Hepatoprotective activity of Somanathi Tamra Bhasma in paracetamol induced liver toxicity in albino- rats

Honwad, Sudheendra; Bairy, T Shridhara; Ravi, M; Ravishankar, B

doi:10.31254/phyto.2015.4303

Cited by 2 publications

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“…The incidence of drug-induced liver injury varies across populations and depends on factors such as age, gender, genetic predisposition, and concomitant drug use. [5] Given the significance of this issue, there is a pressing need for effective hepatoprotective agents that can mitigate the adverse effects of anti-tubercular drugs on the liver. Several natural products, including herbal extracts and minerals, have been investigated for their hepatoprotective potential.…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective Assessment of Copper Calx against Anti-Tubercular Drug-induced Hepatotoxicity in Rats

Sharique,

Hariprasad MG,

Moqbel Redhwan

et al. 2023

Pharmacogn. Res.

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Background: Anti-Tubercular Drugs (ATDs), while effective in treating tuberculosis, are associated with hepatotoxicity, leading to liver damage and complications. Calx of Copper, a traditional Ayurvedic preparation, has shown potential hepatoprotective properties. Objectives: To investigate the potential hepatoprotective role of Calx of Copper in mitigating ATD-induced hepatotoxicity and to examine its impact on liver function markers and histopathological changes in rats. Materials and Methods: Thirty male Wistar rats were randomly divided into five groups (n=6 per group): control, ATD, Calx of Copper, ATD+Calx of Copper, and silymarin (used as a standard hepatoprotective agent). Hepatotoxicity was induced in the ATD, ATD+Calx of Copper, and silymarin groups by administering a combination of isoniazid, rifampicin, and pyrazinamide for 25 days. Calx of Copper and silymarin were orally administered at doses of 6.17 mg/kg and 12.33 mg/kg, and 300 mg/kg b.w, respectively, in their respective groups. Liver function markers, including serum transaminase and alanine Aminotransferase (ALT), were measured at the end of the study. A histopathological examination of liver tissues was also performed. Results: ATDinduced hepatotoxicity was evident through elevated serum SGPT, SGOT, ALT, and ALP levels and histopathological alterations in liver tissue. Co-administration of Calx of Copper significantly reduced SGPT, SGOT, ALT, and ALP (p<0.05) and improved liver histopathological changes compared to the ATD group. The hepatoprotective effect of Calx of Copper was comparable to that of silymarin. Conclusion: Copper calx demonstrated significant hepatoprotective activity against ATD-induced hepatotoxicity in rats, as evidenced by normalizing liver function markers and histopathological improvements. These findings suggest that Calx of Copper may be a promising adjuvant therapy for mitigating liver damage associated with anti-tubercular drug treatment.

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Section: Introductionmentioning

confidence: 99%