Hepatoprotective activity of Flacourtia jangomas (Lour.) Raeuschleaves and fruit methanolic extract on paracetamol-induced hepatotoxicity in HepG2 Cells

Pai, Akshaya; Shenoy, Chandrakala

doi:10.51248/.v41i3.1197

Cited by 2 publications

(2 citation statements)

References 7 publications

(9 reference statements)

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“…But, in this study the dose they have used is too high and it is not successful or rationale for human dose. 71…”

Section: Flacourtia Indicamentioning

confidence: 99%

Roles of Herbals in Paracetamol Induced Hepatotoxicty

Devi,

Verma,

Kumar

2023

J. Drug Delivery Ther.

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In the area of herbal medicine, this has led to a great deal of research and development. In the majority of industrialized and developing nations today, there is a rising need for herbal medicine. The most common form of liver disease varies by country and may be impacted by local factors. Infection with viruses and exposure to specific chemicals are two causes of liver diseases. Herbal medications have the potential to be an effective treatment for liver problems. An extensive review of the literature on hepatoprotective plants clearly shows that herbal medications have significant promise for the treatment of liver ailments. It is difficult to find effective treatments for common liver conditions such as cirrhosis, fatty liver, and chronic hepatitis. There aren't many therapeutic drugs that work well and rarely cause side effects. Few plants can effectively treat liver disorders, so there is a lot of interest in researching the many plant therapies that can help with liver diseases. As a result, we conclude that herbs are an important source of hepatoprotective and liver regeneration drugs. More study is needed, however, to identify, characterize, and standardize the active substances, beneficial compounds, and formulations for the treatment of liver illnesses. The availability of modern hepatoprotective medications with realistic clinical utility is still quite restricted, and the discovery of new compounds with similar potentials will undoubtedly encourage the drug discovery process. Keywords: Herbal Medicine, Hepatotoxicity, Hepatoprotective, Antioxidant Activities

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“…But, in this study the dose they have used is too high and it is not successful or rationale for human dose. 71…”

Section: Flacourtia Indicamentioning

confidence: 99%

Roles of Herbals in Paracetamol Induced Hepatotoxicty

Devi,

Verma,

Kumar

2023

J. Drug Delivery Ther.

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“…Both phytochemical and pharmacological studies have revealed that extracts from different parts and the main active components of F. jangomas demonstrate antimicrobial, antidiabetic, antidiarrheal, and antioxidant properties [20,21]. Moreover, a recent study noted the hepatoprotective activity of F. jangomas in the Paracetamol-induced HepG2 cell line [22].Hence, the objective of this research is to identify a highly selective compound that targets both the androgen receptor and/oracetyl cholinesterase, with the potential to serve as a therapeutic agent for the treatment of liver-related diseases.…”

Section: Introductionmentioning

confidence: 99%

In Silico Evaluation Of Flacourtia Jangomas Compounds For Hepatoprotective Activity: A Molecular Docking Study

Barbhuiya,

Choudhury,

Laskar

et al. 2024

jaz

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The liver is prone to damage induced by xenobiotics, which significantly contributes to the widespread prevalence of liver diseases. To explore potential therapeutic avenues, this in silico study utilizes molecular docking techniques to elucidate interactions between bioactive compounds derived from Flacourtia jangomas and their target proteins, particularly the androgen receptor (AR) and acetyl cholinesterase, both implicated in hepatocellular carcinogenesis. While pharmaceutical drugs for liver diseases exist, their limitations necessitate the exploration of alternative options. Plant-derived compounds have garnered attention for their potential beneficial effects, with Flacourtia jangomas emerging as a promising candidate due to its known pharmacological activities. Through our investigation, we identified several compounds, including catechin, limonin, jangomolide, rutin hydrate, hydnocarpic acid, and chaulmoogric acid, which exhibited notable interactions with AR and acetyl cholinesterase. Enzalutamide, an AR inhibitor, demonstrated a docking score lower than catechin but higher than other compounds, indicating its potential therapeutic efficacy. Catechin exhibited the highest binding affinity, supported by more favorable scores, signifying strong interactions with AR. Rutin hydrate displayed superior docking parameters against acetyl cholinesterase compared to neostigmine. Considering various scoring parameters such as lipo, ambig, clash, and rot scores, catechin and rutin hydrate emerged as favorable options over enzalutamide and neostigmine, respectively. However, experimental validation is essential to confirm these findings. The compounds identified in this study hold promise for the development of clinically effective hepatoprotective agents.

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Hepatoprotective activity of Flacourtia jangomas (Lour.) Raeuschleaves and fruit methanolic extract on paracetamol-induced hepatotoxicity in HepG2 Cells

Cited by 2 publications

References 7 publications

Roles of Herbals in Paracetamol Induced Hepatotoxicty

Roles of Herbals in Paracetamol Induced Hepatotoxicty

In Silico Evaluation Of Flacourtia Jangomas Compounds For Hepatoprotective Activity: A Molecular Docking Study

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