Hepatoprotective activity of Picrorhiza kurroa and Berberis lycium is mediated by inhibition of COX-2 and TGF-β expression in lantadenes-induced sub-chronic toxicity in guinea pigs

Medicinal herbs and their metabolites with biological potential to protect and combat liver toxicity and its disorders: A review

“…Some plants that possess hepatoprotective activity due to their active glycosides, such as amburoside A, caffeoyl-glucoside, kinsenoside, saikosaponins, kaempferol-3-O-rutinoside,ononitol monohydrate, picroside, kutkoside and brasoside. Picroside II, present in Picrorhiza kurroa (Scrophulariaceae), protects against cholestasis possibly via activating the FXR, which controls the transporters and enzymes involved in maintaining the balance of bile acids [ 179 , 245 ].…”

“…Also nephroprotective, antiasthmatic and anticancerous. [ 179 ] Piper chaba (Piperaceae) Aqueous-acetone extract of Fruit Rat Paracetamol and d -galacto-samine 200 mg/kg b.w. SGPT↓, SGOT↓, ALP↓, Total protein↑ Used in dyspepsia, colic and gastralgia, asthma, bronchitis, fever, inflammation, piles, pain in abdomen and anus.…”

Pharmacological and Clinical Efficacy of Picrorhiza kurroa and Its Secondary Metabolites: A Comprehensive Review

“…Another study was conducted to investigate whether freeze-dried methanolic extracts of Berberis lycium root bark and P. kurroa rhizomes provided any degree of hepatoprotection against lantadenes-induced sub-chronic hepatopathy in guinea pigs animal models. A 200 mg/kg body weight dose of B. lycium and P. kurroa extracts reduced the hepatotoxicity caused by subchronic exposure to lantadenes [ 150 ].…”

“…Therefore, it can be concluded that picroliv has therapeutic effectiveness against E. histolytica and stimulates hepatic damage [ 154 ]. Moreover, P. kurroa extract showed promising benefits against lantadenes-induced hepatotoxicity and significantly reverted these abnormalities to a state close to normal [ 150 ]. A herbal preparation known as Enliv containing P. kurroa elevated lipid peroxidation levels in liver tissues and reduced the level of glutathione induced by paracetamol [ 155 ].…”

“…The P. kurroa extract at 200 mg/kg produced favorable effects against lantadenes-induced hepatic toxicity and significantly reversed these changes to near normal. The hepatotoxicity brought on by sub-chronic exposure to lantadenes may be reduced by P. kurroa extract at a dose of 200 mg/kg [ 150 ]. P. kurroa is abortifacient and should be contraindicated during pregnancy [ 45 ].…”