Hepatoprotective activity of ethanolic and aqueous extract of Turnera aphrodisiaca leaves against CCl4-induced liver injury in rats

Bathula, Naveen Kumar; Choudhary, Bimalendu

doi:10.18203/2319-2003.ijbcp20193174

Cited by 2 publications

(2 citation statements)

References 25 publications

(25 reference statements)

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“…At the end of the study, they found a significant reduction in ALT, AST, and ALP levels in the groups treated with the extracts compared with the untreated groups. In contrast, SOD and CAT activity significantly increased [28]. Similar results were obtained with the ethanolic extract by employing an ethanol damage model and increasing the treatment period to 21 days, in addition to decreasing total bilirubin levels.…”

Section: Hepatoprotectionsupporting

confidence: 79%

“…Table 5 includes mostly studies whose main objective was not to evaluate antioxidant activity. However, these studies show the ability of the extracts to modulate the activity of antioxidant enzymes [28], in addition to decreasing the levels of lipid peroxidation and cell damage caused by the generation of free radicals and reactive oxygen species [27,30]. Therefore, Tables 1-5 may include results not discussed in this section but will be addressed later.…”

Section: Introductionmentioning

confidence: 99%

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Bioactivity of the Genus Turnera: A Review of the Last 10 Years

Parra-Naranjo,

Delgado-Montemayor,

Salazar-Aranda

et al. 2023

Pharmaceuticals

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Turnera is a genus of plants whose biological activity has been widely studied. The importance of this genus, particularly Turnera diffusa, as a source of treatment for various conditions is evidenced by the large number of new studies that have evaluated its biological activity. Accordingly, the objective of this review was to compile the information published in the last ten years concerning the biological activities reported for Turnera spp. The present work includes 92 publications that evaluate 29 bioactivities and toxicological and genotoxic information on five species of this genus. Among the pharmacological effects reported, the antioxidant, hepatoprotective, neuroprotective, hypoglycemic, and aphrodisiac activities seem more promising. Phytochemicals and standardized plant extracts could offer alternative therapeutic remedies for various diseases. Although several flavonoids, cyanogenic glycosides, monoterpenoids, triterpenoids, and fatty acids have been isolated for Turnera plants, future research should focus on the identification of the main active principles responsible for these pharmacological activities, as well as to perform clinical trials to support the laboratory results.

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Section: Hepatoprotectionsupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Bioactivity of the Genus Turnera: A Review of the Last 10 Years

Parra-Naranjo,

Delgado-Montemayor,

Salazar-Aranda

et al. 2023

Pharmaceuticals

View full text Add to dashboard Cite

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Seasonal variation, treatment outcome, and its associated factors among the snakebite patients in Somali region, Ethiopia

Ahmed

Yusuf

Debella

et al. 2022

Front. Public Health

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BackgroundSnakebite is a major cause of mortality and morbidity in many areas, particularly in the rural tropics, and is a major public health problem around the world. It also imposes significant economic burdens on snakebite victims due to treatment-related expenses and lost productivity.ObjectiveThe purpose of this study was to assess seasonal variation, treatment outcomes, and its associated factors among snakebite in Denan health center in the Somali region, Ethiopia.MethodA facility-based cross-sectional study was conducted from 10 to 30 September 2020 in Denan health center, Somali region, Ethiopia. All snakebite cases in Denan health center from 1 September 2015 to 31 August 2020 were included. Data were collected using a pre-tested structured checklist from the patient cards. Data were entered into EpiData version 3.1 and analyzed using SPSS version 22 (IBM SPSS Statistics, 2013). The prevalence was reported by proportion with 95% confidence interval (CI) and summary measures. Predictors were assessed using a multivariable logistic regression analysis model and reported using an adjusted odds ratio with 95% CI. Statistical significance was declared at p-value < 0. 05.ResultThe overall prevalence of poor outcome of venomous snakebites was 31.4% (95% CI 26.3% 35.4%). Study participants with an age of less than 10 years old (AOR = 2.01; 95% CI 1.39, 4.05), age between 10 and 30 years old (AOR = 2.06; 95% CI 1.39, 9.30), arrival times greater than or equal to 6 hours (AOR = 2.37; 95% CI 1.39, 4.05), and timing of snakebite (AOR = 0.49; 95% CI 0.31–0.87) were factors found to be significantly associated with poor treatment outcome.ConclusionAccording to this study, about one in every three snakebite patients have a poor outcome. Patients with poor outcomes were those who did not improve as a result of treatment or died as a result of it. Designing appropriate engagement of public health education about snakebite prevention techniques, particularly during entry and exit of rainy seasons and establishment of appropriate case management protocol is strongly recommended, as well as increasing the accessibility or availability of antivenoms will undoubtedly have a significant impact on the reduction of mortality and disability related to that of the snakebites.

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Hepatoprotective activity of ethanolic and aqueous extract of Turnera aphrodisiaca leaves against CCl4-induced liver injury in rats

Cited by 2 publications

References 25 publications

Bioactivity of the Genus Turnera: A Review of the Last 10 Years

Bioactivity of the Genus Turnera: A Review of the Last 10 Years

Seasonal variation, treatment outcome, and its associated factors among the snakebite patients in Somali region, Ethiopia

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