Hepatoprotective activity of total iridoid glycosides isolated from Paederia scandens (lour.) Merr. var. tomentosa

Peng, Wei; Qiu, Xiao-Qian; Shu, Zhiheng; Liu, Qingchun; Hu, Mei-Bian; Han, Ting; Rahman, Khalid; Qin, Lu-Ping; Zheng, Cheng‐Jian

doi:10.1016/j.jep.2015.08.032

Cited by 47 publications

(30 citation statements)

References 20 publications

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“…Previous reports demonstrated that traditional Chinese medicines (TCM) are important resources for discovery of useful potential drugs with low side-effects, for treating various diseases. Currently, many studies have consistently demonstrated that TCMs are especially suitable agents for protection of liver function and treatment of liver diseases [9,10].…”

Section: Discussionmentioning

confidence: 99%

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Hepatoprotective effect of Fufang-Huanglu oral liquid on α- naphthylisothiocyanate-induced hepatitis jaundice in mice

Zhen-zhen¹,

Li²,

Zhang³

et al. 2017

Trop. J. Pharm Res

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Section: Discussionmentioning

confidence: 99%

“…The results of the present study revealed that HOL caused significant decreases in TNF-α levels. MDA, the major end products of lipid peroxidation, is considered a marker of oxidative stress and one of the indicators of liver injury [9,18]. In addition, SOD is an antioxidant enzyme recognized as an inhibitor of oxidative stress [19,20].…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective effect of Fufang-Huanglu oral liquid on α- naphthylisothiocyanate-induced hepatitis jaundice in mice

Zhen-zhen¹,

Li²,

Zhang³

et al. 2017

Trop. J. Pharm Res

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“…Pathological slices of rat stomach and duodenum were examined under an Olympus microscope (Olympus, Tokyo, Japan) after H&E staining to determine morphological features [7].…”

Section: Histopathological Examinationmentioning

confidence: 99%

Comparative studies on the regulatory effects of raw and charred hawthorn on functional dyspepsia and intestinal flora

Wei¹,

Ai²,

Chen³

et al. 2019

Trop. J. Pharm Res

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Purpose: To compare the effects of raw hawthorn (RH) and charred hawthorn (CH) on functional dyspepsia (FD) and intestinal flora (IF). Methods: A rat model of FD was established through use of a chronic stimulator. Rat models were evaluated by the rat's physical state, body weight, diet, and histopathological examination. After RH or CH administration, the digestive function of the rats was evaluated by determining gastric emptying and intestinal propulsion rate, diversity of intestinal flora. Results: RH and CH both improved gastric emptying and intestinal propulsion rate in FD group when compared to control group (p < 0.05). CH yielded higher treatment effectiveness than RH. Sixteen phyla of microbiomes were recognized from all samples. After FD model establishment, the relative abundance of Lactobacillus, Lachnospiraceae and Bacteroidales decreased compared to normal control rats. On the other hand, the relative abundance of Helicobacter and Bacteroides in the model control group increased compared to normal control. After RH and CH treatment, the relative abundance of all dysregulated phyla was restored to varying degrees, but the levels after CH treatment were similar to those of the normal control group. Conclusion: The relative abundance of intestinal flora of FD model rats is significantly different from that of rats in normal control group. Thus, RH and CH intervention improves digestive function, and the mechanisms may be related to adjustment of gut dysbacteriosis.

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“…In previous studies, natural resources for the treatment of hepatocellular carcinoma have been found in the members of Rubiaceae family, such as Oldenlandia diffusa [ 15 ] and Paederia scandens [ 16 ]. The phytochemical studies of N. reticulate have not yet been performed.…”

Section: Introductionmentioning

confidence: 99%

Three New Iridoid Derivatives Have Been Isolated from the Stems of Neonauclea reticulata (Havil.) Merr. with Cytotoxic Activity on Hepatocellular Carcinoma Cells

et al. 2018

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Three new iridoids, namely neonanin A (1), neonanin B (2) and neoretinin A (3), as well as twelve known compounds, 6-hydroxy-7-methyl-1-oxo-4-carbomethoxyoctahydrocyclopenta[c]pyran (4), 4-epi-alyxialactone (5), loganetin (6), loganin (7), phenylcoumaran-α′-aldehyde (8), cleomiscosin A (9), ficusal (10), balanophonin (11), vanillic acid (12), p-coumaric acid (13), cis,trans-abscisic acid (14), and trans,trans-abscisic acid (15) were isolated from the stems of Neonauclea reticulata (Havil.) Merr. These new structures were determined by the detailed analysis of spectroscopic data and comparison with the data of known analogues. Compounds 1–13 were evaluated using an in-vitro MTT cytotoxic assay for hepatocellular carcinoma (HCC) cells, and the preliminary results showed that ficusal (10), balanophonin (11), and p-coumaric acid (13) exhibited moderate cytotoxic activity, with EC50 values of 85.36 ± 4.36, 92.63 ± 1.41, and 29.18 ± 3.48 µg/mL against Hep3B cells, respectively.

show abstract

Hepatoprotective activity of total iridoid glycosides isolated from Paederia scandens (lour.) Merr. var. tomentosa

Cited by 47 publications

References 20 publications

Hepatoprotective effect of Fufang-Huanglu oral liquid on α- naphthylisothiocyanate-induced hepatitis jaundice in mice

Hepatoprotective effect of Fufang-Huanglu oral liquid on α- naphthylisothiocyanate-induced hepatitis jaundice in mice

Comparative studies on the regulatory effects of raw and charred hawthorn on functional dyspepsia and intestinal flora

Three New Iridoid Derivatives Have Been Isolated from the Stems of Neonauclea reticulata (Havil.) Merr. with Cytotoxic Activity on Hepatocellular Carcinoma Cells

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