutic activity of the medicinal plants belong to the Lamiaceae family (11 reports), which was found to be maximum reported from 4 different countries including India, China, Australia, and Morocco. Other reports on the medicinal plant of Asteraceae (7 reports), Fabaceae (8 reports), Piperaceae (3 reports), Zingiberaceae (3 reports), Ranunculaceae (3 reports), Meliaceae (4 reports) were found, which can be explored for the development of safe and efficacious products targeting COVID-19. Conclusion : K...

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Plants used for the treatment of icterus (jaundice) in Central India: A review

Janghel¹,

Patel²,

Chandel³

2019

Annals of Hepatology

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Hepatoprotective activity of Eclipta alba against carbon tetrachloride-induced hepatotoxicity in albino rats

Cited by 4 publications

References 11 publications

Phytochemical Screening, Investigation of the toxic and hepatoprotective effect of leaves ofPrunus africana-using mice model

Phytochemical Screening, Investigation of the toxic and hepatoprotective effect of leaves ofPrunus africana-using mice model

Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications

Plants used for the treatment of icterus (jaundice) in Central India: A review

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