Hepatoprotective and neuroprotective activity of liposomal quercetin in combating chronic arsenic induced oxidative damage in liver and brain of rats

Ghosh, Anup K.; Mandal, Ardhendu; Sarkar, Siddik; Das, Nirmalendu

doi:10.3109/10717544.2011.577110

Cited by 46 publications

(26 citation statements)

References 36 publications

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“…Dilating coronary arteries, decreasing blood lipid, antioxidation and anti-inflammation are some of the physiological effects that are attributed to this molecule (Inal & Kahraman, 2000;Comalada et al, 2005;Kandaswami et al, 2005;Li et al, 2009;Ghosh et al, 2011;Landi-Librandi et al, 2012). However, because of its low hydrophilicity, quercetin has minimal absorption in the gastrointestinal tract, and its oral bioavailability is less than 17% in rats and less than 1% in humans (Li et al, 2009;Khaled et al, 2003;Gugler et al, 1975).…”

Section: Introductionmentioning

confidence: 99%

Effect of different stress conditions on the stability of quercetin-loaded lipid microparticles produced with babacu ( Orbignya speciosa ) oil: evaluation of their potential use in food applications

Cazado

Pinho

2016

Food Sci. Technol

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Lipid micro and nanoparticles have been extensively investigated as carriers for hydrophobic bioactives in food systems because they can simultaneously increase the dispersibility of these lipophilic substances and help improve their bioavailability. In this study, lipid microparticles of babacu oil and denatured whey protein isolate were produced, and their ability to protect quercetin against degradation was evaluated over 30 days of storage. Additionally, the lipid microparticles were subjected to the typical stress conditions of food processing (presence of sucrose, salt, and thermal stresses), and their physico-chemical stability was monitored. The data show that the babacu microparticles efficiently avoided the oxidation of quercetin because 85% of the initial amount of the flavonoid was preserved after 30 days. The particles were notably stable up to a temperature of 70 °C for 10 minutes at relatively high concentrations of salt and sucrose. The type of stirring (mechanical or magnetic) also strongly affected the stability of the dispersions.

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Section: Introductionmentioning

confidence: 99%

Effect of different stress conditions on the stability of quercetin-loaded lipid microparticles produced with babacu ( Orbignya speciosa ) oil: evaluation of their potential use in food applications

Cazado

Pinho

2016

Food Sci. Technol

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“…In our study, we found a considerable amount of phenolic and flavonoid content of GK extract that may be the major contributor for the antioxidant role against oxidative stress-induced hepatic damage. NaAsO 2 -induced cytotoxicity is the common method for the measurement of the potential hepatoprotective role of antioxidants [35, 36]. We found cotreatment with the GK increased cell viability and improved the cell morphology.…”

Section: Discussionmentioning

confidence: 65%

In Vivo and In Vitro Hepatoprotective Effects of Geranium koreanum Methanolic Extract via Downregulation of MAPK/Caspase‐3 Pathway

Akanda

Kim

Ahn

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Geranium koreanum (GK) is an indigenous Chinese herbal medicine widely used for the treatment of various inflammation and liver disorders. However, the exact mechanism of action of GK remains unknown. This study aimed to investigate the protective effect and related molecular mechanism of GK on NaAsO2-induced cytotoxicity in HepG2 cells and liver damage in mice. The cytoprotective role of GK was assessed on HepG2 cells using MTT assay. Oxidative stress and lactate dehydrogenase levels were measured with ROS and LDH assay. Histopathology and serum enzymes levels were estimated. The molecular mechanism was evaluated by qPCR and immunoblotting to ensure the hepatoprotective role of GK against NaAsO2 intoxication in mice. We found cotreatment with GK significantly attenuated NaAsO2-induced cell viability loss, intracellular ROS, and LDH release. Hepatic histopathology and serum biochemical parameters, ALT, and AST were notably improved by cotreatment with GK. Beside, GK markedly altered both mRNA and protein expression level of MAPK. The proapoptotic and antiapoptotic protein Bax/Bcl-2 ratio was significantly regulated by GK. Moreover, GK remarkably suppressed the postapoptotic transcription protein cleaved caspase-3 expression. The present study reveals that GK possesses hepatoprotective activity which is probably involved in the modulation of the MAPK/caspase-3 pathway.

