Hepatoprotective activity of<i>Chenopodium album</i>Linn. in Ethanol induced Hepatotoxicity in Rats

Karwani, Gauri; Sisodia, Siddhraj S.

doi:10.5958/0974-360x.2015.00105.5

Cited by 8 publications

(6 citation statements)

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“…T.erecta treatment displayed marked reduction in the levels of cardiac markers as compared to the DOX intoxicated rats which is incorporated with the previous reports 16 . The major mechanism in DOX mediated ROS production is via enzymatic conversion of DOX quinine moiety to semiquin one radical by NADH dehydrogenase and cytochrome P450 reductase 17 .…”

Section: Discussionsupporting

confidence: 76%

“…Estimation of cardiac markers 16 The creatinine kinase-MB (CK-MB) and lactate dehydrogenase (LDH) in serum were estimated using commercial biochemical kits from Pathozyme, India. Further the serum cardiac troponin (cTn) cTn-I was estimated by ELISA method using the kits obtained from Life Technologies (India) Pvt.…”

Section: 7mentioning

confidence: 99%

“…Measurement of Lipid peroxidation and protein carbonyl content 16 The lipid peroxidation (LPO) marker, malondialdehyde (MDA) and protein carbonyl content (PCC) was measured according to the instructions provided in the kit obtained from Span Diagnostics Ltd, Gujarat, India…”

Section: 8mentioning

confidence: 99%

“…Measurement of antioxidants 16 The cardiac level of antioxidants catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione (GSH) were estimated according to the instructions provided in the kit obtained from Span Diagnostics Ltd, Gujarat, India.…”

Section: 9mentioning

confidence: 99%

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Cardio protective efficacy of Tagetes Erecta Methanolic extract in doxorubicin induced oxidative cardiac damage.

AithamrajuSatish

Shanmuga

2022

Int J Life Sci Pharm Res

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Doxorubicin (DOX) is a highly prevalent chemotherapy agent used in the management of a wide range of cancer. However, on prolonged clinical use, DOX causes cardio toxicity and it was restricted in the clinical regimen. Tagetes erecta or marigold is a potent medical plant with many biological actions and it contains chief carotenoid known as lutein. So we have evaluated the efficacy of methanolic extract of Tagetes erecta (METE) against DOX induced cardio toxicity. Animals were randomly divided into five groups, such as control group treated with vehicle, DOX group administered with DOX 15 mg/kg, i.p, extract treated group with METE 200 and 400 mg /kg orally and Digoxin standard group for 14 days. After the experimental period, various biochemical markers were analyzed for the assessment of DOX mediated cardio toxicity. DOX intoxicated rats showed significant (p<0.05) increase in serum cardiac markers (creatine kinase, lactate dehydrogenase and Cardiac troponin-I) , lipid peroxidation and protein carbonyl content and reduced antioxidants (SOD, CAT, Gpx and GSH) level in heart tissue. Treatment with METE (200 and 400mg/kg, p.o.) restored the altered biochemical level to normalcy. Thus, the results of the study suggest that Tagetes erecta showed promising cardio protective activity in DOX induced cardiac damage mediated by its membrane stabilizing and antioxidant effect.

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Section: Discussionsupporting

confidence: 76%

Section: 7mentioning

confidence: 99%

Section: 8mentioning

confidence: 99%

Section: 9mentioning

confidence: 99%

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Cardio protective efficacy of Tagetes Erecta Methanolic extract in doxorubicin induced oxidative cardiac damage.

AithamrajuSatish

Shanmuga

2022

Int J Life Sci Pharm Res

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“…Marigold flowers are characterized by yellow or orange color with flowers that are fat, slightly rounded, and have overlapping petals 7 . This flower has activity as an antioxidant, antibacterial, and hepatoprotective activity due to the content of bioactive compounds in this flower, such as alkaloids, essential oils and flavonoids, terpenoids, alkaloids, and saponins 8,9 .…”

Section: Buteterfly Pea Flowers (Clitoria Ternatea L)mentioning

confidence: 99%

Familiar Edible Flowers in Indonesia

Kresnapati¹,

Ramandha²,

Indriani³

2022

Pharmaceutical and Clinical Journal of Nusantara

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Flowers besides being used as ornamental plants, they can also be consumed. Flowers that can be consumed are called Edible Flowers. Edible flowers in general can be consumed directly, usually in tea or can be served in the form of processed food. Edible flowers contain phytochemical compounds such as anthocyanins, flavonoids, phenolics, carotenoids which are useful as antioxidants. Indonesia is rich in biodiversity with a variety of plant species that can grow, including edible flowers. There is diversity, but only a few edibles that can grow and are familiar to Indonesian people will be reviewed in this article.

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Effect of saffron (stigma of Crocus sativus L.) aqueous extract on ethanol toxicity in rats: A biochemical, histopathological and molecular study

Rezaee-Khorasany

Razavi

Taghiabadi

et al. 2019

Journal of Ethnopharmacology

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Hepatoprotective activity ofChenopodium albumLinn. in Ethanol induced Hepatotoxicity in Rats

Cited by 8 publications

References 0 publications

Cardio protective efficacy of Tagetes Erecta Methanolic extract in doxorubicin induced oxidative cardiac damage.

Cardio protective efficacy of Tagetes Erecta Methanolic extract in doxorubicin induced oxidative cardiac damage.

Familiar Edible Flowers in Indonesia

Effect of saffron (stigma of Crocus sativus L.) aqueous extract on ethanol toxicity in rats: A biochemical, histopathological and molecular study

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