Hepatoprotective activity of Uvaria chamae root bark methanol extract against acetaminophen-induced liver lesions in rats

Madubunyi, Ifeanyi Innocent

doi:10.1007/s00580-010-1072-8

Cited by 6 publications

(2 citation statements)

References 20 publications

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“…The acetaminophen-induced elevation of the LPO in rats was significantly ( P <0.05) decreased in the presence of Uvaria chamae root bark methanol extract. [32] Therefore, our results suggest that the agents in the extract may be acting by preventing the T+MNU-induced LPO.…”

Section: Discussionmentioning

confidence: 82%

Modulatory effects of Crataeva nurvala bark against testosterone and N-methyl-N-nitrosourea-induced oxidative damage in prostate of male albino rats

Kumar¹,

Deepa²,

Rathi³

et al. 2012

Phcog Mag

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Background:Antioxidant properties of Crataeva nurvala bark contains a variety of the bioactive phytochemical constituents in medicinal plants which include flavonoids, phenolic compounds, tannins, anthracene derivatives, and essential oils. Components from Crataeva nurvala bark have been accounted to play an important role in scavenging free radicals generated by mutagens and carcinogens. Androgens are the key factors in either the initiation or progression of prostate cancer by inducing oxidative stress. In the present set of investigations, the antioxidative potential of Crataeva nurvala bark extract against androgen-mediated oxidative stress in male Wistar rats has been studied.Materials and Methods:Oxidative damage in prostate was induced in rats by the injection of testosterone (100 mg/kg body weight [bw]) for 3 days followed by injection of chemical carcinogen N-Methyl N-Nitroso Urea (50 mg/kg bw) for 1 week. The oxidative damage in prostate-induced rats were treated with the ethanolic extract of Crataeva nurvala bark (150 mg/kg bw) and testosterone injection (2 mg/ kg bw) was also continued through the experimental period of 4 months. The prostate tissue was dissected out for biochemical analysis of lipid peroxidation and enzymic-antioxidants viz. catalase, superoxide dismutase, glutathione peroxidase, glutathione-S-transferase, and glutathione reductase; the non-enzymic antioxidants viz. reduced glutathione, and Vitamin C.Results:The results revealed that testosterone administration induced the oxidative stress in rat prostate; however, in drug (150 mg/kg bw) supplemented groups, a significant protective effect of Crataeva nurvala bark against testosterone-induced oxidative injury was recorded.Conclusion:Hence, the study reveals that constituents present in Crataeva nurvala bark impart protection against androgen-induced oxidative injury in prostate.

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Section: Discussionmentioning

confidence: 82%

Modulatory effects of Crataeva nurvala bark against testosterone and N-methyl-N-nitrosourea-induced oxidative damage in prostate of male albino rats

Kumar¹,

Deepa²,

Rathi³

et al. 2012

Phcog Mag

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“…The AA-induced elevation of the lipid peroxidation in rats was significantly (p < 0.05) decreased in the presence of U. chamae root bark methanol extract. A protection of 56% against the tert-butyl hydroperoxideinduced lipid peroxidation in rats was obtained by pretreatment with the methanol extract (Madubunyi, 2012). Liver-protective medicinal plants contain a variety of chemical compounds, such as phenols, coumarins, lignans, essential oils, monoterpenes, glycosides, alkaloids, carotenoids, flavonoids, organic acids and xanthines (Bhauna and Kumar, 2009) which is evident in the study above.…”

Section: Hepatoprotective Activitymentioning

confidence: 97%

A review: secondary metabolites of Uvaria chamae p. Beauv. (Annonaceae) and their biological activities

Abu

Rex-Ogbuku

Idibiye

2018

International Journal of Agriculture Environment and Food Sciences

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The primary metabolites are of major importance to plants, while the secondary metabolites are of medicinal value to man (Trease and Evans, 1989) and these can equally be obtained from various anatomical structures of plants (Fahn, 1974). Man has benefited from the presence of these chemicals by exploiting the plant products as sources of sustenance in a variety of ways. For example, many drugs today are of plant origin. Pharmacological history is abounding with examples such as quinine, aspirin, picrotoxin, reserpine etc., while many of the synthetic drugs are fashioned after natural plant products (Sofowora, 1982). The Annonaceae is a large family of shrubby aromatic plants composed of 112 genera with about 2,150 species (Mabberly, 1997) and grows to about 3.6 m to 4.5 m tall. Uvaria chamae P. Beauv., commonly known as "finger root" is a climbing shrub and is found in the tropical wet and dry forests of west and central Africa along coastal scrubland. It is found alongside water in marsh forest with Alchornea cordifolia, Thalia (Maranthaceae), Dracaena arborea, Cyrtosperma, Anthocleista vogeliana, ferns, Mussa endaiserteana, Mitragyna stipulosa, Cyclosaurus (Arbonnier, 2004; Bongers et al., 2005). The fruit carpel's are in finger-like clusters, the shape giving rise to many vernacular names translated as "bush banana" or the like implying wildness where in Igala is called Ayiloko, Hausa: Kaskaifi, Yoruba: Okooja and Ghana: Akotompo. The fruits are yellow when ripe and have a sweet pulp which are edible and widely eaten (Iwu, 1993). Uvaria chamae is an important medicinal plant. The secondary metabolites isolated from the plant and their biological activities are reviewed. Chemical Constituents The search for the concerned active compounds has led to isolation of the several flavonoids, alkaloids, annonaceous acetogenins and essential oils from different plant parts of U. chamae. The preliminary phytochemicals detected from different parts of the plant are listed in Table 1 which shows the phytochemical groups present or absent in different plant parts. The bioactive compounds present in the essential oils and flavonoids isolated from the plant are listed in Table 2 and 3. Essential oils The essential oil from the root bark and leaves of U. chamae showed the presence of different constituents (Table 2). The oil from the root contained a number of oxygenated benzylbenzoate derivatives and ethers. The oil from the leaf contains predominantly sesquiterpene hydrocarbons, oxygenated sesquiterpenes, monoterpene hydrocarbons as well as oxygenated ones (Ayedoun et al., 1999). Thymoquinoldimethyl ether, benzyl benzoate, chamanen, omethoxybenzylbenzoate, o-methoxybenzyl benzyl ether, and di-o-methoxybenxyl ether are the major components of the root oil (Park and Sutherland, 1969; Lasswell and Hufford, 1977a) while the oil from the leaf was dominated by 1-nitro-2-phenylethane (63.2%), linalool (9.9%), and germacrene D (6.6%) (Moses et al., 2013) as shown in Table 2. The bioactivities of the major constituents account for t...

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Uvaria chamae

Lim¹

2011

Edible Medicinal and Non-Medicinal Plants

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Hepatoprotective activity of Uvaria chamae root bark methanol extract against acetaminophen-induced liver lesions in rats

Cited by 6 publications

References 20 publications

Modulatory effects of Crataeva nurvala bark against testosterone and N-methyl-N-nitrosourea-induced oxidative damage in prostate of male albino rats

Modulatory effects of Crataeva nurvala bark against testosterone and N-methyl-N-nitrosourea-induced oxidative damage in prostate of male albino rats

A review: secondary metabolites of Uvaria chamae p. Beauv. (Annonaceae) and their biological activities

Uvaria chamae

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