Hepatoprotective activity of quercetin against acrylonitrile‐induced hepatotoxicity in rats

Abstract

Acrylonitrile is a potent hepatotoxic, mutagen, and carcinogen. A role for free radical-mediated lipid peroxidation in the toxicity of acrylonitrile has been suggested. The present study was designed to assess the hepatoprotective effect of quercetin against acrylonitrile-induced hepatotoxicity in rats. Liver damage was induced by oral administration of acrylonitrile (50 mg/kg/day/5 weeks). Acrylonitrile produced a significant elevation of malondialdehyde (138.9%) with a marked decrease in reduced glutathione (72.4%), and enzymatic antioxidants; superoxide dismutase (81%), and glutathione peroxidase (53.2%) in the liver. Serum aspartate aminotransferase, alanine aminotransferases, direct bilirubin, and total bilirubin showed a significant increase in acrylonitrile alone treated rats (115.5%, 110.8%, 1006.8%, and 1000.8%, respectively). Pretreatment with quercetin (70 mg/kg/day/6 weeks) and its coadministration with acrylonitrile prevented acrylonitrile-induced alterations in hepatic lipid peroxides and enzymatic antioxidants as well as serum aminotransferases and bilirubin. Histopathological findings supported the biochemical results. We suggest that querectin possess hepatoprotective effect against acrylonitrile-induced hepatotoxicity through its antioxidant activity.

Chitosan nanoparticles and quercetin modulate gene expression and prevent the genotoxicity of aflatoxin B 1 in rat liver

“…The hepatoprotective effect of Q was also investigated by Padma et al [105] who concluded a protective effect against oxidative damage due to its free radical scavenging action and antioxidant nature. In the same respect, Abo-Salem et al [106] showed that treatment with Q decreased the elevation in biochemical parameters induced by acrylonitrile and it was effective in structural improvement of liver. Another study demonstrated that administration of Q prior to sodium fluoride intoxication prevents hepatotoxicity and oxidative stress in rat liver, probably due to its antioxidant effect [107] .…”

Possible Synergistic Effect and Antioxidant Properties of Chitosan Nanoparticles and Quercetin against Carbon Tetrachloride-Induce Hepatotoxicity in Rats

“…Padma et al [103] investigated the protective effect of quercetin against lindane-induced hepatotoxicity and suggested that the protective effect of quercetin on oxidative damage was attributable to its free radical scavenging action and antioxidant nature. Furthermore, Abo-Salem et al [104] showed that treatment with quercetin decreased the acrylonitrile-induced elevation in biochemical parameters and was effective in structural improvement of liver. Moreover, Nabavi et al [105] showed that the administration of quercetin prior to sodium fluoride intoxication prevents hepatotoxicity and oxidative stress in rat liver, probably because of its antioxidant effect.…”

Effects of acrylonitrile on the pathological morphology and apoptosis of neurons in rats

“…Effects of acrylonitrile on neurons 2007; Abo- Salem et al, 2011). Apoptosis is a cell suicide mechanism that enables metazoans to control cell number and eliminate cells that threaten the animal's survival (Watcharasit et al, 2010;Weyhenmeyer et al, 2012).…”

“…ACN was classified as a possible human carcinogen (Group 2B) by the International Agency for Research on Cancer in 1999. Although the pathogenetic mechanism of the carcinogenesis is still unclear, an imbalance of apoptosis has been confirmed to be involved, and this has become a recent topic of research interest (Krantic et al, 2007;Watcharasit et al, 2010;Abo-Salem et al, 2011). Many studies have investigated biological markers, such as Ki-67, p53, Bcl-2, and Cox-2, that can be used to classify carcinoma, atypical hyperplasia, and/or benign hyperplasia (Apostolou et al, 2013).…”