Hepatoprotective and anti-inflammatory effects of new lectin purified from Morus nigra against lipopolysaccharideinduced oxidative stress in rats

Bahi, Ahlem; Necib, Youcef

doi:10.22376/ijpbs.2018.9.1.p66-72

Cited by 4 publications

(4 citation statements)

References 20 publications

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“…[33][34][35][36][37][38][39][40][41][42][44][45][46]65 anti-viral, anti-inflammatory, anti-tumor, neuroprotective, anti-asthmatic, anti-oxidant, hepatoprotective, immunomodulator, anti-platelet, analgesic, bioavailability enhancer, cardioprotective , neuroprotective, antibacterial Cyperus rotundus Linn. [47][48][49][50][51][52][53][55][56][57][58][59] anti-oxidant, anti-ulcer, analgesic, anti-microbial, cytotoxic, anti-convulsant, anti-diabetic, anti-diarrheal, antispasmodic, anti-inflammatory, hepatoprotective, cardioprotective, anti-lipidemic, anti-platelet, antidepressant, neuroprotective In albino-wistar rats, the acute toxicity experiment showed that the drug did not produce any signs and symptoms of toxicity (or mortality) up to the dose of 2000 mg/kg 2.…”

Section: Medicinal Plantmentioning

confidence: 99%

Balchaturbhadra Churna as a potential medicine for SARS-CoV2 infection in pediatric setting

Choudhary,

Thrigulla,

Gundeti

et al. 2022

AYU (An International Quarterly Journal of Research in Ayurveda)

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Background: Balchaturbharda Churna (BC), is four ingredients (Aconitum heterophyllum Wall. Ex Royle, Pistacia integerrima stew. Ex brandis, Piper Longum Linn. and Cyperus rotundus linn.) Ayurvedic powder dosage form, which is commonly prescribed for treating fever, cough, diarrhea in pediatric setting. Objective: This present study evaluates the possible effect of phytochemicals from the ingredients of BC on SARS-CoV-2 main protease (M Pro ), RNA dependent RNA polymerase (RdRP) and spike-ACE2 (SA) complex through in silico evaluation. Materials and methods: X-ray crystal structure of M Pro and SA complex with PDB IDs 6LU7 and 6LZG and the SWISS model of RdRP were used as the drug targets. An enhanced docking methodology has been implemented to perform the molecular docking of these phytochemicals against the above-mentioned drug targets of SARS-CoV-2. DOCK 6 was used to perform docking of these phytochemicals. The ADMET and drug likeliness properties for these selected phytochemicals was performed using SWISS ADME. Results:The ensemble docking studies suggest that aconitine, lappaaconitine from Aconitum heterophyllum, 2'-hydroxyisorientin from Pistacia intergerrima and guineesine, pipercide and piperoic acid from Piper longum hold the potential to bind favorably with the SARS-CoV-2 drug targets. The drug likeliness and ADMET properties were calculated for these phytochemicals indicate that all the three phytochemicals from Piper longum were observed to have considerate drug-likeliness and ADMET properties. Aconitine has molecular weight slightly higher than 500 kDA and has more than 10 hydrogen bond acceptors. Conclusion:The in-silico study demonstrates that phytochmeicals from the ingredients BC viz., aconitine, lappaaconitine from Aconitum heterophyllum, 2'-hydroxyisorientin from Pistacia intergerrima and guineesine, pipercide and piperoic acid from Piper longum hold the potential to bind favourably with the SARS-CoV-2 drug targets. The study also provides evidence for drug likeliness and ADMET properties for these phytochemicals suggesting that BC can be further studied as potential drug of choice for treating SARS-CoV-2infection in paediatric cases.

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Section: Medicinal Plantmentioning

confidence: 99%

Balchaturbhadra Churna as a potential medicine for SARS-CoV2 infection in pediatric setting

Choudhary,

Thrigulla,

Gundeti

et al. 2022

AYU (An International Quarterly Journal of Research in Ayurveda)

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“…These substances are considered antioxidants, and they are also a sedative and antipyretic substance, as they work to reduce the temperature of birds during the transport process by dissipating heat and reducing the speed of panting, thus reducing loss. Fluids reduce dehydration of the birds, and this in turn reduces weight loss during the transfer process [22]; [23]; [24]; [25]; [9] on the one hand, and on the other hand, these factors work Spraying calms and anesthetizes the birds during the transport process, and thus reduces the physical and psychological stress in the birds, which works to secrete adrenal cortex hormones and secrete corticosterone, which works to break down proteins and manufacture glucose from non-carbohydrate sources [26].…”

Section: Discussionmentioning

confidence: 99%

Effect of spraying with the extract of the local anemone coronaria flowers and isoflurane in reducing the economic losses caused by stress of transporting broiler