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“…However, quercetin is not soluble in water and has poor bioavailability in liver. Nanoparticles can change the transport mechanism of the cell membrane and increase the accumulation of quercetin in the liver to improve its bioavailability [9,13]. As shown in Figure 1B, the nanoparticles were evenly distributed spherical particles.…”

Section: Characteristies Of Nanoliposomal Quercetinmentioning

confidence: 99%

“…Quercetin, a pigment (flavonoid) found in many plants and foods such as wine, apple, onions, green tea, berries and some herbs, has wide bioactivity, 3 including anti-oxidative, anti-fibrotic and anti-inflammatory effects [4,5,6,7]. Its protective effect on liver injury was previously identified [8,9,10,11]. However, quercetin has poor water solubility, so it cannot accumulate well in the liver.…”

Section: Introductionmentioning

confidence: 99%

Protective and Therapeutic Effects of Nanoliposomal Quercetin on Acute Liver Injury in Rats

Liu

Zhang

Liu

et al. 2020

Preprint

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Background Quercetin, a pigment (flavonoid) found in many plants and foods, has good effects on protecting liver function but poor solubility and bioavailability in vivo. A drug delivery system can improve the accumulation and bioavailability of quercetin in liver. Objective In this study, we used liposomal nanoparticles to entrap quercetin and evaluated its protective and therapeutic effects on drug-induced liver injury in rats. Design The nanoliposomal quercetin was prepared by a thin film evaporation-high pressure homogenization method and characterized by morphology, particle size and drug content. Acute liver injury was induced in rats by composite factors, including carbon tetrachloride injection, high-fat corn powder intake and ethanol drinking. After pure quercetin or nanoliposomal quercetin treatment, liver function was evaluated by detecting serum levels of glutamic-pyruvic transaminase (GPT), glutamic-oxal acetic transaminase (GOT) and direct bilirubin (DBIL). Histology of injured liver tissues was evaluated by hematoxylin and eosin staining. Results and discussion On histology, liposomal nanoparticles loading quercetin were evenly distributed spherical particles. The nanoliposomal quercetin showed high bioactivity and bioavailability in rat liver and markedly attenuated the liver index and pathologic changes in injured liver tissue. With nanoliposomal quercetin treatment, the serum levels of GPT, GOT and DBIL were significantly better than treated with pure quercetin. Using liposomal nanoparticles to entrap quercetin might be an effective strategy to reduce hepatic injury and protect hepatocytes against damage. Conclusions Liposomal nanoparticles may improve the solubility and bioavailability of quercetin in liver. Furthermore, nanoliposomal quercetin could effectively protect rats against acute liver injury and may be a new hepatoprotective and therapeutic agent for patients with liver diseases.

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Hepatoprotective and neuroprotective activity of liposomal quercetin in combating chronic arsenic induced oxidative damage in liver and brain of rats

Cited by 46 publications

References 36 publications

Effect of different stress conditions on the stability of quercetin-loaded lipid microparticles produced with babacu ( Orbignya speciosa ) oil: evaluation of their potential use in food applications

Effect of different stress conditions on the stability of quercetin-loaded lipid microparticles produced with babacu ( Orbignya speciosa ) oil: evaluation of their potential use in food applications

In Vivo and In Vitro Hepatoprotective Effects of Geranium koreanum Methanolic Extract via Downregulation of MAPK/Caspase‐3 Pathway

Protective and Therapeutic Effects of Nanoliposomal Quercetin on Acute Liver Injury in Rats

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