2008
DOI: 10.1016/j.fct.2008.07.010
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Hepatoprotective and antioxidant effects of Commiphora berryi (Arn) Engl bark extract against CCl4-induced oxidative damage in rats

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Cited by 89 publications
(55 citation statements)
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“…It maintains a stable blood glucose level by taking up and storing glucose as glycogen (glycogenesis), breaking it down to glucose when needed (glycogenolysis) and forming glucose from noncarbohydrate sources such as amino acids (gluconeogenesis). The liver also plays an important role in drug elimination and detoxification and liver damage may be caused by many xenobiotics, such as alcohol and many medicines, malnutrition, infection, and anaemia [24,25]. Liver damage is a widespread disease which, in most cases, involves oxidative stress and is characterized by a progressive evolution from steatosis to chronic hepatitis, fibrosis, cirrhosis and hepatocellular carcinoma [26].…”
Section: Liver and Biomarkers Of Hepatoxicitymentioning
confidence: 99%
“…It maintains a stable blood glucose level by taking up and storing glucose as glycogen (glycogenesis), breaking it down to glucose when needed (glycogenolysis) and forming glucose from noncarbohydrate sources such as amino acids (gluconeogenesis). The liver also plays an important role in drug elimination and detoxification and liver damage may be caused by many xenobiotics, such as alcohol and many medicines, malnutrition, infection, and anaemia [24,25]. Liver damage is a widespread disease which, in most cases, involves oxidative stress and is characterized by a progressive evolution from steatosis to chronic hepatitis, fibrosis, cirrhosis and hepatocellular carcinoma [26].…”
Section: Liver and Biomarkers Of Hepatoxicitymentioning
confidence: 99%
“…Consequently, the levels of serum ALT and AST are elevated. SOD and other antioxidant enzymes automatically form a mutually supportive team of defense against ROS (Gowri Shankar et al, 2008). SOD activity being easily inhibited by lipid peroxides or ROS has been suggested (Hsiao et al, 2003).…”
Section: Discussionmentioning
confidence: 99%
“…However, to our knowledge, no published data documenting hepatoprotective effects of RPL are available. Furthermore, previous reports suggest that effective protection against chronic chemical-induced hepatic injury in vivo is usually associated with antioxidant properties (Hsiao et al, 2003;Gowri Shankar et al, 2008;Zeashan et al, 2009). These results motivate us to investigate the potential hepatoprotective and antioxidant activities of RPL extract.…”
Section: Rubus Parvifolius L (Rpl) a Deciduous Thornymentioning
confidence: 99%
“…The CCl 4 induces the peroxidation of lipids that damage the membranes of liver cells and organelles. This results in the release of ALT that is found outside of the mitochondria of the liver into the circulating blood (Shankar et al, 2008) leading to increasing the levels of liver enzymes (ALT). The rising in ALT activity is almost always due to hepatocellular damage (Ravikumar et al, 2005).…”
Section: Mild Chronic Hepatitismentioning
confidence: 99%