Tamimi¹,

Shanoun²,

Mohammed³

2023

kujas

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The effect of the extract on the transport stress of broiler chickens transported during different seasons of the year was experimentally studied. During the months of February, March, July, August, and different regions of Iraq, with a density of 10 or 12 birds per cage, as the Ross 308 birds were divided into 10 treatments per move and three replicates for each treatment. The T1 treatment was control without spraying, and the number of birds was 10 in the cage. T2 control without spraying and the number of birds 12 in the cage. T3 Spraying the birds with an extract of local Anemone coronaria flowers at a concentration of 2% and the number of birds is 10 in the cage. T4 Spraying the birds with an extract of local Anemone coronaria flowers at a concentration of 4% and the number of birds 10 in the cage. T5 Spraying the birds with an extract of local Anemone coronaria flowers at a concentration of 6% and the number of birds 10 in the cage. T6 Spraying the birds with an extract of local Anemone coronaria flowers at a concentration of 2%. The number of birds is 12 in the cage. T7 Spraying the birds with an extract of local Anemone coronaria flowers at a concentration of 4%. The number of birds is 12 in the cage. T8 Spraying the birds with an extract of local Anemone coronaria flowers at a concentration of 6% and the number of birds is 12 in the cage. T9 Spraying birds with isoflurane at a concentration of 6%, the number of birds is 10 per cage. T10 Spraying birds with isoflurane at a concentration of 6%. The number of birds is 12 per cage ,The birds were sprayed for 5 minutes before the transfer process, according to the above treatments, and the duration of one transfer was 240 minutes ± 10 minutes, from the results of the field experiment, it can be noted that there was a significant decrease (p < 0.05) in the rate of weight loss during the months of February and March, as the spraying treatments T5, T9, T10 recorded (81, 76, 78) grams, respectively, compared with the treatments T1, T2 (108, 109) grams, respectively, and this was reflected in the percentage of weight loss, as it recorded T5,T9, and T10 (3.01, 2.90, 3.19)% compared to the treatments T1, T2 (4.04, 4.07)%. While T5,T9 and T10 recorded (319.95,300.20, 308.10) Iraqi dinars are the least financial losses for the month of March, but during the summer season, it is noted that the lost weight decreased during the months of July and August in transactions T5,T9and T10 (186,180, 187,) gm, respectively, compared with T1, T2 (216, 220) gm Respectively, it is also noted that the percentage of loss in these transactions decreased, as it recorded T5,T9, T10, (7.71,7.11, 7.36,)%, respectively. It is noted that financial losses decreased in these transactions during the month of August, as it recorded T5, T9 and T10 (734.70, 711.00, 738.65) Iraqi dinars, respectively, compared with T1, T2 (853.200, 869.00) Iraqi dinars, respectively

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“…These findings compare well with the study by Osukoya et al ( 2021 ) that reported that Monodora myristica protein hydrolysates exhibited radical scavenging potential in a concentration-dependent manner based on the protease used and duration of hydrolysis. Several previous studies showed that food-derived protein hydrolysates were capable of scavenging DPPH free radicals such as hydrolysates from Azufrado bean (Bahi et al 2016 ), African breadfruit peptide hydrolysates (Osukoya et al 2020 ), sole fish skin and scale gelatin hydrolysates (Pankyamma et al 2019 ), and protein hydrolysates from grass turtle (Islam et al 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Bioactivities of Garcinia kola enzymatic hydrolysates at different enzyme–substrate ratios

et al. 2023

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Natural products, such as enzymatic hydrolysates and bioactive peptides from dietary sources, are safe alternatives to synthetic compounds linked to various deleterious effects. The purpose of this study is to determine the in vitro bioactivities (antioxidant and anti-inflammatory activities) of Garcinia kola seeds enzymatic hydrolysates (GKPHs) at different enzyme (pepsin)-substrate ratios. G. kola protein, isolated by alkaline solubilization and acid precipitation, was hydrolyzed with pepsin at varying enzyme–substrate (E:S) ratios. The antioxidant parameters investigated include 1,1-diphenyl-2-picrylhydrazyl (DPPH)-radical scavenging, hydrogen peroxide scavenging and ferrous ion (Fe2+) chelating activities. For anti-inflammatory properties, membrane stabilization and protein denaturation activities tests were used. GKPH produced at 1:32 had the highest degree of hydrolysis (66.27 ± 4.21%). All GKPHs had excellent in vitro anti-inflammatory properties. However, only enzymatic hydrolysates produced at 1:16 (E:S) ratio chelated iron (II) and as well had the highest percentage hemolysis inhibition of 84.45 ± 0.007%, percentage protein denaturation inhibition of 53.36 ± 0.01% at maximum concentration and exhibited highest DPPH scavenging activity (87.24 ± 0.10%). The enzymatic hydrolysates had excellent solubility, emulsifying and foaming properties. It could be deduced from this study that pepsin at a ratio of 1:16 of G. kola protein produced the most effective enzymatic hydrolysates in terms of their antioxidant and anti-inflammatory activities. G. kola pepsin enzymatic hydrolysates, thus, have potential in development as functional foods and as therapeutics pharmaceutical industries in the management of diseases associated with oxidative stress and inflammation owing to their excellent functional, antioxidant and anti-inflammatory properties.

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Hepatoprotective and anti-inflammatory effects of new lectin purified from Morus nigra against lipopolysaccharideinduced oxidative stress in rats

Cited by 4 publications

References 20 publications

Balchaturbhadra Churna as a potential medicine for SARS-CoV2 infection in pediatric setting

Balchaturbhadra Churna as a potential medicine for SARS-CoV2 infection in pediatric setting

Effect of spraying with the extract of the local anemone coronaria flowers and isoflurane in reducing the economic losses caused by stress of transporting broiler

Bioactivities of Garcinia kola enzymatic hydrolysates at different enzyme–substrate ratios

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